“highly significant”

In addition, a highly significant (p=0.00006) 1.6-fold elevation was seen in lactoylglutathione lyase (glyoxalase I, GLO-1) in Alkbh7 -/- vs.

The combined data ( Tables 7 and 8 ) reveal a highly significant association ( P =0.00006) with an OR of 3.06 (95% CI: 1.74–5.3) for patients carrying at least one variant allele (CT or TT) compared with the homozygous wild-type CC genotype, and therefore this increased risk applies to ∼56% (132/236) of breast cancer patients.

The cross‐tabulation between PAP and hr‐HPV outcome has demonstrated a highly significant association ( p < 0.00006; Table 2 ).

Associations of the TIRAP gene haplotypes with ALI risk We next carried out haplotype analysis on the basis of these two associated SNPs and found that a two-allele model of risk provided the strongest predictor of risk, which was highly significant (P = 0.00006 in ALI group vs control group and P = 0.00003 in ALI group vs sepsis alone group).

Our study indicates that ffEVs influenced the expression of various genes related to the MAPK pathway (GO:0032873, GO:1900744) in the Cp COCs group, which was also characterized by a highly significant increase in expansion during IVM ( p = 0.00006).

After repacking of modeled structures, which led to structural fitting of contacting residues and displacement of their side-chain groups, the correlations of steric descriptors became weaker, while the correlations of hydrophobic descriptors still remained highly significant (p-value = 6x10 -5 ). 3.4 Identifying residue binding features in CDR3: peptide interface using machine learning At the final stage we performed RFE (Recursive Feature Elimination) analysis and applied the Random Forest (RF) algorithm to make predictive models for the per-residue contacting energy values for amino acid residue pairs in CDR3 loops and peptides.

Specifically, the differentially expressed genes found between T10 and T20 in the pituitary only included 1 enriched GO term “neurohypophyseal hormone activity”, while the biological process of “response to steroid hormone” was highly significant ( p = 0.00006) before FDR correction but not after (FDR = 0.16181).

Conversely, in the case of IC7 with bilateral entorhinal cortex involvement, the IC expression demonstrated a highly significant association only with age ( t = 4.05, p < 0.00006) and the association with Aβ attenuates substantially to a statistically insignificant level.

Further, an alternative χ 2 test comparing the null expectation of no association between head-to-head competitions and ranked attraction index revealed this association was highly significant ( P = 0.00006).

The increased accuracy of the microbiome classifier was highly significant by bootstrap analysis ( p =6×10 −5 and p =.0001 compared to the clinical/demographic and combined brain classifiers, respectively; there was no significant difference between the clinical/demographic and brain classifiers) (Fig. 2 A).

Predictive value of biomarkers and clinical variables on cumulative ICU survival ICU survival at 28-day was associated with highly significant values of IL-1RA serum levels ( P = 0.00006, HR 1.31, 95% CI 1.15–1.50) and SOFA score ( P = 0.001, HR 1.18, 95% CI 1.07–1.30) in septic patients.

AA who group with European ancestry individuals in cluster 2 exhibit a highly significant ( P = 6×10 -5 ) trend of increased proportions of European admixture compared with AA grouping in cluster 1 ( Figure 2 B ).

In comparison to the most common haplotype 1112, fasting insulin levels and HOMA-IR values of haplotypes 1221 and 2221 were significantly higher and lower, respectively ( Table 1 ), and the difference between 1221 and 2221 was highly significant ( P = 0.00006).

For the TCGA data set, the correlation was decreased somewhat (Pearson r = 0.25 compared to 0.36 for the full data set) but still highly significant ( P = 6 × 10 -5 ), demonstrating that the correlation with age is only partially explained by IDH1 status.

We identified altogether five such positions (with P < 6 × 10 −5 , binomial distribution; i.e., highly significant) all of them occurring in the metazoan 18S rRNAs.

Cited2 −/− embryos showed a modest yet highly significant decrease in levels of Lmo4 mRNA when compared with wild-type littermates (1.35-fold decrease; P = 0.00006, n = 12 Cited2 +/+ vs. n = 12 Cited2 −/− embryos), but Lmo4 −/− embryos did not show any difference in Cited2 levels (n = 12 Lmo4 +/+ vs. n = 12 Lmo4 −/− embryos; Fig. 5 a,b), indicating that Lmo4 is downstream of Cited2 .

Three such modules (red, ivory, and light yellow) showed highly significant correlation with the MeJA treatment (Pearson r = 0.75—0.88; p = 6.04E−05–2.03E−09; Fig. 6 A; Supplementary Table S7 ).

However, after controlling for the single-gene effect, the partial correlation between TCL and cancer risk is still highly significant (Spearman’s ρ = −0.69, P = 6.10 × 10 −5 ; fig.

Deleting or duplicating sleep risk genes is associated with autism risk Pooling the MSSNG and SSC datasets yielded highly significant enrichment of insomnia risk (OR = 1.7, 95% CI = 1.5–2.0, p = 6.1 –05 ) and circadian pathway deletions (OR = 4.0, 95% CI = 3.4–4.6, p = 1.3 –05 ), and circadian duplications (OR = 1.8, 95% CI = 1.5–2.1, p = 4.4 –05 ), in ASD compared to controls (see Fig. 3 and Table S6 ). 95% CI of these ORs obtained by bootstrapping confirmed these results (Table S6 ).

Highly significant MTAs (P < 0.000061) under heat stress conditions were identified for flag leaf area ( xwmc336 ), spikelet per spike ( xwmc553 ), grains per spike ( cxfa2147 , xwmc418 and xwmc121 ), biomass ( xbarc7 ) and grain yield ( xcfa2147 and xwmc671 ).

This led the authors to assign scores of very low quality despite highly significant indications of efficacy of LOLA (RR 0.70, 95% CI 0.59, 0.83, Z = 4.01, p < 0.000061).

The improvement from geno2pheno-C Sanger to geno2pheno-C NGS–Sanger + was highly significant ( p -value = 6.22e – 05), while it was only significant at significance level α = 0.11 or higher for the improvement from geno2pheno-C Sanger + to geno2pheno-C NGS–Sanger + ( p -value = 0.11).

The proportion of direct target genes misregulated in fd-3 seedlings is highly significant according to the one-sided Fisher’s exact test (p = 6.257 × 10 −5 ).

The results obtained show that the differences are highly significant for genes ORF1ab ( p = 6.291 × 10 −5 ) and N ( p = 0.00329), while for gene E differences are only close to significance ( p = 0.0672).

Our analyses show that the linear relationship between the two variables is highly significant (b 1 = 4.65; F (1,10) = 43.2; P = 6.3 × 10 -5 ), with a determination coefficient for b 1 of R 2 = 0.78.