“highly significant”

This SNP remained highly significant upon conditioning on the previous RA risk variant (rs394581, P =2.2 × 10 −5 ) or on a SNP previously associated with celiac disease and type I diabetes (rs1738074, P =1.7 × 10 −4 ).

In this model (adjusted R 2 = 0.73), sample size had no significant effect on α ( β = −1.2e-04, p -value = 0.48), whereas IGRs showed a highly significant positive shift ( β = 0.137, p -value = 2.2e-05).

Post-Hoc analysis by Pairwise T-Test with Bonferroni-adjustment showed that there was a highly significant reduction in the ABZ and ABZ/BTZ-treated group as compared to the control (p = 2.2e-05 and p = 1.3e-06, Figure 8B ).

This enrichment of previously described vaccine candidates in our Vacceed set was highly significant (one-tailed Fisher’s Exact Test – P = 2.2 × 10 −5 ).

A highly significant ( p = 2.2 × 10 −5 ) OPLS model could be built for the classification of samples by production year (model 8).

While One‐way ANOVA tests indicated minor statistical variations among the samples within the same channel (p = 0.0132 for the 1.0 mm channel; p = 0.0035 for the 1.6 mm channel), these maximum deviations (∼0.27 mm/s) were negligible compared to the highly significant performance shifts induced by variations in the environmental geometry (an absolute speed difference ranging from 1.8 to 2.3 mm/s, p = 2.27 × 10 −5 when comparing the pooled sample data between the two channels).

Expression of GABA-related genes positively correlates with viral load The effect of DWV load on GABA-related gene expression was highly significant in GR bees (GLM, MB DWV log 10 ; β est.=0.473, s.e.=0.108; t =4.365, P =2.28×10 −5 ) while this was not the case for BR bees (GLM, DWVlog 10 ; β est.=−0.248, s.e.=0.134; t =−1.849, P =0.067).

For CS- tones, a highly significant increase in SSA occurred after conditioning ( Fig 4F , 16%, F(1,1801) = 18, P = 2.3*10 −5 ).

We employed standard ANOVA F-tests [ 59 ] to evaluate the significance of the interaction term (reflecting varying slope by treatment group) and found that the evidence did not support inclusion of the interaction term (P = 0.93) when comparing these two models, but when comparing the simpler model to the trivial model that ignores treatment group (adjusted R 2 = 0.75), the ANOVA F-test P-value is highly significant (P = 2.3e -5 ), supporting the inclusion of group-specific intercepts, but not group-specific slopes, in the final model.

We observed highly significant effects in men (effect size or ES=(M TLS −M MLS )/SD pooled =1.15, p=2.3×10 −5 ) and women (ES=1.25, p=8.2×10 −4 ) in the expected direction corresponding to a three times higher consumption of game intake in those with a traditional lifestyle.

When testing the same networks with the top 900 and 850 strongest connections retained, E glob remained highly significant ( p = 2.31 × 10 −5 for 900 and p = 3.07 × 10 −5 for 850 links).

This increase of GSH plasma concentration was highly significant already after 1 h of preparation delay (paired Student’s t -test p -value = 2.34 × 10 −5 , Figure 1 A, left panel).

Nevertheless, the correlation between genetic diversity and geographic distance from Asia remained highly significant after controlling for the number of infections [generalized linear models (GLM), P < 2.37 × 10 −5 ].

The analysis demonstrated a highly significant increased effect size when stimulation was applied to subcortical strokes versus the mixed strokes ( p = 2.45598e−05, two-tailed Mann–Whitney U -test.) When sub-analyzed within the context of type of stimulation technique, this significant finding was reproducible for both rTMS and tDCS articles (rTMS p = 0.01115294 and tDCS p = 0.01428572, Mann–Whitney two-tailed U -test).

The coastal southern part of Cameroon had the lowest Bd burden with a highly significant decrease of cases over time (odds = 0.4, P -value = 2.5 × 10 –5 , Table 1 ).

The log-rank test showed a highly significant difference in MFS between patients with low (⩽0.81, n =62, 26.6%) and high (>0.81, n =171, 73.4%) ATM protein levels ( P =0.000025; Figure 1B ).

A linear model of incidence by commune on both IDH and Amerindian ancestry showed that HDI remained highly significant (p < 2.55e−05).

Pentapeptide-sharing was found to be highly significant between schizophrenia-related proteins and the hemagglutinin precursor (χ2 (1) = 17.723, p = .000026, two-sided).

As expected, the LAMP analysis revealed highly significant evidences for both linkage (LOD = 5.19, p = 2.6×10 −5 ) and association (LOD = 45.88, p = 7.2×10 −48 ), and both the evidences are mapped to the HLA-Cw6 locus.

3e ) the slope of the regression line was highly significant (F 1,1082 = 17.83, r = 0.179, p = 2.6 × 10 −5 ), as was the increase of the post-training slope relative to the pre-training one (F-test, F 1,2288 = 15.31, p = 0.0001).

The main effects of qDH3 , qDH6 , and qDH7 were highly significant (3.8 × 10 −15 < p < 2.6 × 10 −5 ) in both 2016 and 2017.

The correlation with OS was highly significant: HR = 2.2 (1.51–3.21) with 95% CI (log-rank p -value = 2.6E−05).

Its first component was found to have a highly significant correlation ( r = 0.77, p = 2.62 * 10 −5 ), as well as a steep relationship to PMA (slope a = 0.88), suggesting that global properties of the connectivity might also reveal robust developmental correlations.

Of all 1540 possible gene pairs, we found that a total of 226 pairs were significantly enriched beyond what would be expected by chance (hypergeometric test, Benjamini-Hochberg–adjusted, P < 0.05), with highly significant pairs such as Cdkn2a + Pten (co-occurrence rate = 7/10 = 70%; hypergeometric test, P = 2.63 × 10 −5 ), Cdkn2a + Rasa1 (co-occurrence rate = 6/9 = 67%; P = 7.96 × 10 −5 ), Arid2 + Cdkn1b (co-occurrence rate = 11/17 = 65%; P = 9.13 × 10 −5 ), and B2m + Kansl1 (co-occurrence rate = 11/18 = 61%; P = 3.6 × 10 −4 ; Fig. 5 , B and C, and table S13).

In contrast, a higher minor allele frequency (15.6%) of the p.Leu1007fsX1008 (rs2066847) frameshift mutation was seen in patients with aggressive disease, compared to 8.2% in patients with mild disease which was highly significant (p = 2.63x10 -5 , Table 2 ).