“highly significant”

Furthermore, a robust association between observed and predicted responses for TC degradation was evident from the highly significant regression model (p-value < 0.00001), high coefficient of determination (R2 = 0.9886), and well-adjusted R2 value (0.9780) 18 , 59 .

A low but highly significant level of population differentiation was observed between the European-1 and -2 subclusters (F CT 0.018, P < 0.00001, Table 5 ); 59% of genetic distances between populations of the two subclusters were significant, but only 14% and 22% of the intracluster distances were significant.

So, even at ages 70–79, a 2SD higher apoB/apoA 1 ratio was associated with a highly significant ( P < 0.00001) relative risk of 3.13.

In both residue-level and protein-level assessments the improvement in performance of aaRNA over the alternative methods was highly significant ( P -values <10 −5 and <10 −10 , respectively).

As in the previous analysis the variable synchrony was highly significant [F(1,14) = 44.76, p = .00001], with stronger agreement after synchronous (7.10) than asynchronous training (2.99).

Results from AMOVA showed that while most of the genetic variance was partitioned within populations (89.8%), a significant proportion of the variance was partitioned among populations (10.2%) and gave a highly significant Φ ST value (0.102, P <0.00001).

Estimation of the SNP effect from the haplotype effect Under the hypothesis that one SNP of each haplotype was expected to have a major effect on the recorded trait, direct observation of those haplotype alleles that showed a highly significant effect (P < .00001) on one trait allowed to select one SNP where the two alleles showed opposite effects on that trait.

The similarity in prognostic group assignment was highly significant ( p <10 −5 by Chi-square test).

The strength of this dependence between the aCVT and aCrVT is demonstrated by highly significant p-values using a Fisher’s Exact Test of Independence (left p = 0.00001 and right p = 0.00018).

MSC-induced enhancement of AML cell proliferation in transwell cocultures was highly significant also when analyzing the overall results for this larger group of patients (Figure 2 A; p < 0.00001, Wilcoxon’s signed-rank test).

This search recovered the GCS2 HMM (based on PDB: 1r8g) as the highly significant best hit (p-value= 10 -5 ), with an alignment spanning the entire length of the GCS2 catalytic domain and matching all key conserved motifs (Fig. 2 ; see below).

A highly significant ( p ≤ 0.00001) reduction of E‐cadherin expression was observed in the order of HPV16+ < HPV18+ < HPV16+/18+ in both cell models.

The subjects’ own educational attainment showed a nominally significant negative association with F roh ( p = .045), while the contribution of parental education to offspring F roh was highly significant (father: p < 10 -5 ; mother: p = 9×10 -5 ), with more educated parents having offspring with fewer ROHs.

A correlation matrix was calculated for these genes, using Pearson Product-Moment Coefficient, defined as r x , y = ∑ i = 1 n ( x i − x ̄ ) ( y i − y ̄ ) ( n − 1 ) δ x δ y The values of Pearson correlations above 0.3 are statistically highly significant (p-value < 0.00001 after Bonferroni correction for multiple testing [ 85 ]).

Logistic regression testing the effect of sequence length on whether or not the query sequence have at least one BlastX hit ( E value 10 -5 ) was highly significant (p-value < 0.00001).

A test for subgroup differences revealed a highly significant difference between the SLT and DLT subgroups (Chi 2 = 749.98, p < 0.00001), further supporting the idea that the effects of thermal softening may differ based on tube type.

The analysis revealed a highly significant preference (Chi 2 = 47.145, p < 0.00001) towards conservative decisions (81.65%, n = 178) compared to invasive approaches (18.35%, n = 40).

The QIDS-SR scores after treatment were 2.2±2.3 (nondepressed range), and the difference from baseline was highly significant ( P <0.00001, Student’s t -test, one-tailed).

The differences are relatively constant across the subjects, and a paired student's t test returned a highly significant difference between the two conditions (P < 10 −5 ).

[ 32 ] led to highly significant heterogeneity ( p < 10 −5 and I 2 = 94 %); consequently we excluded this study from the meta-analysis.

SAD group had no difference in FVC improvement, but a highly significant difference for improved FEV 1 ( p < 0.00001) and improved FEF 25-75 ( p < 0.00001) in the SAD group. 5.

the time from diagnosis (in radically treated patients) until the first appearance of regional recurrences or distant spread, and overall patient survival (survival time until death from thyroid cancer) were compared across seasons. RESULTS Registry cases The 2627 thyroid cancer cases diagnosed in Norway during 1970-85 showed a highly significant time-effect when incidence was compared across 12 months (X2 = 119.3, P<0.00001) or four seasons (x2 = 35.6, P<0.00001), being highest during the last 3- month period October-December (Figure IA).

The pooled results demonstrated a robust and highly significant survival benefit in patients diagnosed under Sepsis-3 criteria (OR, 0.47; 95% CI, 0.39–0.57, P < 0.00001) ( Figure 6A ) and Sepsis-1/2 (OR, 0.61; 95% CI, 0.41–0.90, P = 0.0008) ( Figure 6C ).

The overall effect of surgery compared to sham surgery was highly significant (SMD 0.34, 95% CI 0.20 to 0.49; p<0.00001), while heterogeneity was large (I 2 =67%, p<0.00001).

The pooled MD was −20.25 (95% CI: −23.25 to −17.25), favoring obicetrapib, with a highly significant overall effect ( Z = 13.24, P < 0.00001).