“highly significant”

The LD score regression analyses revealed a strong and highly significant genetic correlation ( r g =0.83, s.e.=0.15, P =1.85 × 10 −8 ) between lifetime cannabis use and lifetime cigarette smoking (based on the Tobacco Alcohol and Genetics consortium 31 summary results), implying that SNPs for lifetime cannabis use and lifetime cigarette smoking are highly correlated.

A total of 248 predicted targets for all six proliferation-related miRNAs were mapped to the HCC DE genes, with a highly significant enrichment P -value ( P -value = 1.85 × 10 − 8 ).

We extended this method to allow for the fact that many of our families had multiple affected offspring (see supplementary methods ) and found that the imprinting-only model was preferred ( supplementary table 4 ); under that model, the imprinting effect was highly significant ( p = 1.85 × 10 −8 ) with the ratio of allelic effects for paternally to maternally inherited alleles equal to 0.75.

Kolmogorov–Smirnov test shows that the delay in developmental time for Ly4 in aged human subjects is highly significant ( p = 1.89 × 10 −8 ) [ 39 ].

In the present study, our much larger case number (4890 for ASD-related disorders) and the large number of missense mutations identified in TRIO (11 ASD cases, as compared to 1.07 cases expected for the same number of individuals in the general population) dramatically improved the statistics, leading to a highly significant whole genome association of TRIO with ASD-like syndromes ( P -value of < 1.96 × 10 −8 ; Supplementary Table 3 ).

A cluster of variants in ANO2 (encoding anoctamin 2, a calcium-activated chloride channel expressed on photoreceptor cells) on chromosome 12 reached the level of significance for loss of ≥5 letters after 1 year of treatment ( P < 5 × 10 –8 ), with the ANO2 rs2110166 SNP demonstrating highly significant association ( P = 1.99 × 10 –8 ).

In the adjusted model, a highly significant association between PRS and severe COVID-19 was found: OR = 1.54 per standard deviation (95% CI: 1.3–1.8 with p -value = 2e-08, Supplementary Table 8 ).

Single-marker and pairwise interaction analysis using LR Single-marker analysis showed highly significant disease association with rs2476601 ( p = 2 × 10 -8 ), and nominally significant effects for rs237025 ( p = 0.003) and CT60 ( p = 0.038) in both the median-replaced and the imputed data sets (see Figure 2a and 2c ).

abortus S99 sLPS) was tested and shown to be highly significant ( p = 0.00000002).

8b , right), where the slope of the fit decreases by more than half in the resting as compared to the running state across all combinations of N t and L , yielding a highly significant difference (two-tailed, paired t -test; p = 2e − 8, t = 9.2, df = 19).

Calculating the best-fit linear regressions for the ON and OFF populations (gray and black lines, respectively) revealed a highly significant positive correlation in both populations (ON: p = 2 × 10-8; OFF: p = 5 × 10-6), suggesting that the size of the dendritic field scales with the size of the soma.

After excluding the outlier, the assumptions were met, and a much stronger and highly significant correlation was observed ( R = 0.91, p = 2 × 10−8).

The probability of obtaining male versus female pups from fl/fl-Cre or wt/fl-Cre females was highly significant (P<2 × 10 −8 ).

The AVIRIS data model had a very high coefficient of determination ( R 2 = 0.98) and was highly significant (α = 0.05, p = 2 × 10 −8 ).

Sixty-eight genes had a direct association through co-occurrence, which is a highly significant over-representation ( p = 2.04 × 10 -8 ) given the number of genes associated with this concept in the predefined concept set "Genes".

The linear relationship remained highly significant even after removing any combination of one ( p < 2.10 × 10 −8 ) or two neurons ( p < 3.34 × 10 −5 ), indicating that the observed effect was not driven by a small subset of cells.

Interestingly, this correlation remains highly significant (R = 0.98 & p = 2.1 × 10 −8 ), when considering data from the United States (i.e., 44,488 taxa in 24,930,000 km 2 from 2,200,000 records; [ 8 ]).

Regression analysis (see Methods) showed that this association is highly significant (Fig. 3f , p = 2.1e−08, R 2 = 0.51, n = 30).

The effect of INH + STR resistance on THD in L2.2.1 isolates was also highly significant when incorporating multidimensional scaling (MDS) components as covariates in linear regression ( P = 2.14 × 10 −8 ), suggesting that substructure within the L2.2.1 sublineage was not driving the association.

One marker (rs885036, position 98671226) on chromosome 2q12 showed a highly significant interaction with treatment arm (P = 2.17x10 -8 ).

When an interactive linear model was again considered, the result was also highly significant both for the high-status group (β-estimate = −37.4445, t = −5.60, p = 2.18 × 10 −8 ; model Adj.

We found a highly significant tendency between different tumor tissue types (one-way ANOVA, P =2.20×10 −8 , FDR=8.95×10 −7 ) ( Table 5 ).

We observed a highly significant difference in Wolbachia density between species at the female (W = 11, P = 2.21 × 10−8), L1 (W = 30, P = 4.07 × 10−7), L2 (t = −9.54, P = 5.19 × 10−11), L3 (W = 18, P = 2.01 × 10−7), and L4 (t = −3.35, P = 0.0017) stages, with Cx. quinquefasciatus consistently showing higher densities than Cx. pipiens molestus .

We found some correlation between the contig N50 values and the number of NUMT regions (Spearman’s correlation, ρ = 0.60, p = 0.002) and a highly significant correlation between the contig N50 and the number of NUMT sequences, as well as the total size of NUMT sequences (Spearman’s correlations: ρ = 0.88, p = 2.3E−8; and ρ = 0.9, p = 5.47E−9, respectively).

These increases are highly significant, having scores of χ 2 = 16.72 ( p = 2.3E -8 ) and χ 2 = 72.5 ( p = 1.6E -17 ) to S. nigrimanum and S. vittatum , respectively.