“highly significant”

In line with the Kaplan–Meier analysis, cf-miRNA levels were highly significant for OS in both univariate (HR 1.89, P = 0.00007) and multivariate (HR 1.83, P = 0.001) analysis (Fig. 1c and Supplementary Table 1 ), confirming that total cf-miRNA is an in the independent prognostic marker for survival in OC.

Across all tumor types, there was a similar range of cell viability when comparing Collagenase I and Collagenase IV, with mean viabilities of 25.18 ± 6.23% and 66 ± 15.51%, respectively, demonstrating highly significant differences ( p = 0.00007; pairwise Wilcoxon rank-sum test).

1 shows that, although the sex effect was highly significant ( p = 0.00007) (Additional file 1 : Table A.2), males and females were distributed throughout the plot with no clean separation.

Statistical analysis confirmed that the AMP+ATZ combination was highly significant ( p = 0.00007) compared to the ATZ-only treatment, demonstrating the synergistic interaction between AMPs and ATZ.

This highly significant oxidation of the cytosol (p value = 7 × 10 -5 ) is dependent on NOX2 activity, but independent of the most effective thiol oxidant produced in neutrophils, MPO-derived HOCl.

As an illustration, taking a case with 5 TDLU with negative staining, 5 of sporadic pattern at intensity 2, 5 of sporadic pattern at intensity 3 and 10 with a 'ring-like' pattern at intensity 1 results in a score of 20 x 0 + 20(2 + 1 + 1) + 20(3 + 1 + 1) + 40(1 + 2 + 1) = 340 Twenty-five cases were examined independently by two observers and the scores obtained showed a significant con- cordance (t = 0.723, P = 0.00003, Kendall Rank Correlation). Intraobserver correlation was also highly significant (T = 0.96, P = 0.00007).

The difference between the two groups was considered highly significant, as the sum of chi square values comparing the two groups was 19.07 and p = 0.00007.

The model demonstrated strong predictive performance (AIC = 679.94, concordance index = 0.84) with a highly significant global log-rank p-value (p = 7.07 × 10 -5 ).

First, we investigated the possible role of DRB1*03:01 in MS susceptibility and we observed a highly significant effect: OR = 1.52, 95% CI 1.23–1.88, p = 7.1*10 −5 .

However, we detected highly significant linkage disequilibrium for 3 nuclear locus-pairs across populations after a sequential Bonferroni correction for k tests ( k = 703, p < 7.1 × 10 -5 ): One_MHC2-190 ( I = 0.433) and One_MHC2-251 ( I = 0.465); One_Tf_ex10-7 ( I = 0.632) and One_Tf_ex3-18 ( I = 0.084); One_GPDH ( I = 0.668) and One_GPDH2 ( I = 0.082).

We observed a highly significant causal effect of MCP on AD [IVW (OR = 1.12, 95%CI = 1.06‐1.18, p = 7.14 x 10 ‐5 )].

5A , the triple combination of enalapril (3.0 mg/kg), furosemide (2.0 mg/kg) and amlodipine (1.0 mg/kg) could decrease the MBP by −18.34 mmHg ± 2.75 mmHg, which was highly significant in comparison to placebo effects ( p = 0.000073) but narrowly missed the therapeutic goal of −20.4 mmHg (averaged MBP increase induced by renal interventions, pre RW versus week 14–58).

The effect size ratio is highly significant (OR 1.60, 95% CI 1.27 to 2.02, p=7.36×10 −5 ).

The observed count is therefore highly significant ( p = 7.4 × 10−5).

Abundance estimates provided by RepeatMasker showed highly significant positive correlation with those yielded by RepeatExplorer in both the Southern (Spearman r s = 0.84, N = 15, P = 0.000074) and Northern (r s = 0.97, N = 17, P < 0.000001) lineages.

The pooled difference between Sr6 positive and null plants at 18 °C was highly significant ( p = 0.000074), whereas no significant difference was observed at 25 °C ( p = 0.75) (Fig. 2B ).

ANOVA analysis revealed a highly significant effect of temperature on the immobilized enzyme, with a large F-statistic [F(9,20) = 7.75] and a very low P-value (p = 7.48 × 10 −5 ) (Supplementary Table 3 a and 3 b).

6 G), obtained by stratifying lung cancer patients into low or high risk strata depended on four model gene expression, presented highly significant survival differences ( p = 7.5e-5).

For the H3K4me3 mark, the separation at the level of PC1 = 0 was highly significant (p = 7.6x10 -5 , Fig 2A ), but not at lower PCs (see PC1 to PC5 in S3 Fig ).

The correlation between the NME close to the TSS and the gene expression variability was highly significant (Pearson correlation test, average correlation = 0.23, average 95% CI = [0.21, 0.25], average P = 7.6 × 10 −5 ).

The probability of all eight of the low MOI lineages going extinct, but none of the others, was highly significant (one‐tailed Fisher's exact test, df = 1, P = 7.7 × 10 −5 ).

Single peak promoters in our filtered dataset of 4,481 promoters had highly significant (Fisher's exact test, Bonferroni-corrected p-value < 7.8E -5 ) enrichment for the TATA-box binding motif, a confirmation of previous findings [ 8 ].

As shown in Table 3 , the PT1 group revealed highly significant differences from baseline to 3 months for Shannon index ( adj. p = 0.000078), observed species ( adj. p = 0.000025), and phylogenetic diversity ( adj. p = 0.000001).

This difference between SNP types was highly significant (GLME with binomial family of error distribution, LRT against null model, p ‐value = 7.874699e−05).

We observed a highly significant overlap between the DE genes from the two studies, using either a rank-rank hypergeometric overlap test (p = 7.9 × 10 −5 ; Methods), or a standard hypergeometric overlap test for genes DE at p < 0.05 in both studies (p = 2.03 × 10 −25 ).