“highly significant”

This study showed that duration of analgesia was 37% higher for Bupivacaine which lasted for up to an average period of 7.3 hrs which was highly significant (p=0.00001*).

When implementing this bootstrapping approach, we find that the ability of the top genes to correctly order the cROIs is highly significant ( p < 0.00001).

The mean synonymous site nucleotide diversity ( π syn ) for X-linked genes (Tables 1 and 2 ; Additional file 1 : Table S4) is 0.00017, versus 0.0018 for all autosomal genes identified; the mean estimated nucleotide diversity for all sites ( π ) is 0.00038 for the X-linked region, again much lower than values for the autosomal region or PAR (0.0017 and 0.0020, respectively, which do not differ significantly (Wilcoxon rank sum P = 0.12), while the difference from the X-linked region is highly significant ( P < 1 × 10 −5 ) for both regions).

3G was highly significant ( P < 10 − 5 , Fisher’s exact test).

The differences were found to be highly significant ( t -test, p < 0.00001).

The highly significant similarity of gene expression from same-host papillomas suggested that germline polymorphisms affect constitutive levels of gene expression in benign tumors ( P < 0.00001 by permutation; see Materials and methods).

This difference was highly significant (p < 0.00001).

Interestingly, the genomic prediction accuracies based on only highly significant SNPs ( P < 0.00001, 318–400 SNPs for survival status and 1,362–1,589 SNPs for survival time) were somewhat lower (0.3–15.6%) than those obtained from the whole set of 6,470 SNPs.

As demonstrated by the high odds ratio (log 2 (OR)>6) between all the data sets, we showed that there was a highly significant overlap in RI (Fisher’s exact adjusted p<1e−05, Figure 1—figure supplement 2a ).

This search recovered the GCS2 HMM (based on PDB: 1r8g) as the highly significant best hit (p-value= 10 -5 ), with an alignment spanning the entire length of the GCS2 catalytic domain and matching all key conserved motifs (Fig. 2 ; see below).

The FLA demonstrated the shortest mean duration (10.88 ± 1.2 min), with a highly significant difference (analysis of variance F-test, P < 0.00001) compared to the eyebrow, bifrontal trans-basal, and pterional approaches.

Considering only INOCA patients, out of 38,987, only 195 (0.5%) experienced an adverse event related to ACh administration, while the incidence rate in the MINOCA population (34,319 pts) was 0.1%, configuring a highly significant difference among the two groups ( p < 0.00001). 4.

Between the Non-Gly and the Gly subtypes, we identified 763 highly significant Differentially Expressed (DE) genes (Adj. p < 1E-05), 296 of which over-expressed in Gly subtype and 466 over-expressed in the Non-Gly tumors ( Figure 2A and Supplementary Table 3 ).

The figure shows a positive, highly significant relationship ( r = .620, p <.00001), between these conditions, indicating that speakers generally accept Th-R orders vP-internally to the same, typically low, degree as they do under object shift.

The pooled analysis resulted in a highly significant difference in LDL-C changes relative to baseline between dapagliflozin and placebo [MD = 4.24; 95% CI (2.83, 5.64); P < 0.00001], with low heterogeneity (I 2 = 0%).

All primary outcomes showed significant improvement post treatment at BF-corrected alpha of p < .0028: There was a highly significant post-treatment drop of general psychiatric symptoms (SA-45 global severity index; p < .00001, d = 1.08).

A correlation matrix was calculated for these genes, using Pearson Product-Moment Coefficient, defined as r x , y = ∑ i = 1 n ( x i − x ̄ ) ( y i − y ̄ ) ( n − 1 ) δ x δ y The values of Pearson correlations above 0.3 are statistically highly significant (p-value < 0.00001 after Bonferroni correction for multiple testing [ 85 ]).

The test for overall effect was highly significant (Z = 4.52, P < 0.00001), with moderate heterogeneity observed across the trials (I 2 = 58%).

For a test, we conducted chi 2 tests for some of the variables, but, as assumed, all results were highly significant (e.g., “gender”: chi 2 : 695303.9042, p < .00001).

Inter-rater reliability was highly significant (Cohen's κ = 0.62; Z = 19.1; P << 0.00001; number of errors = 90).

For each variable, the correlation (Pearson coefficients) was highly significant ( p <.00001).

These data demonstrate a high degree of gene expression dysregulation in the peripheral blood of patients with FA with a highly significant ( P < .00001) skewing in favor of upregulated genes.

Regarding the percent inhibition of paw edema, the main effects of the treatment and time factors were highly significant by the four solutions used ( P <0.00001), and their interaction was also significant ( P =0.006, 0.006, 0.0062, and 0.0058 for Manly’s approach, Edgington’s approach, Still and White’s permutation of residuals and ter Braak’ methods, respectively).

In a European patient cohort study of 110 candidate polymorphisms, Hhex SNP rs1111875, a major risk factor in T2D, was found to be a highly significant risk factor (p<0.00001) for AD, but only with the accompanying GSTM3 (rs7483) SNP ( 171 ).

A Monte Carlo simulation determined that this is a highly significant overlap (p<1 × 10 −5 ) and peak heights at shared ATAC and CATaDa peaks show significant correlation (p<1 × 10- 16 , r 2 = 0.138) ( Figure 2—figure supplement 2A ).