“highly significant”

Meta-analysis using the inverse-variance method within METAL[ 29 ] resulted in a highly significant associations with neuroblastoma ( Table 1 ; rs6441201: P = 1.21x10 -11 , Odds Ratio 1.23, 95% CI:1.16–1.31 and rs3796727: P = 126x10 -12 , Odds Ratio 1.30, 95% CI:1.21–1.40; rs3796725: P = 2.08 x 10 −11 , Odds Ratio 1.29, 95% CI:1.19–1.38). rs3796727 genotype correlates with methylation status of C

However, when only the time of the recovery activity was considered, we observed highly significant differences in the caloric consumption between groups ( p = 1.22 × 10 −11 ; Figure 3A ).

4 b, the Kaplan-Meier analyses exhibited highly significant differences in time to overall survival between two different risk groups (hazard ratio [HR], 16.4; 95% confidence interval [CI], 5.68–47.3; p = 1.263e-11).

In general, the Kruskal–Wallis test indicated a highly significant association between subcutaneous fat thickness and the occurrence of fractures, regardless the experimental group ( p = 1.29 × 10 –11 ). 3.3.

While all correlations were highly significant (all p < 1.3e-11), the neurovascular/haemodynamic parameters ( τ , κ , ε ) were estimated less accurately and were more sensitive to the SNR than the pRF parameters.

The number of true phenotype-related genes found among the top 10 candidates, for example, was highly significant ( P = 1.38e-11 for N = 50, P = 6.77e-14 for N = 100, and P = 4.79e-09 for N = 200).

Not surprisingly, a Wald test indicates that the odds of a contact event detected by a card being reciprocated is estimated to be 4.748 (3.022, 7.462) times higher than that of a contact event reported in case investigations, a highly significant difference ( z = 6.755, p = 1.433 × 10 − 11 ).

Validation of the GRS in the analysis of incident conditions As shown in Table 3 , dGRS 1000 had a highly significant effect (HR = 1.48, 95% CI: 1.32–1.66 per 1 SD; P = 1.5 × 10 −11 ) on the risk of developing T2D during follow-up and accounted for a large set of known covariates.

Statistical comparison with models trained with baseline, or week 2 data, show highly significant differences (p = 1.6e-11, p = 2.4e-13, respectively) although only an overall modest mean performance improvement of 3.1 and 3.4% respectively. 3.4.

The finding was successfully replicated in an independent set of samples from Iceland, Denmark, Germany and the Netherlands encompassing 3202 cases and 40,062 controls and was highly significant in an overall meta-analysis ( p = 1.69 × 10 − 11 , odds ratio = 1.18).

The overlaps between Rio1 and the heat, osmotic, and nutritional regulons remained highly significant ( P -values = 1.7E-11, 3.2E-23 and 2.9E-12, respectively), indicating a shared response to extracellular cues that covers but also extends way beyond regulating ribosome production and activity.

Consequently, the association of this variant with echocardiographic changes in the entire echocardiographic Dobermann cohort (“echo only,” “echo + arrhythmia,” “CHF,” and “healthy” subcohorts; Utrecht cases; and the Uppsala cohort) was highly significant ( P = 1.72 × 10 −11 , χ 2 = 45.26, df = 1).

There was a highly significant difference in the distribution of anatomical origin among lumbar OCs ( p = 1.8 × 10 −11 ), with the inferior articular process being the most frequently involved site, followed by the spinous process and other locations.

1 C), revealing a highly significant semidominant effect on body weight ( P =1.828×10 −11 ).

By performing positive correlation coefficient analysis, we discovered a highly significant correlation between the brown module and AD (correlation coefficient = 0.96, P = 2e-11, Fig. 2 C), which encompassed 228 core genes.

PD comparisons were highly significant (P < 2 × 10 -11 ).

The strongest evidence came from the MetaBrain cortex resource, where the top overlapping DACT1 eQTL showed a highly significant association ( p = 2.18×10 −11 ).

2A ), but we found a highly significant negative relationship between SNV density and the probability that metaFlye would assemble a cMAG (logistic regression coefficient, –1.35, P = 2.18 × 10 –11 , n = 575).

Functional enrichment analysis of this set of 46 genes using FatiGO ( http://babelomics.bioinfo.cipf.es ) revealed a highly significant enrichment (Fisher exact test, two-tailed, p = 2.24 e-11 ) for genes annotated with gene ontology (GO) term GO:0006952 (defense response), with 39.1% (18/46) of the upregulated genes associated with this term, compared to 2.61% in the whole Arabidopsis genome.

The P -value for this modified test was also highly significant (FDR corrected P = 2.26E−11), demonstrating that the increased evolutionary rate of Trpc4 in bats is not an artifact of shifts in GC composition or extreme synonymous rate variation ( Ratnakumar et al., 2010 ; Wisotsky et al., 2020 ).

The correlation of effect size estimates of these SNPs between our study and the original report (Stage 1+2) was highly significant although not perfect (Pearson ρ = 0.472, P = 2.32×10 −11 ).

However, Chromosome 15 showed a highly significant, ∼41% reduction in sequence variation relative to the rest of the genome (ANOVA: F = 45.668, d.f. = 1, p = 2.34×10 −11 ; Fig. 3A ).

The overlapped pathways were highly significant P = 2.36 e − 11, hypergeometric test.

By calculating a DNA methylation score (Methylation score) for each single cell and displaying it on a UMAP plot ( Figure 4A ), we found that cells in PDAC samples generally have higher DNA methylation scores, showing highly significant differences compared to ADJ samples (p = 2.4e-11, Figure 4B ).

The resulting ICC(A,1) was 0.99 (95% CI: 0.0967-0.997), and the F-test confirmed that this level of agreement was highly significant (F(15, 10.6)=250, p=2.42x10 -11 ).