“highly significant”

1 B, were 0.45 ± 0.13 (standard deviation) and 0.92 ± 0.07, respectively; the difference was highly significant (P < 10 −10 , t test for paired measurements).

In an ANOVA with gain treated as a continuous regressor, the group effect for channels was highly significant (middle, p < 10 −10 ); lines connect channels that are not significantly different in post-hoc tests at level α =.05.

The overall statistic is highly significant ( p < 10 −10 ) for the first three eigenvectors but insignificant for the fourth ( p = 0.97), indicating that this eigenvector is capturing population subdivision that is different from the traditional western/central/eastern/bonobo designations.

The darkred gene module had a highly significant correlation between GS and MM with respect to both CVH metrics ( r = 0.39, p -value = 1.0 × 10 −10 ) and BDI-II score ( r = 0.62, p -value = 1.4 × 10 −28 ) ( Figure 3 ). 3.5.

All quantiles yielded highly significant P -values ( P < 10 −10 ), confirming that the inclusion of the frame force significantly improves model performance.

Despite the small size of the validation set (412 d ( P , T ) and 694 d ( P , P ) interactions), representing only 1% of the possible secondary regulatory interactions, PhosTF predicted 40% of the known d ( P , T ) and 28% of known d ( P , P ) interactions, which was highly significant ( p < 10 −10 ) when compared to the rate of predictions overall (20% and 18% respectively).

Across multiple Glomeromycetes species, chi-square tests of double-base substitution bias gave highly significant P value (all p < 10 − 10 ), and TT>AA, TA>AT, and AT>TA repeatedly showed the strongest positive standardized residuals within the TT, TA, and AT categories, respectively ( Supplementary Tables S4 , available as supplementary material at Bioinformatics Advances online; Supplementary Methods , secti

We computed estimated axon conduction velocities from diameters of myelinated and unmyelinated fibers 28 along the proximal to distal axis and observed a strong and highly significant correlation (Fig. 2g , r 2 = 0.83, p < 10 − 10 ).

3a ), with the logarithm of exogenous cAMP concentration a highly significant predictor of average capsule thickness ( P < 10 −10 ).

We found that observation interval was a highly significant factor ( p < 10 −10 ), whereas the effect of the ensemble size was near significance ( p = 0.0758) because of the difference in RMSD error area between k = 5 ensemble member trials and other ensemble sizes.

Eighteen of the highly significant ( p ‐value > 10 −10 ) associations were not near any a priori candidate genes.

This revealed four regions with highly significant differentiation ( P < 10 −10 after Bonferroni correction, per SNP χ 2 test (d.f. = 1); Supplementary Fig. 1 ).

This difference was statistically highly significant ( p < 10 −10 ).

Due to the small-effect of the locus on milk production traits, the analysis of production data used a multi-trait meta-analysis [ 11 ] strategy while a standard association test was conducted for milk phosphorus concentration. Peak significance for phosphorus concentration was observed for two variants mapping to intron 2 of the SLC37A1 gene (rs109254133 and rs208161466; P < 1 × 10 −10 ), both of which were also highly significant in the multi-trait meta-analysis ( P < 1 × 10 −10 ) and in complete LD in the sequenced animals (Additional file 1 : Table S2).

With weak ( m = 10 − 8 ) or strong introgression ( m = 10 − 7 ), on the other hand, the D -statistic was in the ranges of 0.04–0.31 and 0.33–0.73, respectively, and in all cases highly significant ( P < 10 − 10 ) ( Fig. 2b,c ).

Notably, GO analysis of the 708 up-regulated genes did not show significant enrichment in any specific GO category, but the 733 down-regulated genes showed highly significant enrichment in several categories, with the top three (Benjamini adjusted P -value < 1 ×10 −10 ) classified as neural lineage related categories, including ‘neuron differentiation’, ‘transmission of nerve impulse’ and ‘neuron development’ (Figure 1D ).

Several proteins were upregulated in the CBD-treated group, including large ribosomal subunit proteins (uL30/Rpl7, uL1/Rpl10a, uL2/Rpl8), molecular chaperones (Hsp90b1, Hspe1, Hspd1), calumenin (Calu), and macrophage migration inhibitory factor (Mif), all with highly significant changes (p < 10 −10 , FDR <10 −9 ).

First, we found that the relationship between mean gene expression and CAI was highly significant and positive, as expected (adjusted R 2 = 0.27 , P < 10 − 10 , fig. 5 A and B ).

Finally, we also fitted a linear model that included the interaction between the mother and father genotypes with temperature and found that this interaction was highly significant (LRT: χ 2 = 303.9, df = 8, P < 1 × 10 −10 ).

The correlations between the average integrated NEX and average integrated NINH for all cortical locations in all animals and all 4 conditions of moving bars ( n = 32) were all highly significant (F-statistics p < 10 −10 ).

However, gene ontology enrichment analysis revealed a highly significant enrichment of glycolysis-associated proteins ( P < 10 10 ), with downregulation of the entire glycolytic pathway, and conversely an upregulation of AMP-activated protein kinase signaling– and autophagy-associated proteins, promoting catabolic pathways to generate more ATP.

5C ), and this difference was highly significant within an animal across within-sequence repetitions (Fig. 5D , p < 10 −10 , Wilcoxon Rank Sum test, n 1 = 162, n 2 = 1428) and across animals (Fig. 5E , p = 0.0079, Wilcoxon Rank Sum test, n = 5), as well as in single cells recorded in the ORR in 2p in the same animals (Fig. 5F , p < 10 −100 , Wilcoxon Rank Sum test, n = 765).

These associations were highly significant ( p < 1 × 10 −10 , q < 1 × 10 −10 ).

At the gene level the overlap in repressed genes was highly significant ( p < 1x10 −10 ), consonantly when top repressed genes in T47D cells were evaluated the majority of them were repressed greater than 1.5-fold (Figure 4C ).

Matrix‐like voxels continued to show higher movement‐related activation than striosome‐like voxels across all body parts (left foot, left hand, right foot, right hand, tongue), with highly significant differences in every condition (all p < 10 −10 ).