“highly significant”

The advantage of KRR and KMER over RR is highly significant ( p = 1 × 10 −5 ; permutation testing), but the advantage of KMER over KRR is not significant ( p = 0.093).

At 0% the low α-diversity of phototrophs was highly significant to diversities at 20% (June) (t = −8.85, df = 12, p < 0.00001 ) and at 45% (December) intermittence (t = −8.4, df = 21, p < 0.00001 ) ( Table S5 ).

The differences are relatively constant across the subjects, and a paired student's t test returned a highly significant difference between the two conditions (P < 10 −5 ).

5 showed a highly significant difference for these pairs of groups, p < 0.00001.

Correlation analysis across six independent bulk transcriptomic cohorts (TCGA-PAAD, ICGC-PAAD-CAseq, GSE85916 , GSE79668 , GSE71729 , and EMTAB6134) demonstrated a highly significant positive association between THBS2+ CAF signature scores and T-cell exclusion scores (all p < 1 × 10−5), indicating that tumors with high THBS2+ CAF infiltration exhibit restricted T cell access to tumor nests ( Fig. 4 B).

Assessment of aCL Presence by Meta-Analysis Presence of aCL in dementia patients was highly significant compared to controls (OR: 4.94, 95% CI: 2.66–9.16, p < 0.00001; I 2 = 32%, p = 0.16) ( Figure 2 ). aCL was present in 32.80% of dementia patients and 9.50% in controls corresponding to 3.45 times higher probability to present with dementia than controls.

Faculties (JRs and BDS) and interns of medical and dental knew that BLS can be performed both inside and outside the hospital setup unlike the other groups, which showed the statistically highly significant P = 0.00001 (Q4).

In DHLF-COPD the Mann-Whitney U test showed a highly significant difference in distributions (U = 41246, p = 1.01 × 10 −5 ) and Mood’s Median Test confirmed a significant difference in medians (χ 2 = 15.82, p = 7 × 10 −5 ) comparing control and treatment group while in NHLF no significant correlation could be detected (Fig. 6 A).

The correlation between the ranking of amino acids of Figure 4 A and the one in Figure 5 E was highly significant (ρ = 0.81; p = 1.03 × 10 −5 ), despite the limited number of epitopes with available X-ray structures used to estimate amino acid frequencies in Figure 5 E.

Here, an equivalent time point comparison at 15 min revealed that CBD invoked a highly significant negative shift in Va from a baseline value in control recordings of Kv7.2 wt + Kv7.3 of −29.8 ± 1.25 mV to −35.6 ± 1.36 mV (n = 8; p = 1.06 × 10 −5 ) in CBD ( Figure 5 A).

The OPLS-DA model showed a good fit (R 2 = 0.65), predictivity (Q 2 = 0.55) and a highly significant CV-ANOVA ( p value = 1.1E −5 ).

We mapped the regional presentation score of the most highly represented protein in the neuroblastoma ligandome, NPY (29 MHC Class I peptides detected in 16 neuroblastomas), finding a highly significant concordance between the empirically detected peptides and those regions of the protein expected to be highly presented ( Figure 3E ; p = 0.000011), and find no peptides in the ligandome derived from the signal peptide region (aa 1–28) which is cleaved from the full-length pro-NPY protein.

Indeed, when we compared the South African and Canarian goats with the remaining populations, estimated F ST coefficients were moderate (F ST = 0.06–0.14) but highly significant ( P < 1.10 −5 ).

Under this model, the transition from Tanner breast stage 2 to 3 was associated with a highly significant increase in logit-transformed LAB proportions ( P = 1.1E-05), while subsequent transitions to stage 4 and 5 had relatively small effects ( P = 0.26 and P = 0.56, respectively [ Table 2] ).

The Wilcoxon rank-sum pairwise tests confirmed this trend within light settings: the differences between paired control and positive-trained groups were highly significant in all light conditions (G: Z = 4.395, p = 1.107 × 10 −5 , Holm-adjusted p = 2.214 × 10 −5 ; B: Z = 2.904, p = 0.004, Holm-adjusted p = 0.004; G&B: Z = 4.813, p = 1.484 × 10 −6 , Holm-adjusted p = 4.453 × 10 −6 ).

The P -value of the meta-analysis of 3 independent datasets was highly significant (mean OR, 0.4; P =1.11E-05), which indicates that hypercholesterolemia tended to occur in women without adenomyosis.

Finally, a PPI network analysis in the STRING confirmed a highly significant interactions, highlighting the biological interconnectivity of these genes (PPI enrichment p = 1.15e−05) ( Fig. 8I ).

We repeated this analysis removing the 19 known ASD/ID genes ( Supplementary Data 1 ) and observed a reduced but still highly significant signal ( P =1.17 × 10 −5 ) corresponding to an odds ratio of 4.1 (95% CI=2.2–7.0).

Interestingly, when assessing whether the sex of an individual contributes to its methylation level, we found a highly significant sex effect at VM-IAP Rnf157 whereby males are more likely to exhibit higher methylation levels than females (p = 1.20e−5; q = 2.16e−4; Figures 6 G, S5 B, and S5C).

Moreover, employing k-values from 2020 and 2021 to establish classification functions and 2022 k-values for cross-validation to predict sample classification, a highly significant discrimination ( p = 0.000012) was observed among EVOOs stored at different temperatures.

The 4-GES again predicted OS in a highly significant manner (adjusted p = 1.2 * 10 −05 and adjusted p = 5.6 * 10 −05 for cohorts 1 and 2, respectively; Fig. 2A,B ).

Assuming the population origin on the coast between NQLD and CQLD, we considered Mackay, the first port of entry for European settlers on the Australian tropical coastlands [ 38 ], and found a highly significant positive correlation between β st and distance from Mackay ( r = 0.91, p = 1.2 × 10 −5 , Figure 2 C).

Combining data from neuropathological and clinical replication cohorts revealed highly significant associations of all ten GAB2 variants (9.7×10 −11 <p<1.2×10 −5 ) with LOAD.

[ 34 ] described significantly lower levels of agalactosylated structures for IgG of the fetus (mean value of 13.1 %) as compared to maternal IgG (mean value of 16.7 %; difference of 3.6 % is statistically highly significant; p = 0.000012; see Table 4 ).

Still, re-analysis of the correlation between BAT volume and LysoPC-acyl C16:1 in discovery population showed that the correlation was still highly significant (p = 1.2 × 10 −5 ) when the BAT negative subject is included.