“highly significant”

Both changes were highly significant (student’s t-test, p<2.3900e-8 for rHIgM22 vs isotype control; p = 0.0000 for PDGF/FGF-2 vs isotype control).

We demonstrate a highly significant association between the NR2F2 loss-of-function mutations and this syndromic form of DSD (p = 2.44 × 10 −8 ).

While variance in BMI differed significantly between PRS groups (Levene’s test p = 0.015), the PRS effect remained highly significant when accounting for heterogeneity (Welch’s ANOVA F = 21.0, p = 2.5 × 10 −8 ).

The average AUC improvement was statistically significant ( p -value = 2.1 × 10 −6 ), and the MCC comparison also showed a highly significant difference ( p -value = 2.5 × 10 −8 ).

Logistic regression analysis identified operative time as a highly significant independent predictor of flap loss ( p = 2.5 × 10 −8 ).

The frequency of APOE ε4 carriers increased progressively across the clinical spectrum, from CN individuals (25%) to those with MCI (53%) and AD (71%), with a highly significant group effect ( p = 2.5 × 10 −8 ). 3.1.

Fish that underwent Partial isolation (Pi), exhibited an intermediate, yet highly significant, change in social preference ( Figure 1A , right panel: C vs Pi, p=2.5e −8 , Mann-Whitney).

A highly significant interaction was seen between time and age (p = 2.6e-08).

Previous GWAS did not uncover an association between rs17810398 and age-related macular degeneration, but when analyses were stratified by sex, the association was highly significant for females ( p = 2.6 × 10 −8 ) and not males ( p = 0.382) [ 25 ].

Quantitative analysis evidenced a highly significant MEK5 6.2-fold increase (p=2.7×10 −8 ) and ERK5 5.5-fold increase (p=2.2×10 −9 ) in tumoral samples when compared to normal tissue ( figure 1j ).

5c ), and a paired t -test of the chromosome-level percentages was highly significant ( P = 2.722 × 10 −8 ).

The regression models reflect highly significant correlation values (Ras: R 2 = 0.78, P = 2.74E-08; RasGEF: R 2 = 0.35, P = 2.78E-03; RasGAP: R 2 = 0.38, P = 1.67E-03; RapGAP: R 2 = 0.38, P = 1.68E-03).

Comparing the full set of 1377 differentially expressed genes to those contained within the gene ontology term “central nervous system myelination” (accession number GO:0022010), we found highly significant enrichment of myelination-related genes (Fisher’s exact test, odds ratio = 3.66, p -value = 2.76×10 −8 ).

Strong and highly significant positive correlations were observed bilaterally between MMSE scores and GMV in the hippocampus (Right: R = 0.542, p = 2.83e-08; Left: R = 0.517, p = 1.59e-07), amygdala (Right: R = 0.48, p = 1.47e-06; Left: R = 0.403, p = 7.38e-05), and parahippocampal gyrus (Right: R = 0.45, p = 7.59e-06; Left: R = 0.407, p = 6.18e-05).

Patient-derived OPCs exhibited a size distribution that was strongly shifted toward smaller cells, a finding that was highly significant across all patient and control lines (Kolmogorov–Smirnov D = 0.25, P = 3.0 × 10 −8 ; Fig. 3d ).

MYO7A and PDZD7 were not only highly enriched, but the enrichment was highly significant statistically (p=3 × 10 –8 and p=2 × 10 –5 ).

The omnibus test of hazard across the quartiles of Lp-PLA 2 activity was highly significant ( p = 3 × 10 −8 ).

Such a difference would be highly significant for independent species (Kolmogorov–Smirnov test, p < 3 ∗ 10 -8 ).

The difference in the proportions of left and right flexions between the lumbar and cervical LHS groups was highly significant (Fisher’s Exact Test, two-tailed: p = 3 × 10 −8 ). 4.

In the sub-Saharan African sample, both the MAF and the DAF spectra showed a highly significant increase in the proportion of singletons with respect to the proportion expected under a constant population size model (χ 2 P = 3×10 −8 and χ 2 P = 9×10 −5 , respectively).

Analysis of variance indicated a highly significant genotype effect for both traits (p = 3.02 × 10 − 8 for LD; p = 2.04 × 10 − 4 for Survival%).

For the RNA-seq Diet, we again found a highly significant overlap with 52% of up-regulated genes in Suv420h dKO overlapping with PPAR-γ targets (odds ratio, 1.6; 95% CI, 1.37 to 1.93; Fisher P = 3.1 × 10 −8 ).

Here, we report a highly significant association with a variant (rs75652600, P = 3.12 × 10 −8 , odds ratios = 4.34) within a zinc finger gene, ZNF592 , from an imputation-based fine-mapping study of the chromosomal region 15q25 in African-Americans with neurosarcoidosis.

Statistical tests confirmed the highly significant differences in genetic diversity between subgroups Ia and Ib ( Z test p = 3.19 × 10 −8 ; T test p = 4.27 × 10 −8 ), and between phylogroups I and II ( Z test p = 1.64 × 10 −6 ; T test p = 1.04 × 10 −5 ).

This signal was driven by cases with and without extrarenal manifestations, since the burden difference was still highly significant when analyzing cases without extrarenal defects separately ( P = 3.21 × 10 −8 ; Figure 1A – B and Supplementary Figures 3 and 4 ).