“highly significant”

Especially, apparent is the highly significant decrease for the mean head‐directional firing rate ( Z 65 = −4.053, P = 5.1e‐05) and its loss in correlation between sessions (Fig. 4 f).

We observed highly significant associations between CD40 expression and the rs4810485 genotype in all B cell subsets (patients: P ≤ 5.10 × 10 −5 , controls P ≤ 4.09 × 10 −6 ), with each copy of the multiple sclerosis risk allele rs4810485*T corresponding to lower CD40 cell surface expression levels ( Figs 1 and 2 ).

Of note, BABAM1 is the most highly significant CNV associated locus following full statistical correction of population stratification (p = 5.16×10 −5 ).

The ANOVA detected a highly significant ( F (1,66) = 18.73 , p = 5.2 e – 05) interaction between the carrier factor and the sonicated LGN side (left or right LGN).

pruinosus population, the overall results of the proportion of individuals (pc) showed a highly significant treatment effect (χ 2 = 29.338, df = 6, p = 5.25 × 10 −5 ), indicating strong behavioural modulation in response to LDPE leachates ( Table 1 ).

The difference in errors between shallow (LIPd: −0.2 ± 1.4% [P = 0.86]) and deep (LIPv: 15.7 ± 3.4% [P = 6.1e-05]) injections was highly significant (P = 5.3e-05, two-sided permutation test).

Notably, Cryptosporidium was detected exclusively in Chinese blue-tailed skinks, with its prevalence showing a highly significant difference between the two hosts ( p = 5.32 × 10 −5 , Fisher’s exact test).

The IVW regression showed a highly significant association between the 11 SNPs used as genetic instruments of exposure and risk of developing MM (coeff = 1.175, 95% CI 0.61–1.75, P = 5.38 × 10 −5 ), whereas the MR-Egger regression showed a statistically non-significant association (coeff = 0.532, 95% CI −1.16 to 2.22, P = 0.538), although in line with IVW regression, with the intercept slightly, but not significantly, different from zero (intercept = 0.06, 95% CI −0.09 to 0.20, P = 0.428).

The highly significant association is replicated ( P = 5.4 × 10 −5 ) with an estimated OR of 1.9 (95% CI, 1.2-2.6).

Patients with multi-site cancers demonstrated a notably higher cumulative incidence of irAEs compared to melanoma patients, with the difference being highly significant ( P = 0.0000546).

While the enrichment of the mTOR signaling KEGG pathway (hsa04150) was not statistically significant, the enrichment of genes from a manually curated mTOR signaling network [57] was highly significant in our dataset (p = 5.5×10 −5 ).

Lists of representative genes involved in particular GO terms in each contrast are presented in Additional file 5 . “Luteal regression over luteolysis”: GO terms having highly significant association with genes upregulated in the luteal regression group are: extracellular matrix ( p = 5.52e-05) and matrix organization ( p = 0.001), steroid hormone mediated signaling ( p = 2.29e-04) and steroid hormone receptor activity ( p = 1.63e-04), regulation of gene expression ( p = 7.40e-04), negative regulation of transcription from RNA polymerase II promoter ( p = 5.02e-05), and regulation of transcription, DNA-templated ( p = 2.45e-04), as well as positive regulation of epithelial cell proliferation ( p = 3.4e-03).

The comparison of patients carrying TP53 mutation ( TP53 -mut) to patients without TP53 mutation ( TP53 -wt) revealed a highly significant association between TP53 mutations and higher age ( P =5.54 × 10 −5 ; median age at sampling 69.3 for TP53 -mut and 62.4 for TP53 -wt; Figure 2a ).

We discovered that there was a highly significant over-representation of genes involved in development amongst spatially clustered T-DMRs that are hypomethylated in MBCs versus CVS (p = 0.00005574).

We calculated GRO-seq read counts near active and inactive CEBPB-bound sites based on the CRE-seq data and observed a highly significant enrichment in GRO-seq signal at active sites compared to inactive binding events ( P = 5.65 × 10 −5 ) (Supplemental Fig. 7).

The KR motif occurs 562 times in this CNE set, representing a highly significant enrichment over shuffled versions of the motif (p = 5.7 × 10 -5 ), and when compared to control genomic regions and the entire human genome (Table 1 , Methods and Additional File 4 ).

In contrast, there was a large and highly significant increase of input resistance in the responses to hyperpolarizing current injections, it more than doubled over control values ( Table 1 ; one-way ANOVA, p = 5.9 × 10 −5 , row g, Table 3 ).

When these tumor groups were compared, highly significant increased PARTICLE levels were noted when the WWOX FRA16D was intact (Chi-square association p = 0.000059, Figure 1B ).

Statistical analyses performed on the mean area amplitude of posterior N2 (attentional selection negativity ) showed that the attention condition was highly significant (F [3,75] = 16.06, GG adjusted p < 0.000059) with larger negativities to pseudo-targets than stimuli sharing only space location with the targets, and to the latter than to non-targets (see mean amplitude values in Figure 4 ).

Distance was found to be highly significant in this model ( p = 5.92e‐05; Table 2 ).

Pearson correlation analysis indicated a positive and highly significant correlation between TDO2 and CYP19A1 ( R = 0.78, P = 5.96 × 10 –5 ), TGFb3 ( R = 0.88, P = 3.3 × 10 –7 ), HOXA13 ( R = 0.62, P = 0.003), COL1A1 ( R = 0.65, P = 0.002), COL1A2 ( R = 0.60, P = 0.005), COL3A1 ( R = 0.79, P = 3.95 × 10 –5 ), CCND1 ( R = 0.65, P = 0.002), IGF2 ( R = 0.79, P = 3.48 × 10 –5 ), and WNT4 ( R = 0.56, P = 0.011) ( Figure 8 ).

Specifically, the differentially expressed genes found between T10 and T20 in the pituitary only included 1 enriched GO term “neurohypophyseal hormone activity”, while the biological process of “response to steroid hormone” was highly significant ( p = 0.00006) before FDR correction but not after (FDR = 0.16181).

All seven SNPs of the CEP68 gene showed linkage disequilibrium (LD), and the haplotype of CEP68_ht4 (T-G-A-A-A-C-G) showed a highly significant association with aspirin intolerance (OR = 2.63; 95% CI = 1.64–4.21; P = 6.0×10 −5 ).

For the TCGA data set, the correlation was decreased somewhat (Pearson r = 0.25 compared to 0.36 for the full data set) but still highly significant ( P = 6 × 10 -5 ), demonstrating that the correlation with age is only partially explained by IDH1 status.

AA who group with European ancestry individuals in cluster 2 exhibit a highly significant ( P = 6×10 -5 ) trend of increased proportions of European admixture compared with AA grouping in cluster 1 ( Figure 2 B ).