“highly significant”

The forest plots reveal considerable heterogeneity among the included studies, as indicated by I 2 values of 99% and 98% and highly significant Chi 2 tests ( p < 0.00001).

In addition, disease duration correlated highly significant (p<0.00001) with the mean longitudinal FA changes in all tract systems.

In exploring the subgroup for tensile strength ( Table 4 ) there was a highly significant difference ( P < 0.00001) when nano filler was added to the material, however there was no significant difference when micro fillers were added ( P = 0.74). 3.1.2.

The excess of transition paths is highly significant by a binomial test ( P < 10 − 5 ; here and below, we do not distinguish values of P below 10 − 5 ).

However, the differences in mean distances within the groups were highly significant ( F = 128.13, P = 0.00001) [ Table 5 ].

There was no heterogeneity (I 2 = 0%), and the results were highly significant ( Z = 5.03, P < 0.00001). 3.5.5.

Hardy–Weinberg equilibrium analysis for rs2904880 revealed highly significant deviation from expected genotype counts ( χ 2 = 161.4, df = 1, p < 0.00001), characterized by a marked heterozygote deficit (observed 271 [22.66%] vs. expected 428.36 [35.82%]) and a reciprocal homozygote excess.

Localized rearrangements on a per-chromosome basis were identified using previously established metrics 19 : the presence of chromosomes that had a highly significant non-random distribution of breakpoints with a threshold of p < 10 −5 were considered to be clustered and chromosomes with high numbers of rearrangement events were identified as outliers defined as a breakpoint per megabase rate exceeding 1.5 times the length of the inter-quartile range from the seventy-fifth percentile for each sample with a minimum threshold of 35 breakpoints per chromosome.

Our results showed that divergence time estimates for the 47 backbone nodes between the RelTime and MCMCTree methods are very similar, and their correlation is highly significant (Pearson’s correlation coefficient r = 0.9907; P < 0.00001) (fig.

The terms for DNA-binding transcription activator activity (RNA polymerase II-specific) and actin binding were highly significant ( p = 1.0 × 10 −5 ), as was microtubule binding ( p = 2.0 × 10 −5 ).

This is also exhibited by mostly negative differences between the single-cell volumes 60 and 2 min after their exposure to sucrose-water solutions ( Figure 5C ), which lead to highly significant differences ( p < 10 –5 ) when compared with the results of the corresponding Leibovitz-water solutions.

We found a highly significant increase in the KEGG and REACTOME cell cycle pathway enrichment scores (both p < 0.00001), supporting the cell cycle phase analysis results (Fig. 4c ).

These changes correspond to a highly significant ( t (44) = 5.10, p < 0.00001) decrease in average FA in the white matter between left thalamus and left IPL (Figure 2B ).

graminis cultures were positively correlated with one another and very highly significant ( P = 0.00001) ( Table 2 ).

Interestingly, expression was limited to grade 2 and 3 DCIS with a highly significant interaction (p < 0.00001) between PPARγ and grade.

There was a strong positive association of Cp biomarker positivity and asthma severity category that was highly significant (P<0.00001).

norvegicus was highly significant (P-value <0.00001) by regression of shape onto centroid size for both dorsal and ventral views.

Our results show very highly significant correlation of concordance (Spearman's Ro = 1, p <= 10 -5 ) indicating no support for the premise that bowing had this effect.

Assessment of aCL Presence by Meta-Analysis Presence of aCL in dementia patients was highly significant compared to controls (OR: 4.94, 95% CI: 2.66–9.16, p < 0.00001; I 2 = 32%, p = 0.16) ( Figure 2 ). aCL was present in 32.80% of dementia patients and 9.50% in controls corresponding to 3.45 times higher probability to present with dementia than controls.

In a European patient cohort study of 110 candidate polymorphisms, Hhex SNP rs1111875, a major risk factor in T2D, was found to be a highly significant risk factor (p<0.00001) for AD, but only with the accompanying GSTM3 (rs7483) SNP ( 171 ).

Hypergeometric tests showed a highly significant overrepresentation of genes of the non-normalized modules in each normalized module (P<0.00001) consistent with similar networks being recovered by the two approaches.

Though the differences were small, particularly on the original task, they were highly significant (P < 10 −5 ).

All differences were statistically highly significant ( p < .00001).

However, the difference was relatively small, and when we eliminated the regions overlapping promoters the differences in the substitution rates estimated for neutrally evolving sequences and lncRNAs remained highly significant (Wilcoxon test, P -value < 10 −5 ).

Hence, undertaking multiple comparisons the overall global improvement with AOTG remains highly significant ( p < 0.00001), while each of the domains remain significant with two or one sided tests.