“highly significant”

In both cases the difference is highly significant ( P << 10 −10 ).

The altered group had a significantly higher mutation count (median 158.5) compared with the unaltered group (median 56), with a highly significant difference ( p < 1E-10).

Initially, we restricted our study to SNPs present in both studies with highly significant p -values for T1D and RPS26 eQTL ( p < 10 −10 in both cases).

We observed highly significant differences in ventral gill raker number and spacing between marine LITC and freshwater FTC fish for both wild and lab-reared fish ( P <10 -10 ) for each comparison by Tukey’s HSD test; Figure 1 C, D, Additional file 4 : Figure S3).

The interaction term in a two-way ANOVA with space and shuffled/non-shuffled as factors was highly significant ( F = 15.51, p < 10 −10 ), implying that random spiking cannot fully account for increased feeder representation at the choice point.

These overlaps are highly significant ( P <10 −10 , hypergeometric test).

The difference between the total scores of the study population (29) and the norm population in 1988 (35.79) was highly significant ( p < 10 −10 ) [ 1 ].

5 , 6 , p < 0.05, false discovery rate (FDR) corrected], and in nine such comparisons, results were highly significant (Figs. 5 , 6 , p < 10 −10 , FDR corrected); see Supplementary Data 5 for AUC histogram bin data (bootstrapped resamples).

We find a highly significant improvement in model performance (R 2 of 0.035 vs. 0.14, p < 10 −10 ). 3.2.

We found 1060 upregulated genes in Wit49 and 396 in 17.94, with a highly significant overlap of 212 genes between the two cell-lines ( p < 10 −10 ) ( Figure 3 A).

cerebrum), there was a highly significant correlation ( r = 0.58; P = 1E-10) of methylation changes between the reported sites 29 and our study (Supplementary Fig.

The overlap between MA-line polymorphisms and naturally occurring variants is thus highly significant compared to expectations of overlap based on a random distribution of mutations and polymorphisms ( Figure 5A ) (SNM: Fisher’s Exact test, P = 1e−10; indel: Fisher’s Exact test, P = 6e−5).

These associations were highly significant ( p < 1 × 10 −10 , q < 1 × 10 −10 ).

In this regard, the change in CD66b expression by bound cells was highly significant, p < 10 –10 and P < 10 –5 compared to BSL and CIRC respectively (Fig. 3 c).

Hypergeometric enrichment analyses showed that these overlaps were highly significant ( p < 1e−10), supporting a non-random and biologically meaningful association among these factors (Fig. 3 C).

We observed highly significant enrichment for mQTL at CpGs in ME regions [odds ratio (OR), 6.2; P < 10 −10 , FET] but not in control regions (OR, 1.3; P = 0.09).

Across multiple Glomeromycetes species, chi-square tests of double-base substitution bias gave highly significant P value (all p < 10 − 10 ), and TT>AA, TA>AT, and AT>TA repeatedly showed the strongest positive standardized residuals within the TT, TA, and AT categories, respectively ( Supplementary Tables S4 , available as supplementary material at Bioinformatics Advances online; Supplementary Methods , secti

The darkred gene module had a highly significant correlation between GS and MM with respect to both CVH metrics ( r = 0.39, p -value = 1.0 × 10 −10 ) and BDI-II score ( r = 0.62, p -value = 1.4 × 10 −28 ) ( Figure 3 ). 3.5.

Still, these correlation values were highly significant, also driven however by the large number of observations (p < 10 -10 ).

We found that observation interval was a highly significant factor ( p < 10 −10 ), whereas the effect of the ensemble size was near significance ( p = 0.0758) because of the difference in RMSD error area between k = 5 ensemble member trials and other ensemble sizes.

Results Cross-sectional Analysis between Patients and Controls at Baseline At baseline, we measured a highly significant difference between lesions and healthy tissue for all qMRI metrics ( p < 1e−10).

The downregulated modules include 170 genes ( p < 1e-06), among them 13 highly significant genes ( p < 1e-10): COL10A1 , SAMD9 , PLPP4 , COMP , POSTN , IGHV4–31 , THBS2 , MMP9 , FNDC1 , HOPX , TMEM200A , INHBA , and SULF1 .

Notably, GO analysis of the 708 up-regulated genes did not show significant enrichment in any specific GO category, but the 733 down-regulated genes showed highly significant enrichment in several categories, with the top three (Benjamini adjusted P -value < 1 ×10 −10 ) classified as neural lineage related categories, including ‘neuron differentiation’, ‘transmission of nerve impulse’ and ‘neuron development’ (Figure 1D ).

At the gene level the overlap in repressed genes was highly significant ( p < 1x10 −10 ), consonantly when top repressed genes in T47D cells were evaluated the majority of them were repressed greater than 1.5-fold (Figure 4C ).

A t-test comparing the means returns a p-value of 0.167 (no significant difference) while a 2 sample KS-test returns a highly significant (p-value <10 −10 ) difference between the two distributions.