“highly significant”

There was a highly significant positive relationship between tissue 13 C and 15 N for pitchers harvested 3-h after receiving U-Phe at both Fort Albany ( P = 1.28×10 −8 ; Fig. 3C ) and Tom Swamp ( P = 7.17×10 −8 ; Fig. 3D ).

5 e), TMB values also increased with the progression of the stage, with highly significant differences in TMB between T2 and T4 ( p = 1.3e−08) and between T1 and T4 ( p = 0.0001).

For NEUROD1 , both promoter and gene body methylation give a highly significant prediction (p value = 1.3e-08) ( Figure 5 , upper left).

Accordingly, we found highly significant interactions between temperature and sex ( χ 2 = 36.4, p = 1.3e‐08).

Integrating genome-wide association study of 47 F 2 roosters with population resequencing ( n = 50), we identified a highly significant locus on chromosome 33 ( P = 1.35E−8) harboring PMEL as the sole credible candidate.

A Wilcoxon test of higher expression of the “little” exon in those over 10 years old across all brain regions was highly significant ( p -value = 1.386e−08).

If we solely consider the overlap amongst the eight brain studies, there is relatively low, but highly significant, levels of replication (p = 1.4e −8 ).

For this list of 1409 DETs unique to the ASD GI ileal biopsies, the Diseases and Disorders category returned highly significant associations with: (1) gastrointestinal disease [217 genes; p = 1.4×10 −08 ] including inflammatory bowel disease [42 genes; p = 3.2×10 −05 ] and colitis [25 genes; p = 8,8×10 −04 ] and (2) inflammatory response [198 genes; p = 3.8×10 −07 ] including inflammation of organ [88 genes; p = 3.8×10 −7 ], antibody response [27 genes; p = 2.1×10 −6 ] and activation of leukocytes [74 genes; p = 4.9×10 −6 ].

Beloniformes Based on independent contrasts, the relationship between the number of abdominal vertebrae and log FR is highly significant (r = 0.61, P = 1.42 × 10 -8 ; df = 66; Figure 7 a); that between the number of caudal vertebrae and FR is also significant but the correlation is not as strong (r = 0.4, P = 3.30 × 10 -4 ; df = 66), and that between the number of abdominal and caudal vertebrae is also significant and positive (r = 0.57, P = 2.33 × 10 -7 ; df = 66; Figure 7 b).

The statistical analysis of antioxidant capacity confirmed significant differences among the tested materials, with ANOVA results ( Table S5, Supplementary Materials ) indicating a highly significant effect (F = 73.01071, p = 1.46 × 10 −8 ).

Compared to the dfmr1 mutants, the Trhn overexpression results in a highly significant elevation of serotonin in the MB ( UH1 -Gal4 driven Trhn overexpression; p = 1.477 × 10 –8 ), with a similar elevation from the other drivers (Fig. 2 D, right).

Pantoprazole induced highly significant suppression across all genes at both 50 μg/mL and 100 μg/mL, with comparable p-values (p = 1.49 × 10 -8 ; BH-adjusted p = 1.49 × 10 -8 ), highlighting a consistent and substantial inhibitory action ( Figure 17a ).

It was not part of any batch effect, it was detected by three methods, there was a statistically highly significant level of agreement between 16S amplicon sequencing and both metagenomics ( P= 1.5 x 10 -8 ) and a targeted PCR/qPCR assay ( P =9.7 x 10 -21 ), none of 47 negative controls analysed by 16S sequencing were positive for S. agalactiae, and there was no association with mode of delivery ( Extended Data Fig. 7 ).

The association of decreased FGF13 expression with POAF was highly significant ( P =1.52x10 −8 , FDR=0.0001) after controlling for age, sex, and corrected QT.

Similarly, the same four variables were also highly significant independent predictors of eGFR decline (defined as 50% reduction from the baseline eGFR) in our cohort (Model 2): baseline eGFR [HR = 0.98, 95% CI 0.98–0.99, p = 1.6*10 −8 ], serum albumin [HR = 0.46, 95% CI 0.35–0.62, p = 2.7*10 −7 ], hemoglobin [HR = 0.81, 95% CI 0.75–0.89, p = 1.5*10 −6 ], and SBP [HR = 1.02, 95% CI 1.00–1.03, p = 6.4*10 −3 ].

pneumoniae stimulation, showed a highly significant association in males ( p = 1.6 × 10 −8 ), but not in females ( p = 0.859), nor in the joint analysis ( p = 0.0002), suggesting a male-specific effect.

Gene-based analysis supported the involvement of TRAF2 , MAP2K4 , and MAP3K5 as mediating complications risk and a highly significant trend was identified between the number of risk genotypes and complications risk (P = 1.63 × 10 −8 ).

However, a meta-analysis using a modified random effects model showed more highly significant P values: P = 1.66 × 10 -8 at rs34391416 ( EFCAB4A ), P = 7.56 × 10 -9 at rs147862429 ( CHID1 ), and P = 1.11 × 10 -8 at rs143705409 ( AP2A2 ).

The direction of this enrichment is highly significant ( P = 1.662 × 10 –8 , one-tailed exact binomial test).

However, alpha diversity across subjects (intersubject) was highly significant ( P = 1.68 × 10 –8 ).

Among the anticancer pathways, the pathways in cancer had the highest enrichment score (7.754) and a highly significant association ( p = 1.7e-8), emphasizing its pivotal role in cancer-related mechanisms.

The BP GO term “response to toxic substance” was highly significant too (16 genes among the top 65; P-value = 1.72e-08), followed close by the more general term “cellular response to chemical stimulus” to which half the genes were related (40 genes of top 88; P-value = 1.41e-07).

The mean granule diameter under MES was 0.018 μm (±0.014 μm), compared with 0.073 μm (±0.043 μm) in the control, corresponding to a 4.0‐fold difference that was highly significant (Welch's t ‐test, p = 1.75 × 10 −8 ).

Spearman correlations indicated that U2AF65 expression correlated significantly with EMSA H3 values, and that the correlation was highly significant in tumor extracts (cytoplasmic p = 1.8e-8; nuclear p = 5.9e-5; total p = 1.8e-8; Table 3 a, Additional file 4 ).

The p -value of the SNP associated with E1 was highly significant in the two collections: p = 1.83E-08 in the core collection and p = 1.21E-11 in the total collection.