“highly significant”

Exposure of cells to ox-LDL resulted in a moderate increase in enhancer histone signals flanking this CRE (Figure 6 A) and highly significant increases in both the chromatin accessibility of this CRE ( P =3.3×10 −8 ) and MITF expression (average log2FC=0.39; P <2.2×10 −16 ).

However, when father’s age and mother’s age were entered jointly in a multiple regression, father’s age remained highly significant ( P = 3.3×10 −8 ), but not mother’s age ( P = 0.49).

The results showed highly significant improvements for our method compared with both 3D morphological dilation ( P -value = 3.3882E—8) and 3D anisotropic distance transform ( P -value = 3.3882E—8).

In fingolimod-treated patients, the decrease in BAFF-R expression was highly significant in all evaluated B cell subsets (1.77 x 10 -5 ≤ P ≤ 3.42 x 10 -8 ) and most manifest in terms of effect size on transitional B cells ( Figures 2A–D ).

Time points 1 and 2 show a slightly increased level of additive genetic variation relative to later time points that is highly significant (Wilcoxon, p = 3.48×10 −8 ).

6 and 7 a highly significant, strong correlation (Spearman’s rho = 0.81, P < 3.5 × 10 −8 ) between the total number of stem cell divisions in an organ and the lifetime risk in that organ was reported.

The presence in ticks of Anaplasmataceae bacteria as a whole exhibited highly significant variations in relation to temperature ( P = 3.544e-08) and relative humidity ( P = 1.02e-06), being more abundant at higher temperatures and lower relative humidity, as typical during the summer season ( Supplementary Table S1 ).

The genetic contributions of LOF variants in our cohort with TAA remained highly significant when compared with the rates extracted from gnomAD (OR, 3.78 [95% CI, 2.35–6.06], P =3.6×10 −8 ), with no enrichment detected in individuals without TAA versus gnomAD (OR, 1.44 [95% CI, 0.86–2.40], P =0.16).

Here, we expect 70 genes and find 118- the actual number of genes in the overlap exceeds that expected by chance and was highly significant (p = 3.6 -8 , binomial test).

The expression difference between normal and tumor samples was highly significant ( P = 3.6 × 10 −8 ). 3 ́ RACE analyses confirmed the annotated 3 ́-end and revealed another, less abundant isoform with a non-annotated 3 ́-end (Figure 2C ).

1.12 × 10 6 CFU/mL, MW p = 8.60 × 10 −4 ) and in combination with lysozyme and lactoferrin decreased biofilm viability, and these results were highly significant (1.05 × 10 5 CFU/mL vs. 1.12 × 10 6 CFU/mL, MW p = 3.60 × 10 −8 ).

However, we found that EFEMP1 expression in GTEx human thyroid tissue was positively correlated with the risk alleles of one of the 2p16.1 BA-associated SNPs, and that this correlation was highly significant (rs1346786, GTEx eQTL P = 3.6 × 10 −8 ).

We found a highly significant correlation between the microarray and the RT-PCR gene expression quantification (Pearson correlation coefficients r = 0.89, P = 3.6e−8 and r = 0.65 P = 0.0009 for CTLA4 and TIMELESS , respectively) (Supplementary Figure 5 ).

The multiple comparison of normal mucosa versus CRC tumour tissue versus CRC cell lines resulted in highly significant p-values for all four ratios of circRNA/linRNA (circ0817/CUL5: p = 3.7e-08; circ3204/USP3: p = 6.4e-10; circ6229/METTL3: p = 2.2e-09; circ7374/TNS4: p = 1.7e-05).

Examining all 424 variants, there was a highly significant correlation (Spearman’s rank test) between the CD and IBD case/control replication p values ( p = 3.7 × 10 − 8 ) but not between CD and UC ( p = 0.234) or UC and IBD ( p = 0.094).

When excluding the patients with structural heart disease from the analysis, a highly significant association for AGXT2 rs16899974 was observed with any AF (P = 3.9 × 10 −8 ), and with paroxysmal AF (P = 3.0 × 10 −5 ) and chronic AF (P = 7.0 × 10 −4 ) separately.

As expected, T1 COGAVG was highly significant in all models ( p < 4.0 × 10 −8 ), although none of the models showed a significant effect of YEARS, age, sex, or disease course.

A comparison of the partially spliced transcripts identified by LRS to our nRNA-seq data showed a highly significant overlap between data sets ( P -value = 4 × 10 −8 , Fisher's exact test) ( Supplemental Fig.

The overall association between haplotypes and triglyceride levels was highly significant (p < 4 × 10 -8 ).

There was a strong and highly significant difference in copy number (estimated from the qRTPCR) among the groups identified by TaqMan and ddPCR (ANOVA: F 4,38 = 18.4, P = 4 × 10 −8 ) with a progressive increase from a single-copy average for susceptible homozygotes (Gn), suggesting that all or most are unduplicated, to resistant homozygotes (Sn) which averaged in excess of four gene copies (Fig. 6 ).

There was low between-study heterogeneity ( I 2 =32·8%: p =0·13), and the overall association of short sleep with diabetes risk was highly significant (OR=1·33 [95%CI: 1·20, 1·48); p =4x10 -8 ), with no evidence of publication bias (Egger’s test p =0·15).

Gene enrichment analysis was performed with the ToppGene Suite [ 27 ], and showed a highly significant enrichment (hypergeometric P = 4 × 10 -8 ) for 18 genes annotated to the set of 222 genes known to be up-regulated in CD133 + relative to CD133 - hematopoietic stem cells in the 'Jaatinen_HSC_Dn' Molecular Signatures Database (MSigDB) [ 28 ] entry.

Chi‐square analysis confirmed a highly significant difference among groups ( χ 2 (2, N = 42) = 59.19; p = 4.03 × 10 −8 ).

9 also confirms that genes from g4 and g6 are more representative of screening marker candidates: (the Binomial test for comparison of proportions (of marker candidates) yields highly significant p -values = 4.172×10 -8 , 7.59×10 -5 , for D1 and D2, respectively).

One of the significant signals for smoking status was from NCAM1 , index SNP rs7110863 (Wald test p = 1.6 × 10 −35 ), which was highly significant for smoking trajectory in the MVP (index SNP rs7126748; Wald test p = 4.2 × 10 −8 ).