“highly significant”

Although the differences between 10 (jMOSAiCS specific) and unenriched regions did not appear as pronounced as the differences between 11 (enriched according to both methods) versus 00 (unenriched according to both methods), the observed differences were highly significant ( P values < 1 × e -10 with both the t-test and Wilcoxon rank-sum test), indicating that these regions are enriched for H4K3me3.

We observed highly significant differences in ventral gill raker number and spacing between marine LITC and freshwater FTC fish for both wild and lab-reared fish ( P <10 -10 ) for each comparison by Tukey’s HSD test; Figure 1 C, D, Additional file 4 : Figure S3).

To further explore this relationship, we preformed a linear regression for Tup1 binding by the number of recruiter proteins bound and discovered a highly significant regression of R 2 = 0.500 (P<1×10 −10 ) ( Figure 2D ) .

In this regard, the change in CD66b expression by bound cells was highly significant, p < 10 –10 and P < 10 –5 compared to BSL and CIRC respectively (Fig. 3 c).

First, we found that the relationship between mean gene expression and CAI was highly significant and positive, as expected (adjusted R 2 = 0.27 , P < 10 − 10 , fig. 5 A and B ).

As most tested associations were highly significant ( p < 10 − 10 ), precise p-values are reported only for those with p > 10 − 10 .

This revealed a moderate, but highly significant, correlation between responses to the two interventions in RCC4 cells (Pearson’s r = 0.33, P < 1 × 10 −10 , Fig. 3d left panel).

We found 1060 upregulated genes in Wit49 and 396 in 17.94, with a highly significant overlap of 212 genes between the two cell-lines ( p < 10 −10 ) ( Figure 3 A).

These associations were highly significant ( p < 1 × 10 −10 , q < 1 × 10 −10 ).

The downregulated modules include 170 genes ( p < 1e-06), among them 13 highly significant genes ( p < 1e-10): COL10A1 , SAMD9 , PLPP4 , COMP , POSTN , IGHV4–31 , THBS2 , MMP9 , FNDC1 , HOPX , TMEM200A , INHBA , and SULF1 .

Finally, we also fitted a linear model that included the interaction between the mother and father genotypes with temperature and found that this interaction was highly significant (LRT: χ 2 = 303.9, df = 8, P < 1 × 10 −10 ).

5C ), and this difference was highly significant within an animal across within-sequence repetitions (Fig. 5D , p < 10 −10 , Wilcoxon Rank Sum test, n 1 = 162, n 2 = 1428) and across animals (Fig. 5E , p = 0.0079, Wilcoxon Rank Sum test, n = 5), as well as in single cells recorded in the ORR in 2p in the same animals (Fig. 5F , p < 10 −100 , Wilcoxon Rank Sum test, n = 765).

Though a highly significant ( p < 10 −10 ) correlation between place field distance and cross-correlogram (CCG) latency was identified at the θ time scale ( S13A Fig ) with ρ = 0.30, the fraction of variance explained (R 2 = 0.07) was very low compared to the behavioral time scale correlation ( S13B Fig ) with ρ = 0.68 and R 2 = 0.46.

Relatively large and highly significant interaction effects were found in the gradients of WF ( β PD = 0.46, 95% CI = [0.33, 0.59], P < 10 −10 ) and R2* ( β PD = -0.47, 95% CI = [−0.63, -0.32], P < 10 −7 ).

At least one error affecting a whole chromosome was detected for total of 15,842 (62.1%) of the remaining 25,497 blastomeres as compared to 7,623 (44.3%) of 17,219 TE biopsies, a highly significant difference [ χ 2 (1, N = 42,716) = 1323.8, P < 1 × 10 −10 ].

Gene expression profiles of the mammary tumors for MMTV-cyclin D1 KE and MMTV-cyclin D1 WT mice showed highly significant overlap ( p < 1 × 10 −10 ) ( Supplementary Figure S9A–S9C and Dataset S2).

When intermittent shedders are compared to continuous shedders, using the G-rho family of Harrington and Fleming, a highly significant difference between the survival of intermittent and continuous shedders is obtained ( p < 1.e-10).

Moreover, assessing, collectively, only those ( H +)-carrying CEHs that had a single representation in the WTCCC, the disease association is still highly significant and of similar magnitude to other ( H +)-carrying CEHs (i.e., OR = 3.0; CI = 2.7 − 3.4; p < 10 −10 ).

This difference in population frequencies between the African and European populations was highly significant ( p < 1 × 10 −10 ).

All quantiles yielded highly significant P -values ( P < 10 −10 ), confirming that the inclusion of the frame force significantly improves model performance.

When plotting the solubility and disorder scores at neutral pH (pH = 7.0), a highly significant linear correlation was observed between these two variables (R 2 = 0.90, p < 1 −10 ) ( Figure 3 ), suggesting that solubility and disorder are intimately ligated in this dataset.

1 B, were 0.45 ± 0.13 (standard deviation) and 0.92 ± 0.07, respectively; the difference was highly significant (P < 10 −10 , t test for paired measurements).

5 , 6 , p < 0.05, false discovery rate (FDR) corrected], and in nine such comparisons, results were highly significant (Figs. 5 , 6 , p < 10 −10 , FDR corrected); see Supplementary Data 5 for AUC histogram bin data (bootstrapped resamples).

Genes containing highly significant Circ-SNPs with a more stringent p -value cutoff ( p -value ≤ 10 −10 ) are highlighted.

This difference is highly significant statistically (P < 1.0E-10, Chi-square test).