“highly significant”

The pooled MD was −20.25 (95% CI: −23.25 to −17.25), favoring obicetrapib, with a highly significant overall effect ( Z = 13.24, P < 0.00001).

There was significant differences in adiponectin serum levels between treated groups and nontreated group (control), this difference was highly significant between omega-3 fatty acid and rosuvastatin plus omega-3 fatty acid ( P = 0.00001), whereas less significant between rosuvastatin and rosuvastatin plus omega-3 fatty acid-treated group and insignificant between rosuvastatin and omega-3 fatty acid-treated group [ Table 4 ].

Overall, across all 1,242 patients (MD = -0.83, 95% CI: -0.93 to -0.72), with a highly significant overall effects test ( P < 0.00001), there was significant heterogeneity among all studies ( I 2 = 84%) and among subgroups ( I 2 = 86.4%), as illustrated in Figure 5A .

The pairwise Pearson's correlations of SLB AUDPC BLUPs were highly significant between all pairs of environments, ranging from 0.62 to 0.95 with P < 0.00001 (Table 1 ).

Note that whereas adenomyosis was excluded from the meta-analysis and the effect size (OR) estimate and its corresponding 95% CI boundary were higher than 1.00, I 2 statistic was 96%, and Chi 2 test was highly significant ( P ≤ 0.00001).

The results were highly significant for all parameters (Wald χ 2 (1) < 10,000, p < 0.00001 in all cases).

This difference was highly significant (χ 2 = 30.12, P < 0.00001), with a RR of 7.14 (95% CI: 3.58–14.23), suggesting that tubing obstruction may significantly contribute to urinary stasis and infection.

3.2 Response to ETI therapy initiation Effects of ETI therapy assessed with averaged CFAbd-day2day © responses revealed a highly significant decrease in the median total score ( p = 0.00001).

Correlation analysis showed a highly significant linear positive relationship (R 2 = 0.466; p < 0.00001) of plasmatic B4GALTs with age from infancy to centenarians (Figure 1A ).

Concurrently, it establishes with highly significant evidence the definite advantage of aspirin in reducing the risk of minor bleeding (OR = 0.57, p < 0.00001).

To lend further support to the relationship between hepatic inflammation and TG levels in the liver, there were highly significant positive correlations between hepatic TG levels and TNFα (P < 0.00001), MCP1 (P = 0.0001), IL6 (P < 0.001) and IL1β (P < 0.00001) protein levels.

The overall effect test is highly significant, with a Z value of 4.69 ( P < .00001).

The production of potentially phased siRNAs alone is, however, not enough to class a locus as trans -acting so we concentrated on the 12 predicted highly significant loci with p values < 0.00001 and used the psRNATarget prediction tool [ 40 ] to identify potential targets for phased siRNAs (Table 2 , Additional File 6 ).

However, the improvements in sleep were highly significant in Group A in the 2 nd week of drug intake ( P = 0.00001) [ Table 3 ].

There was a strong relationship with sleep disturbance as indicated by highly significant correlations with all four SQS subscales (all p < 0.00001) but not with hours of sleep.

A three within-subjects RAnova (type of score × block × ear) showed a highly significant type of score effect, [ F (1.7,103) = 235, p < 0.00001, η p = 0.80, ω 2 = 0.22], with greater phonemes scores than word scores; block effect [ F (1,59) = 13, p < 0.00001, η p = 0.19, ω 2 = 0.022] with greater scores for the second block ( Figure 2A ), but no overall significant ear effect [ F (1,59) = 2.2, p = ns].

The regression model for PHA production was highly significant with p -values < 0.001%.

For example, if one gene is repressed by 1.8-fold, the statistical significance may not be very high, but if all 78 cRPGs are repressed to a similar degree with an average of 1.8-fold, 1.8-fold becomes highly significant (P-value < 0.00001 when compared to background genes).

A total of 259 highly significant ( P ≤ 1 × 10 –5 ) marker-trait associations (MTAs) were identified for seven phenotypic traits.

Indeed, four, highly significant (pairwise homoplasy index test, P < 0.00001) signals of recombination have been revealed at coordinates closely corresponding to the divergent regions.

The main factor Language was highly significant, F (1, 33) = 98.69, p < 0.00001, reflecting the overall better performance of Tashlhiyt than French participants.

After adjusting for sex, age, and race/ethnicity in Model I, the negative association remained highly significant (β = −0.038, 95% CI: −0.045 to −0.031, p < 0.00001).

The meta-analysis revealed substantial between-study variance (Tau2 = 684.19) and a highly significant Chi-squared test for heterogeneity (Chi2 = 330.07, p < 0.00001), indicating that the variation in effect estimates was predominantly attributable to differences among studies rather than sampling error.

the time from diagnosis (in radically treated patients) until the first appearance of regional recurrences or distant spread, and overall patient survival (survival time until death from thyroid cancer) were compared across seasons. RESULTS Registry cases The 2627 thyroid cancer cases diagnosed in Norway during 1970-85 showed a highly significant time-effect when incidence was compared across 12 months (X2 = 119.3, P<0.00001) or four seasons (x2 = 35.6, P<0.00001), being highest during the last 3- month period October-December (Figure IA).

The pooled HR remained highly significant (HR = 0.56, 95% CI 0.45–0.70; P < 0.00001) ( Supplementary Figure 1A ). 3.3.2.