“highly significant”

Importantly, a comparison of 38 cancer cell lines found a highly significant correlation between high integrin β3 gene copy number and neratinib (Pearson correlation coefficients: 0.614, p -value = 4.12 × 10 −5 ) or lapatinib (Pearson correlation coefficients: 0.436, p -value = 1.13 × 10 −2 ) resistance ( Figure 2 E).

When these datasets were combined in our statistical model (see methods), differences between apical and basal dendrites were highly significant ( p = 4.14e-05, Additional file 5 , Fig. 4 g).

Other highly significant pathways with a positive z-score were related to dendritic cell function and neuroinflammation, namely dendritic cell maturation (−log( p -value) = 4.37, z-score = 1.00) and neuroinflammation signalling pathway (−log( p -value) = 3.71, z-score = 2.00). 3.4.

We confirm the previously published association of the lead variant in the total sample, with the association for DBP still being highly significant in the UKB data alone ( P = 4.27 × 10 −5 ; N = 423,655).

The moderate and highly significant positive correlation between Mcl-1 and USP9x immunoreactivity (Spearman’s r = 0.560, p = 0.000043; Pearson’s r = 0.510, p = 0.00025) proposed an interrelation between the anti-apoptotic protein Mcl-1 and the deubiquitylating enzyme USP9x in prostate cancer. 3.2.

1a ) was also highly significant ( P = 4.4 × 10 − 5 ).

In the combined study and after correcting for multiple testing, there was a highly significant association of C4A copy number with AMD ( P = 4.4 × 10 −5 , P corrected = 1.3 × 10 −4 , Fig. 2 ).

The intergroup difference for this finding was statistically highly significant (p = 0.000044).

The full regression model was highly significant ( R 2 = 0.45, f (6,48) = 6.5, p = 4.43 × 10 −5 , robust multiple linear regression; for variation inflation factors see Supplementary Fig. 2 ).

We also re-ran the model, including average mean diffusion in the TBSS-derived skeleton as an additional predictor, which had minor effects on the results, reducing the p-value for atrophy slightly (0.031), while retrieval activity was still highly significant ( p = 4.46 e −5 ) and R 2 (adjusted) = 0.237.

For the plastic bag-samples, a highly significant difference between the reference material and the two obtained samples (plastic bag-metal and plastic bag-no metal) was observed (1-way ANOVA, F = 12.9, p = 4.5 × 10 −5 ), while the means of the two plastic samples showed no significant difference (post-ANOVA Tukey-test, p adjusted = 0.11).

We found that the expression of IL2RG, used by all common gamma chain cytokines, exhibited a highly significant upregulation pattern in SIV compared to control ( p = 0.000045), and in SIV/Meth compared to SIV ( p = 0.0001).

There was thus a highly significant association between flight performance in the cage and outside (Fishers exact test: two-tailed P = 0.0000452).

Apart from immunity and defense ( P = 5.84×10 −11 ), other highly significant biological processes highlighted include chemokine and chemokine-mediated signaling ( P = 4.53×10 −5 Table 3 ).

The results are shown in Figure 2 , with the probability of belonging to the Dent and the Flint groups for each parental line (Figure 2 A) and the highly significant correlation ( P value = 4.6 × 10 -5 ) observed between the GWRR in a population and the average 'flintness' of its parents (Figure 2 B).

The P-value is highly significant when corrected for multiplicity (207 sites, Bonferroni corrected P-value = 4.6e-5).

Linear regression with parameters as predictors was highly significant, but accounted for a far smaller amount of variance than the synthetic data (adjusted r 2 = 0.36, p = 4.6E-5).

Crude rates in PMRT were 22.5% for prepectoral reconstruction (25/111), 62.9% for submuscular DTI (22/35), and 39.1% for expanders (9/23), with a highly significant overall difference (global χ 2 p = 4.61 × 10− 5 ).

The difference in this increase in nuclear enrichment upon exercise between HITT and TRAD was 1.89 and highly significant ( P = 4.7 × 10 −5 ; Fig. 6 C , SI Appendix, Fig.

Further examination of the tumor tissue sections after anti-PD-1 therapy revealed the co-localization of mast cells and FOXP3 + Treg cells, which was consistently observed and highly significant ( p = 0.000047) when compared to control-treated tumors (Fig. 4e ) and this may be associated with downmodulation of HLA class I on tumor cells (Fig. 3g, h, f ).

50 synonymous), and highly significant G -test results ( G = 15.20, P = 0.000048).

Using a logistic regression on the model ln(w ij /(1−w ij )) = a+b ln(P i P j ) , we observe a highly significant negative correlation between confirmation probability w ij and log-transformed popularities of the interaction partners ( a = −1.41±0.04; b = −0.020±0.005, p = 4.8*10 −5 ; N = 62,864 statements).

Meta-analysis of the 2 cohorts yielded highly significant evidence of association with JIA (OR 0.76 [95% CI 0.62–0.88], P = 4.9 × 10 −5 ).

As expected, we observe stronger average absolute correlation in the ISO-treated cohort ( R = 0.174 vs 0.111), and that while the control cohort’s correlations of the adrenergic signalling pathways with Serpina3n were not significantly higher than expected ( p = 0.728), the correlation of Serpina3n expression with the ISO cohort was highly significant ( p = 4.9 × 10 −5 ).

There was a highly significant effect of regions (linear mixed model, P = 0.000049).