“highly significant”

In the 325 mg cohort, plasma salicylate (1061–6299 ng/mL) and salicylurate (673–3355 ng/mL) were detected in 21/21 (100%) subjects ( Figure 4 B), gentisic acid (39–283 ng/mL) was detected in 20/21 (95%) subjects, and salicyl acyl glucuronide (31–396 ng/mL) was detected in 21/21 (100%) subjects ( Figure 4 C) following ASA exposure and were highly significant ( p < 0.0001 for each metabolite, paired t -tests).

NHDF transfected with Smad2 siRNA exhibited a highly significant SMAD2 transcription decrease of 0.1 ± 0.01-fold ( p < 0.0001) compared to negative control siRNA-treated cells, which did not change due to activin A supplementation ( Figure 4 C).

Consistent with this, a highly significant reduction in biofilm formation was observed in the ΔGB mutants compared to the WT parental strains (unpaired t test, P < 0.0001) ( Fig. 4 D ).

Results An increased amount of bone was measured from the crest to the apical portion of the dentate sites on the buccal and lingual sides of both jaws with a highly significant difference detected among all the tested points ( P < 0.0001).

Analyses of tumour characteristics by year of diagnosis showed a significant trend towards lower risk tumours in more recent years, driven by a highly significant trend towards lower nodal status (p<0·0001 for both oestrogen receptor-positive and oestrogen receptor-negative groups; table 1 ; appendix p 35 ).

The difference between left cue and right cue conditions was highly significant (χ 2 = 16.1, p < 0.0001).

Highly significant differences in MICs and MBCs distribution between fluoroquinolones ( p < 0.0001) were observed, and pradofloxacin showed the lowest MICs and MBC ( p < 0.0001) when compared with the other FQs tested. 2.2.

In this group, antibody levels were detected from 14 dpv, showing a highly significant increase ( p < 0.0001) from this timepoint until the end of the study.

Both groups showed highly significant intra-group improvement from preoperative values (paired t-test, p<0.0001).

At 72 h, the inhibition was highly significant for the two differentiation induction media when compared with the control for each cell line (P<0.0001; Fig. 2C ).

On the other hand, assessment of the association between the different pathobiological factors showed a highly significant association of cyclin E with p21 expression ( P <0.0001) and with p53 ( P =0.014).

There was a highly significant difference with MyoG ( p < 0.0001) and Pax7 (p < 0.0001).

When considering only the oil content factor across the three extrusion conditions, a highly significant effect of oil content on glutamate release was observed ( p < 0.0001) (Figure 7 ).

The frequency of IL-21 producing Tfh cells were highly significant ( p < 0.0001) in patients with acute dengue when compared with healthy individuals, where hardly any cytokine production was observed (Fig. 2 d).

The correlation between change in HbA1c and level of HbA1c at start of treatment with HCQ was highly significant (correlation coefficient -0.77, p<0.0001).

In the medial and inferior constrictor muscles, cricopharyngeal muscle, glottic and supraglottic laryngeal areas, arytenoid cartilages, contralateral major salivary glands highly significant dose reductions ( p < 0.0001) of more than 10 Gy were achieved in study treatment plan compared to standard treatment plan.

Geeglm revealed that the negative effect of mother deprivation on the number of successfully reared embryos per spawning was highly significant (anova: df = 1, χ 2 = 387.7, P < 0.0001).

subquinaria revealed a highly significant effect of population type (sympatric versus allopatric; Wald χ 2 = 17.88, p < 0.0001), but no effect of individual population within population type (χ 2 = 1.02, p = 0.91) or trial (χ 2 = 2.12, p = 0.35).

There was a highly significant difference when comparing the animals with light and dark coats in activity “in the shade” and “in the sun” ( p < 0.0001).

The mean divergence between VAS and WOMAC weight-bearing pain did not vary significantly with KL grade ( P = 0.72), but a highly significant trend was found for larger mean divergence in VAS and WOMAC non–weight-bearing pain with increasing KL grade ( P < 0.0001) (Figs. 3 A–C). 4.

There was a highly significant variation ( p < 0.0001) between the two settings in reported answers on handwashing after touching raw chicken—while 90.4% of respondents in Egypt indicated they washed their hands with soapy water, only 27.2% of respondents in Iraq indicated doing so.

The highly significant regression model was verified by a low P value ( P < 0.0001), which should be less than 0.05 [ 28 ].

The correlation between the five categories was highly significant for pain relief (P <0.0001), though not significant for reduced dysfunction.

rmANOVA regarding response time showed a highly significant main effect of order, F (2, 38) = 12.13, p ≤ 0.0001, but not regarding condition, F (1, 19) = 1.36, p = 0.26, as well as no interaction effect of order and condition, F (1.24,23.56) = 0.22, p = 0.7.

While an increase in the number of symptoms was noted in both the vaccinees and untreated controls throughout the experiment, the differences in number of clinical signs were highly significant, both between treatments (ANOVA, p < 0.0001) and between times (ANOVA, p < 0.0001).