“highly significant”

Considering IC 50 value, NHFMEWF (156.32 ± 1.32 μg/mL) was estimated to be just around 50% less potent than that of acarbose (103.77 ± 1.02 μg/mL) in inhibiting α-amylase, which was also analyzed to be highly significant ( p = 0.000063) in contrast to the acarbose.

In contrast, a highly significant difference was observed in adenocarcinoma growth patterns ( p = 6.30 × 10 −5 ).

the lesion) with HYV frequencies ranging from 60–63%, all of which are highly significant ( P < 6.3e-5; Figure 4B ).

This implies 5.3-fold highly significant (p = 6.3×10 −5 ) excess of the observed associations compared to those by chance.

While pathway analysis did not identify any canonical pathways to a high level of significance, chemotaxis of eosinophils was identified as a highly significant function ( P = 6.4 × 10 -5 ) (see Additional file 7 ), and eosinophil levels correlated well with RNAs for all of the aforementioned chemokines and cytokine (see Additional file 11 ).

We observed highly significant excess of CD missense URVs in EE/DEE (Fig. 1a , P = 0.0000643, OR = 1.09), whereas there was no significant excess of the other missense/inframe URVs ( P = 0.0861, OR = 1.01).

More specifically, the associated marker IAAV416 of QLyc.sxau-7A.2, located at 712.42–713.74 Mb, exhibited a highly significant level (− log 10 ( P -value) = 4.19–6.86), indicating the presence of genes that regulate lycopene at these loci (Table 2 ).

Both 2361.8560 m/z and 2528.8833 m/z remained highly significant ( p = 6.57 × 10 −5 and 1.1 × 10 −5 , respectively) indicating that loss of these structures is associated with loss of gland differentiation in early stage PCa.

Several of the genes that showed RpoN-dependent expression in root nodules also contained a highly significant ( p -value ≤ 6.58 × 10 −5 ) RpoN binding sequence in their promoter region: the promoter of Bphy_0256, coding for nitrogen regulatory protein P-II ( glnB1 ), which is localized upstream of the ammonium transporter gene ( amtB ) ( Figure 3 A, Table 3 ); the promoter of the glutamine synthetase encoding gene (Bphy_1481, glnA ); followed by two genes of the 2CRS NtrBC ( Figure 3 B), which were also present among the 322 top down-regulated genes.

The divergence within each group is not statistically significant (divergence within CQS subsets Wilcoxon test, P = 0.35- Figure 2 C; within CQR subsets Wilcoxon test, P = 0.43- Figure 2 D), while the divergence between the groups is highly significant (Wilcoxon test P = 6.61 × 10 −5 , Figure 2 A and B).

We therefore re-analyzed the genome-wide expression profiles (Gene Expression Omnibus accession number GSE21260 ) of several different uninfected KC cultures and hrHPV+ KC cultures reported previously [10] by Ingenuity Pathways Analysis (IPA) and found a highly significant enrichment of genes belonging to the protein ubiquitination pathway ( Table S1 ; p = 6.69×10 −5 ).

At the group level, the ΔPSEs were highly significant for the ASD group (red bar, Figure 2B ; t 17 = 5.2, p = 6.7∙10 −5 , Cohen’s d = 1.23, 95% CI = [0.6, 1.84], t -test), and smaller, but still (albeit marginally) significant for the control group (blue bar, Figure 2B ; t 19 = 2.1, p = 0.047 Cohen’s d = 0.47, 95% CI = [0.006, 0.93], t -test).

Lastly, comparison of all MS patients with HC showed a highly significant decrease of MMP3 ( P = 6.77 × 10 −5 , q = 0.067) in MS subtypes compared to HC (Fig. 5 & Table 3 ).

p -values were Bonferroni-adjusted for multiple comparisons, with associations deemed potentially causal at p < 0.05 and highly significant at p < 6.8 × 10 −5 .

More recently, whole-genome sequencing revealed a highly significant ( p = 0.000068), abnormally high proportion of pathogenic MYH6 variants observed in 197 patients with HLHS (vs. 813 controls) [ 13 ].

In the large group of muscle-enriched exons studied here, we found a highly significant correlation of ugcaug frequency with muscle expression ( P = 6.8 E −05).

explains 13.67% of variation in , the spread of the early rings, and is highly significant (p = 0.000068) while explains more variability at 19.01% but was much less significant (p = 0.0593).

There was a highly significant correlation of the raw RNA output (R = 0.99, p- value = 6.9e-5), demonstrating inter-assay concordance.

In particular, the top nine pathways (most highly significant (p< 6.93e-05) were: microRNAs in cancer (hsa05206), endocrine resistance in cancer (hsa01522), EGFR tyrosine kinase inhibitor resistance (hsa01521), FoxO signalling pathway (hsa04068), hepatitis B (hsa05161), pathways in cancer (hsa05200), proteoglycans in cancer (hsa05205), breast cancer (hsa05224) and human papillomavirus infection (hsa05165).

Data 4 ), which represents a highly significant intersection ( p = 0.00007, hypergeometric test).

3 ; Additional file 9 ), a highly significant expansion was found on the branch leading to Euascomycetes (p = 7 × 10 -5 ).

Results The SNP rs1635529 for COL2A1 on 12q13.11 showed highly significant over-transmission to affected individuals (p=0.00007).

Across all tumor types, there was a similar range of cell viability when comparing Collagenase I and Collagenase IV, with mean viabilities of 25.18 ± 6.23% and 66 ± 15.51%, respectively, demonstrating highly significant differences ( p = 0.00007; pairwise Wilcoxon rank-sum test).

As an illustration, taking a case with 5 TDLU with negative staining, 5 of sporadic pattern at intensity 2, 5 of sporadic pattern at intensity 3 and 10 with a 'ring-like' pattern at intensity 1 results in a score of 20 x 0 + 20(2 + 1 + 1) + 20(3 + 1 + 1) + 40(1 + 2 + 1) = 340 Twenty-five cases were examined independently by two observers and the scores obtained showed a significant con- cordance (t = 0.723, P = 0.00003, Kendall Rank Correlation). Intraobserver correlation was also highly significant (T = 0.96, P = 0.00007).

Statistical analysis confirmed that the AMP+ATZ combination was highly significant ( p = 0.00007) compared to the ATZ-only treatment, demonstrating the synergistic interaction between AMPs and ATZ.