“highly significant”

Second, our study had excellent statistical power, yielding highly significant MR associations for IFNAR2 ( P =9.8×10 -11 ), increasing confidence in the validity of the much weaker signals for IFNAR2 reported in the GenOMICC study ( P =0.004), particularly as the earlier report had displayed evidence of confounding by LD ( P HEIDI = 0.015). 37 Indeed, compared to the analysi

The differences are highly significant (TT mean – TM mean: P = 9.99E − 11 ; TT mean – TM median: P = 0.0013, KS-test, two-sided, α = 0.05).

We observed highly significant enrichment for mQTL at CpGs in ME regions [odds ratio (OR), 6.2; P < 10 −10 , FET] but not in control regions (OR, 1.3; P = 0.09).

There was a highly significant agreement (Pearson's R = 0.41, P < 10 −10 ) between the model prediction and the measured changes in protein levels, with the model also quantitatively matching the proportional relationship (gradient of slope = 0.75) (Fig 6 F).

There is a good visual agreement between the logos of the simulations and uniref90, and the r values vary between 0.63 and 0.77 (see Table 2 ), which is highly significant (p < 10 -10 ).

Still, these correlation values were highly significant, also driven however by the large number of observations (p < 10 -10 ).

Results Cross-sectional Analysis between Patients and Controls at Baseline At baseline, we measured a highly significant difference between lesions and healthy tissue for all qMRI metrics ( p < 1e−10).

Among these, we identified 339 genes, the expression levels for which showed highly significant (Moran’s I Bonferroni-corrected P < 1e-10) spatial heterogeneity across cells ( Dataset S11 ).

1 B, were 0.45 ± 0.13 (standard deviation) and 0.92 ± 0.07, respectively; the difference was highly significant (P < 10 −10 , t test for paired measurements).

We computed estimated axon conduction velocities from diameters of myelinated and unmyelinated fibers 28 along the proximal to distal axis and observed a strong and highly significant correlation (Fig. 2g , r 2 = 0.83, p < 10 − 10 ).

Numbers in bold indicate highly significant partial correlations ( P < 1 e - 10).

In both cases the difference is highly significant ( P << 10 −10 ).

This difference is highly significant statistically (P < 1.0E-10, Chi-square test).

As most tested associations were highly significant ( p < 10 − 10 ), precise p-values are reported only for those with p > 10 − 10 .

The Pearson correlation coefficients for branching density and asymmetry index ( R = −0.50) and for bifurcation amplitude remote and asymmetry ( R = 0.51) are both statistically highly significant ( p < 10 −10 ).

Of the 4694 SNPs, 389 MTAs were significant at P < 10 −8 , including 88 highly significant MTAs at P < 0.0000000001 (10 −10 ) ( Supplementary Data Table S3 ).

Indeed, we observed a highly significant enrichment of H3K9 methylation at 49 known 26G loci ( Vasale et al. 2010 ) compared to 100 random genes ( P -value < 1 × 10 −10 ) ( Fig. 5C ).

The first four inferred edges are highly significant (p<10 −10 for m = 1 to m = 4), the last one however to a much lesser extent (p = 0.009).

These overlaps are highly significant ( P <10 −10 , hypergeometric test).

The darkred gene module had a highly significant correlation between GS and MM with respect to both CVH metrics ( r = 0.39, p -value = 1.0 × 10 −10 ) and BDI-II score ( r = 0.62, p -value = 1.4 × 10 −28 ) ( Figure 3 ). 3.5.

Post-hoc t-tests showed a highly significant difference between FM (mean number of trials = 37.12; s.d. = 7.3) and FH (mean number of trials = 5.5; s.d. = 2.37) (t 16 = 14.94, P <10 −10 ).

This indeed revealed statistically highly significant (p < 1e-10) overrepresentation of genes encoding cytoplasmic ( AtMDL2 ) and plastid-specific ( AtMDL1 ) ribosomal proteins (Additional file 4 : Table S2; sheet “overrepresented BINs”).

On the basis of counting statistics (binomial distribution), this difference is highly significant ( p << 10 −10 ).

These differences in the proportion of observed gene conversion events in K a and in K s between the RP and MP groups are highly significant ( P < 10 −10 and P < 0.002, respectively; Fisher’s exact test).

3a ), with the logarithm of exogenous cAMP concentration a highly significant predictor of average capsule thickness ( P < 10 −10 ).