“highly significant”

Additionally, GCM1 showed highly significant enrichment for known autism susceptibility markers ( P = 5.49E-07; Fisher’s exact test) [ 46 ], and the expression levels of genes in this module were significantly higher during early brain development (Additional file 2 : Figure S4C).

However, the association between rs9465922 and IS remained highly significant after adjusting for self-reported diabetes status in our population (OR = 0.55, 95% = 0.44–0.70, P = 5.5 × 10 −7 ), suggesting the effect of this gene on IS may be independent of the effect of T2D.

Even with some inconsistencies between the results of SNP array analyses and those of real-time genomic-PCR analyses, the association between them was highly significant ( P = 5.58E-07 by Fisher’s exact test).

As an example, the analysis of 514 kidney clear cell carcinomas (KIRC) with the 23 transcripts comprising the Pyrimidine Biosynthesis Pathway generated two distinct t-SNE clusters containing nearly identical tumor numbers and associated with highly significant median survival differences (2090 days vs. > 4500 days, P = 5.6 × 10 − 7 , Fig. 1 a and b and ref.

Importantly, the sex differences in leptin and adiponectin ratios remained highly significant after further adjusting for BMI (leptin, P = 5.6 × 10 −7 ; adiponectin, P = 5.7 × 10 −8 ).

The model demonstrated strong risk stratification performance in the training set, with a highly significant difference between high- and low-risk groups ( p = 5.684 × 10 −7 ).

A highly significant genetic correlation was identified between the questionnaire-based hearing loss phenotype in the UK Biobank and phenotype HIGH (rG = 0.751, P = 5.75*10 −7 ).

The combined allelic test was highly significant, with p = 5.9 × e-7.

GWAS identified 10 highly significant SNPs for BC ( P = 5.96 × 10 –7 –1.04 × 10 –9 ) ( Supplemental Table 2 ).

Among 312 GO terms enriched with these genes, 22 were seed GO terms yielding a highly significant enrichment of seed GO terms ( p = 5.97e-7 ).

Furthermore, the CV-ANOVA p value is highly significant (p = 6 × 10 −7 ), indicating a good model.

Highly significant (median p-value = 6×10 –7 ) pair-wise differences in molecular marker expression were observed for all markers ranging from mature, functional, and synaptic neuron markers to astrocyte, oligodendrocyte, and microglial markers ( Figure 1B ; Figure 1—figure supplements 4 and 5 ; Supplementary file 5 ) – confirming neuronal and non-neuronal cell-type identities in the NeuN + and NeuN - nuclei samples, respectively.

The 52 targets with high cancer cytostatic scores contain 8 out of 24 known targets of the 14 FDA-approved metabolic anticancer drugs found in DrugBank ( Wishart et al, 2008 ) ( Supplementary Tables S1, S2 and S5 ), representing a highly significant enrichment (hypergeometric P -value <6 × 10 −7 ), testifying to predictive power of the model.

One month after the therapy shift (T3), we detected a highly significant decrease in the BRAF p.V600E and MEK1 p.P124L MAFs ( p = 0.0000006 and p = 0.0005, respectively).

Insulin response The changes in insulin concentration by time were highly significant (p=6×10 −7 ).

We also found that the CV-ANOVA p -value was highly significant ( p = 6 × 10 −7 ), which indicates a good model.

This stratification of patients by total poor prognostic events demonstrated highly significant associations with survival in both the Miller (p = 6e-7) and Pawitan (p = 4e-7) cohorts.

Categorization of subjects based on high systolic blood pressure (≥75th percentile) and low systolic blood pressure (≤25th percentile) generated a highly significant difference in slope of the principal component for CVD risk factors ( p = 6.0 × 10 −7 ), since individuals having high systolic blood pressure tended to have negative slopes (average = −0.37) while the group with low initial blood pressure did not show any change in slope (average = 0.01).

Because 6 HSPC populations were investigated, this finding was highly significant ( P = 6.106 × 10 −7 ; a binomial test).

Relationship Between Nociceptive Flexion Reflex Threshold, Fibromyalgia Syndrome Diagnosis, and rs4796604 Genotype The correlation between the rs4796604 genotype and NFR thresholds is highly significant ( r T = 0.23, p = 6.12E−07, Kendall’s Tau statistics).

Statistical analysis demonstrated a highly significant difference in methylation for all CpGs within top strand as compared to the reverse strand for CD45RA + CD15s − Treg ( p = 6.15E-07), but not for CD45RA − CD15s + Treg ( p = 0.026091).

From that initial value, the absolute decline is highly significant and similar for each subsequent cycle, in the range of 0.020–0.024 hour −1 ( P = 6.17 × 10 −7 , 9.74 × 10 −7 , 2.41 × 10 −5 for cycles 2, 3, and 4, respectively).

After removal of the data during the Covid pandemic, highly significant interactions were still detected between gender and mobility in first-time donations ( p = 6.2e-07) and between gender and age group in repeat donations ( p < 2.2e-16) ( Supplementary Table S3 ).

This effect was highly significant for both the ipsilaterally-tuned population ( t test, t (68) = 5.5, p = 6.2 × 10 −7 ) o and contralaterally-tuned population ( t test, t (162) = 7.15, p = 2.8 × 10 −11 ). p We found that attend in responses of contralateral neurons, but not ipsilateral neurons, were better described by a WTA model (a linear regression slope of 1 signifies a WTA response; Fig. 6 B ).

Overall, the relative fold-change between BRAF V600E and BRAF wt was about 10 and statistically highly significant ( p = 6.27 × 10 −7 ).