“highly significant”

A highly significant protective effect for HLA-A*02 : 01 was observed in females (OR = 0.63, p = 1.21 x 10 −05 ), while no effect was seen in males ( Table 4 ).

The reduced model 2 without the ‘taxon’ term gave a much worse fit to the data, resulting in a highly significant likelihood ratio test (χ 2 = 19.12, 1 df, p -value = 1.228 x 10 −05 ).

This first set of results was obtained with high levels of reproducibility, obtaining highly significant values when the data concerning treatments with R8-PNA-a221 and R8-PNA-a221-MUT are compared (p <0.0000123 in five independent determinations.

Replacing the RTK-RAS amplification with the RTK-RAS-MYC amplification in the Cox regression model controlling clinical features led to an increase of the R -square from 0.165 to 0.173, and both NFE2L2 mutation and RTK-RAS-MYC amplification were highly significant ( P = 1.25e−05 and 5.11e−4, respectively, Supplementary information, Table S16b ).

Among these, the former was also the most significant regulator in the KO group ( p = 5.68 × 10 −9 ), while PHIP was the highly significant and exclusive regulator in the KO group fed with ω-3 PUFA ( p = 1.26 × 10 −5 ).

In SW-1353 cells a highly significant down-regulation by 100 μM diacerein in the expression of cyclin B1 to 0.095 ± 0.03 ( p = 1.28E-05), CDK1 levels to 0.154 ± 0.02 ( p = 9.82E-06), and the CDK2 levels to 0.443 ± 0.12 ( p = 0.002) could be demonstrated.

This analysis confirmed a difference in functional hyperemia dynamics that remained highly significant in response to 40‐sec stimulations (visual, P = 1.28 × 10 −5 ; motor, P = 1.18 × 10 −6 ), but not to 20‐sec stimulations (visual, P = 0.133; motor, P = 0.431).

Moreover, we found a highly significant protective haplotype spanning ∼83 kb from intron 4 to the 3′ end of SNCA ( P = 1.29 × 10 −05 ).

We found that SD indeed led to a highly significant 4.8% loss in body weight (−1.3 ± 0.1 g; paired two-sided t -test; p = 1.3 × 10 −5 ; n = 9; Figure 4 A), despite mice having free access to food.

The study found a significant association for OS in NSCLC patients (P<0.05) and a highly significant association with smoker LUAD patients (HR 3.14, p = 1.3e-05) ( Table 4 and Figure 5A-D ).

Global Moran’s I analysis at the village level demonstrated weak-to-moderate but highly significant positive spatial autocorrelation of Q fever seroprevalence (Moran’s I = 0.15, Z = 4.3, p = 0.000013).

The association between vitamin D status and gender was highly significant ( p = 0.000013).

Two further general population cohorts, KORAF4 and SAPHIR confirmed the association, and a meta-analysis of all three cohorts (11,258 individuals) was highly significant (p = 1.3x10 -5 , OR = 7.46).

Supporting our in vitro findings, analysis of REs in metastatic CRPC tumors revealed a highly significant negative correlation ( r = −0.697, P = 1.3 × 10 −5 ) between levels of SUV39H1/H2 and MDA5-binding repeat RNAs in patients exposed to the antiandrogens Enz or abiraterone ( Fig. 5 C ).

A meta-analysis of all three cohorts (11,258 individuals) was highly significant ( p = 1.3 × 10 −5 , OR = 7.46).

GO analysis revealed highly significant clusters related to angiogenesis ( p = 1.32 × 10 −5 ) and vasculature development ( p = 1.01 × 10 −7 ).

Survival analysis based on the model risk score demonstrated a highly significant difference (P = 1.363e-05) in the training cohort ( Figure 6C ).

Focusing on cell adhesion, the focal adhesion pathway displays a small but highly significant positive association, which was detected in the liver ( p = 1.39 × 10 −5 ) and kidney ( p = 7 × 10 −4 ), and for cell adhesion molecules associations were found in the liver ( p = 9.71 × 10 −7 ), brain ( p = 0.02) and kidney ( p = 2.70 × 10 −6 ).

random cross-observer comparisons was highly significant (rank sum test; p = 1.4 × 10 −5 ).

The gene × gene interaction terms were highly significant, with VPS45 _KD × C1orf54 _KD ( β = 0.26, p = 1.4 × 10 −5 ) and VPS45_ KD × lncRNA _KD ( β = 0.16, p = 6.7 × 10 −5 ) positively correlated with the SNP editing effect ( Figure 6 J).

The statistical model revealed a highly significant template effect ( DoF = 4, F = 7.08, p = 1.42 × 10 −5 ).

The interaction network between the DAPs was highly significant ( p < 1.43 −5 ), indicating that the DAPs might be biologically relevant.

The random effect of rs29232 exhibited a highly significant P value of 1.90 × 10 −16 (OR = 1.47, 95 % CI = 1.34–1.61); however, the random effect of rs3129055 ( P = 1.43 × 10 −5 , OR = 1.28, 95 % CI = 1.14–1.42) did not exhibit genome-wide significance (<10 −7 ).

Together, the association between lncRNA upregulation and OS was highly significant (p = 1.432e-5) (Figure 2C ).

Similarly, the category “inflammatory response” is also highly significant among LASSO and ELASTIC NET results ( p = 1.44E−05).