“highly significant”

This enrichment is highly significant ( p = 1 × 10 −8 ), especially when considering that all miRNAs may not necessarily disrupt transcript levels.

A burden test adjusted for sex and the first five principal components for the 15 loci revealed highly significant enrichment in rare homozygous, potential compound heterozygous, or hemizygous variants in patients relative to controls (P = 1 × 10 −8 ; odds ratio = 26.6; 95% confidence interval = 7.3–96.6), with 12 carriers among the patients (10.7%, including four homozygotes, one potential compound heterozygote, and seven hemizygotes) vs. three (0.25%, two homozygotes, one hemizygote) among the controls.

We recovered the PCDH15 locus as a highly significant sweep region consisting of more than 300 variants spanning 369.5 kb ( p -value < 10 –8 ), indicating a strong signature of selective sweep.

All bleaching groups exhibited a highly significant and greater whitening difference compared to the control group (data not shown; p < 0.00000001, as determined by Dunnett's post hoc test).

Paired statistical tests across all datasets indicate that these improvements are highly significant ( p < 1 × 10 −8 ).

This enrichment is highly significant, as only 5.5% of informative sites overlap a DSB hotspot (p < 10 −8 , calculated from 10 8 permutations; see ‘Materials and methods’—‘Inclusion criteria’).

In terms of number of targets predicted, there was highly significant difference between conserved and soybean-specific miRNA families (Student’s T-test, P < 10 -8 ).

Moreover, the correlation between ensemble mean forecasts of SST EEIO and their error is highly significant (r = 0.77, p < 10 − 8 ), i.e. small real multi-annual variations in the state of the IOD are vastly exaggerated by the hindcasts and indicate state-dependence of SEAS5 forecast errors in the EEIO.

These genes were chosen on the basis of showing highly significant self-linkage ( p < 10 −8 ) and at least a 1.2-fold difference in expression between segregants bearing the BY and RM alleles, such that no false positives and only one chance trans linkage due to a nearby gene were expected (see Materials and Methods ).

This difference is significant for six of the 12 genes ( p <0.05), and highly significant when all 12 genes are pooled ( p <10 −8 ; Table 3 ).

These measurements, distinguishing biopsy-positive from biopsy-negative men, were highly significant ( P < 10 −8 ; 100% sensitivity and 81.8% specificity).

We listed highly significant genetic effects of loci (−Log 10 P >8.0 and >1.0%, >0.5%) and consistent loci with environment interaction which were stable in a particular ecological area across at least two years for lint yield and three yield traits ( Figure 1 , Table 2 – 5 ).

The difference is highly significant across repeated experiments with different set of random inputs ( p < 10 −8 , n = 10, paired t -test).

Biological underpinning of the shared genetic components—translational evidence from mice For each of the Master PCs, the top-500 correlations across all records of the Amygdala Cohort Database, ranked by the Genetic Correlation (Spearman's rho), were strong (absolute value ranging from 0.7 to 0.9), and highly significant ( p < 10 −8 , Supplementary Tables 5, 6 ).

These genes were either associated with resistance to both lead and cadmium in both sexes or had highly significant ( P < 10 −8 ) effects in any one condition.

In contrast, HGP treatment induced a highly significant increase in WISP2 expression ( P < 10 −8 ) [ 40 ], but reduced IMF deposition [ 17 ], the opposite of what would be predicted based on the analysis of expression of WISP2 and the IMF 5 gene set genes in WxH and PxH genotype animals.

When we assessed the relationship between these two major allele classes and the above-described symptomatic and asymptomatic disease outcomes, we found a highly significant ( P < 1e −08 ; analysis of variance [ANOVA], F 2,43 = 30.06) relationship between allele class and disease outcome such that those CC-RIX mice homozygous for the classic inbred allele showed an enhanced propensity for symptomatic disease outcomes.

The analysis demonstrated a highly significant result (test statistic = 0.0, p < 0.00000001), indicating that median stent migration was greater than zero and that measurable displacement occurred between the three-month and one-year intervals.

Both the integrated fluorescence intensities, which represent the amount of DNA per nucleoid ( Figures 3B,D and Table 1 , columns 11 and 12), and the measurements of nucleoid lengths ( Table 1 , columns 13 and 14) indicate that the difference in DNA between small and large deeply-constricted cells at the fast growth rate is highly significant ( p < 10 -8 , as determined by a two-tail t -test); at the slow growth rate, the difference remains significant, but just barely ( p = 0.035).

All of these predictors gave highly significant ( P < 10 -8 ) improvements over random pairs.

All enrichments for GO ontologies representing these six biological processes were highly significant; P <10 −8 .

In cross 2, in which the EJ1 chromosome was present and the HR-h pathway was available, we saw highly significant decreases in HR-h repair in brca2 mutants ( P <1e −8 ) ( Figure 1 B).

This test also shows that the difference between AI and human text is highly significant (− log 10 (p)≈8, p ≈ 3.69 × 10−9), and it is due to AI text often having less variety in its vocabulary.

Indeed, Pearson correlation between E2F1 and CCND1 is close to 0 and not statistically significant ( P = 0.4) while the MI is highly significant ( P = 10 − 8 ).

Cellular RNAs that increased in concentration slowly and steadily throughout most of the observed infectious cycle, which are grouped in cluster 5, exhibited a highly significant enrichment in RNAs specifying proteins that participate in the establishment and maintenance of chromatin structure ( P = 10 -8 ).