“highly significant”

There was a highly significant enrichment of methylation changes around GWAS single nucleotide polymorphisms ( P = 3.7 × 10 −7 ), notably the HLA region and MIR21 .

Expression heterogeneity of CD63 was found to be highly significant on this cell trajectory ( p -value = 3.755 × 10 −7 , Supplemental Table S3 ) and defined a green trajectory cluster ( Figure 6 D) comprising markers like cluster of differentiation 52 (CD52), heat shock protein family B (small) member 1 (HSPB1), Meis homeobox 1 (MEIS1), Pim-2 proto-oncogene, serine/threonine kinase (PIM2), RAD52 homolog, and DNA repair protein (RAD52) following CD63 expression ( Figure 6 E).

This difference is highly significant in both species (yeast: p = 3.8 × 10 −07 , human: p = 1.8 × 10 −21 , Wilcoxon one-sided test).

However, this association is highly significant ( p = 3.82E-07).

The waist circumference was higher per minor allele in never-smokers: +0.23% (95% CI 0.09% to 0.36%; p=0.0012), non-significantly related in former smokers −0.07% (95% CI −0.24% to 0.09%; p=0.37) and lower in current smokers −0.40% (95% CI −0.57 to −0.22 p=1.69×10 −5 ): differences among smoking groups were highly significant (p=3.85×10 −7 ; see online supplementary figure S2.

As expected from the relationship between plant times and theta sequences, there was a highly significant temporal modulation of MUA and plant times (5 rats, 61 epochs, 60–100 cm on w-track: t -test: P = 3.9 × 10 −7 ; Extended Data Fig. 4c ).

Combining the data from all cohorts (1232 patients and 5930 controls) resulted in a highly significant association between TAAD and duplications of 16p13.1 ( P = 3.97×10 −7 , OR = 12.6, 95% CI = 4.2–45.3).

O) as a fixed factor and the random factors of population and cage yielded a highly significant effect of selection regime on A ( p = 4×10 −7 ) and α ( p = 5×10 −9 ).

Discrepancy scores of normative data compared to sample data indicate a highly significant difference, where the LC sample has a greater score than the healthy population ( Z = 5.07, M COVID = 16.35, M norm = −0.63, p = 0.0000004; Figure 1C ).

Remarkably, we observed highly significant association between the methylation state at cg18181703 and the MetS status in our large cohort ( P = 4.01 × 10 −7 ) ( Table 3 ), suggesting the epigenetic status at this site of gene SOCS3 is strongly inversely associated with the presence of MetS.

The Rao & Scott-adjusted Pearson chi-square test indicated a highly significant effect of age on food purchases driven by security needs (food stocks), F [6.67; 7068.99] = 6.28, p = 4.04 × 10 −7 .

This effect of the random dot condition in the MSB ROI was highly significant (LMM with monkey subjects as random effects (Materials and Methods); p = 4.094e-07; Fig. 8 ).

catp-6(0) mutants present a highly significant smaller brood size when compared to N2 ( Table 1 , group c, ANOVA, Tukey post-hoc test, adj. p -value = 0.000000416).

In this, breed was found to be highly significant ( p = 4.2 × 10 -7 ), expression levels were significant ( p = 0.001), but behavioural trait ( p = 0.27) and interactions were not significant.

Signature performance was driven by the highly significant associations of the arginine/WARS ( p = 4.3 × 10 −7 , τ = 0.43), cortisol/SOCS1 ( p = 7.4 × 10 −6 , τ = 0.28) and 5-oxoproline/LAP3 (5.8 × 10 −5 , τ = 0.37) pairs ( Figure S8 ).

Figure 3 shows a highly significant association (log-rank P =4.33e −7 , Cox P =0.0040, HR 0.67, 95% CI 0.51, 0.88) between OS and methylation of MYLK3 , most prominently in totally debulked patients.

The difference between 7m (15%) and V6A (3.1%) is highly significant ( p = 4.5 × 10 −7 ; z = 5.0; ratio test), reinforcing the conclusion that the “home ground” for background-centric neurons is located in 7m/PGm, the genuine region of the precuneus.

In contrast, the 100-gene PDCD4 signature demonstrated highly significant prognostic value (HR = 0.63, 95% CI: 0.53–0.75, p = 4.5 × 10 −7 , C-index = 0.621; Supplementary Figure S3 ), with significantly superior discriminative ability (likelihood ratio test p < 2.2 × 10 −16 ).

An analysis of gene expression considering all genes and DGRP lines revealed a highly significant five-way interaction among injury, diet, age, gene, and line (ANOVA, F 144,2736 = 1.72, P = 4.58 × 10 −7 ), with interaction meaning that the effect of one factor on gene expression depends on the level(s) or one or more other factors.

The differences in FB-E miR-9 levels between the EtOH and control groups were highly significant ( p = 0.000000464825; Figure 6 A). *** p < 0.001.

Of note is that one of the DPA1∼DPB1 haplotypes (DPA1*01:03∼DPB1*04:01) is associated with protection and highly significant ( p = 4.76 × 10 −07 ).

Cross-correlations, in SDI_local, between the two populations were positive at all 22 chromosomes considered (range in r =0.05–0.999; median r =0.668; Supplementary Table 1 ). A sign test on all 22 correlations being positive is highly significant ( P =4.8 × 10 −7 , assuming a null expectation of a correlation being equally likely to be positive or negative).

Wilcoxon rank-test between TP datasets (Arabidopsis and non-Arabidopsis) were not observed to be significant while Wilcoxon rank test between non-Arabidopsis FN and TP datasets were observed to be highly significant (Wilcoxon rank test P = 4.8e-07 for Arabidopsis and for non-Arabidopsis datasets).

However, there was highly significant heterogeneity in the vitamin C effect between the trials with I 2 = 83% ( P = 4.8 × 10 −7 ).

Excluding rs864265, seven SNPs belonging to two different LD blocks showed highly significant associations with serum adiponectin (all P ≤ 4.8 × 10 −7 ).