“highly significant”

We found 1060 upregulated genes in Wit49 and 396 in 17.94, with a highly significant overlap of 212 genes between the two cell-lines ( p < 10 −10 ) ( Figure 3 A).

Though a highly significant ( p < 10 −10 ) correlation between place field distance and cross-correlogram (CCG) latency was identified at the θ time scale ( S13A Fig ) with ρ = 0.30, the fraction of variance explained (R 2 = 0.07) was very low compared to the behavioral time scale correlation ( S13B Fig ) with ρ = 0.68 and R 2 = 0.46.

The difference in the number of apoptotic cells between active and inactive testes of this species was highly significant (active: 5.2 ± 10.7 cells/0.5 mm 2 ; inactive: 169.9 ± 38.4 cells/0.5 mm 2 ; Wilcox test, p = 1.03 × 10 −10 ; Figure 5 E).

Nevertheless, a highly significant, positive correlation, was found between the qPCR and RNA-seq analyses (r = 0.91, P = 1.07 × 10 −10 ; Fig. 5e ), which supported an overall concordance between the results of the two techniques despite the low replicate number for RNA-seq analysis.

Results Case-control comparisons showed highly significant mean group differences for accuracy ( p = 1.1 × 10 − 10 ), with an effect size (Cohen’s d = 1.6), more than twice as large as the mean effect size reported in a previous meta-analysis (Uljarevic and Hamilton, 2012, J Autism Dev Disord ).

Consistent with these observations, gene signature–based deconvolution of cell types by xCell ( 24 ) showed highly significant enrichment of immature dendritic cell (iDC) signatures in the normal nasopharynx compared with epithelium from other upper airway sites including the tonsil ( P = 1.11 × 10 −10 ; fig.

Although heterogeneity of response was observed in different cells, the finding that 10 significant cells out of 18 at p < 0.05 was highly significant at the population level (binomial test; p = 1.12E−10; n = 18 recordings from 7 animals).

Analysis of a deposited EWS dataset generated by Savola and co‐workers 48 using the SurvExpress tool 49 showed highly significant separation (hazard ratio 8.99; P = 1.128 × 10 −10 ) of the overall survival of EWS patients into low‐ and high‐risk groups based on the expression of PHGDH , PSPH , PSAT1 , SHMT2 , SLC1A5 , MTHFD2 , and MTHFD1L (Figure 7 G).

The difference between Shift 2 and Shift 3 was also highly significant (mean difference = 4.67, p = 1.13e-10) (Table 5 ).

Furthermore, highly significant enrichments in biological functions have been observed to be related to the immune system; for example, Inflammatory Response (p<1.15E10 −16 –2.06E10 −4 ), Immunological Disease (p<1.11E10 −11 –1.98E10 −4 ), Hematopoiesis (p<7.52E10 −28 –2.91E10 −4 ) and Cell-mediated Immune Response (p<5.87E10 −27 –2.62E10 −4 ) were frequently encountered.

The main effect for the participant group was highly significant (F(1, 332.00) = 44.29 and P = 1.17 × 10 −10 ).

17 Although the computed P -value from this ES is highly significant ( P = 1.18 × 10 −10 ), such a mean increase in blood pressure may not always have clinical implications.

Both main effects were highly significant: experiment type, F (4, 7079) = 13.13, p = 1.18 × 10 −10 , η 2 = 0.0067, and erosion method, F (5, 7079) = 95.04, p = 3.37 × 10 −97 , η 2 = 0.0603.

Some 90 independent replications of these experiments have provided evidence for a highly significant effect (overall effect size = 0.09, z = 6.4, p = 1.2 × 10 –10 ; Bem et al., 2015 ).

The overlap between DEGs and differential TADs was highly significant ( p = 1.22 × 10 −10 , odds ratio = 3.59), indicating a strong enrichment of DEGs within differential TADs.

Recently, a genome-wide association scan with a subsequent replication study involving over 67,000 individuals (7,473 cases and 42,938 controls) of European ancestry produced highly significant evidence of the strong association of a single nucleotide polymorphism (SNP) rs11177 (C/T) with severe hip and knee OA ( P value = 1.25 × 10 −10 ), a missense polymorphism within the nucleostemin-encoding gene GNL3 19 .

This revealed a highly significant association for rs61748181 (OR = 0.64 95% CI 0.56-0.74, P = 1.28×10 −10 ) that was stronger than that seen for rs35226131 (OR = 0.68 95% CI 0.59-0.79, P = 1.91×10 −8 ).

The two data sets show a highly significant correlation of the categorized expression changes in dauers versus mixed/adult stages for all three species ( P = 1.29 × 10 - 10 , P < 2.2 × 10 - 16 , and P = 2.72 × 10 - 8 for C. elegans , P. pacificus , and S. ratti , respectively, supplementary fig. 6A , C and E, Supplementary Material online).

SCC mec type accounted for a substantial proportion of the variation in excision frequency, with one-way ANOVA showing a highly significant effect ( F (23,48) = 8.92, p = 1.3 × 10 −10 ; R 2 = 0.8104).

5 , the correlation between the time to completion of MI and ME was highly significant in exercise 2 in the amputated group for the intact hand (Pearson’s correlation coefficient, r = 0.72, p = 1.309*10 −10 ) and in the able-bodied control group for the dominant hand (Pearson’s correlation coefficient, r = 0.59, p = 5.461*10 −15 ).

The evidence for directed migration is further supported by a highly significant Rayleigh test (p = 1.32×10 −10 ) demonstrating a unimodal deviation from uniformity or random migration in this instance.

The decrease in TLC in overweight patients was mainly due to a decrease in expiratory reserve volume (ERV) further illustrated by a highly significant ( p = 1.33×10 −10 ) correlation between BMI and ERV.

The results show a highly significant enrichment of essential genes in the TPPIN (p-value = 1.37 × 10 -10 , Table 4 and Figure 5 ).

Highly significant mean R 0 differences were observed between the coalescent and BDSKY (p = 1.4E-10) estimates, as well as between coalescent and surveillance (p = 1.4E-12).

TNFSF-related eQTLs are associated with a variety of autoimmune and autoinflammatory diseases Loci near 24 % of autosomal TNFSF-related genes have been associated with autoimmune and inflammatory diseases by GWAS (Additional file 3 , “Mapped Genes” column), resulting in highly significant enrichment of these gene loci with autoimmune diseases (Fisher’s exact test p = 1.4 × 10 −10 ).