“highly significant”

Results: A highly significant association with CD was observed, with the strongest signal at coding variant Arg381Gln (allele frequency, 2.5% in CD vs 6.2% in controls [ P = 1.1 × 10 −12 ]; odds ratio, 0.38; 95% confidence interval, 0.29–0.50).

Furthermore, a hypergeometric test indicated that the identification of 18 seasonal genes out of 363 may have occurred by chance ( p = 0.4233), whereas the 87 vitamin D target genes among the 873 circadian genes were highly significant ( p = 1.1976 × 10 −12 ).

Identification of genes differentially methylated between PCNSL and hematopoietic controls PCA based analysis applying most stringent conditions differentiates normal controls from both PCNSL and systemic DLBCL samples in a highly significant fashion (p = 1.2 × 10 -12 , q = 3.9157 × 10 -11 ; Fig. 1A ). 33 CpG loci (corresponding to 30 genes) differentiating between PCNSL and controls performed in replicates were significantly hypermethylated while three CpG loci showed hypomethylation in PCNSL compared to hematopoietic controls (Fig. 1B ).

For heat resistance (CTmax), males became less tolerant with increasing age as we observed a significant negative slope with age in the regression (p = 7.91e-23), whereas for females, their resistance to heat is not changed with age suggested by the highly significant positive interaction effect (p = 1.20e-12) (Table 1 , Fig. 1B ).

Network enrichment analysis revealed a highly significant functional network (19 nodes, 29 edges; PPI enrichment p = 1.3e-12), with TNF emerging as the central hub ( Supplementary Figure 3G ).

The C-786 mutant group, however, was more common in Caucasians (14.5%) compared to Africans or African Americans (3.2% and 1.8% respectively) and this difference was highly significant (χ 2 = 61.64; P = 1.312 × 10 −12 ).

A highly significant, negative correlation was also observed between this DMR and MAB21L2 (r = −0.66, p = 1.35 × 10 −12 ), but not LRBA .

Genotype analysis of 168 pups at weaning revealed that only two Tbx1 +/– ;Pax9 +/– mice were alive, a highly significant deviation from the 42 expected of each genotype from this cross ( P =1.4×10 −12 ; Table S2 ).

Tdrd7 was differentially transcribed between tissues, with a moderate but highly significant upregulation in the gonads (~ 2.5 times more transcribed considering pooled sexes; p -value = 1.4e−12).

For example, Lee et al reported a comprehensive HCC gene signature on a Chinese-Belgium dataset that overlapped our results in a highly significant manner (4.8 fold enrichment; Fisher Exact Test p-value = 1.4E-12 for the tumor tissue DFS signature, Table 1 and 2 ).

Interestingly, we observed a highly significant decrease in mtDNA copies in the SS patients compared to healthy controls ( p = 1.44 × 10 −12 ).

Notably, we obtained highly significant ORs for rs7903146, including the pooled OR for the T allele versus the C allele (OR = 1.54, 95% CI: 1.37 – 1.74, p = 1.47 × 10 -12 , I 2 = 25.20%) and the OR for heterozygotes versus C homozygotes (OR = 1.56, 95% CI: 1.38 – 1.76, p = 8.25 × 10 -9 , I 2 = 21.00%) (Figure 3 ).

For grain Na + content we observed a single highly significant association on the bottom of chromosome 4HL for the marker SCRI_RS_142792, with a −log10(p) = 11.8, FDR adjusted p -value = 2.2E-08, and an R 2 = 0.45 (Fig. 1b ) consistent with prior genetic analyses of shoot Na + content 19 – 21 .

More generally, there was a highly significant enrichment for KAP1-bound LTR12C integrants within 50kb of the TSS of upregulated genes (Fisher test, adjusted p-value = 1.6E-12) (Fig.

Gene expression was consistently downregulated in all stages of KIRC compared to normal tissue, with highly significant p-values observed in stage 1 (p=1.62×10 -12 ), stage 2 (p=1.52×10 -11 ), stage 3 (p<1×10 -12 ), stage 4 (p=1.62×10 -12 ).

To statistically evaluate the differences in binding energies, a Kruskal–Wallis test was conducted, yielding highly significant results for both GNINA ( p = 1.725 × 10 –12 ) and Autodock rescoring ( p = 1.514 × 10 –12 ), confirming that binding energy distributions across receptors are not equivalent.

Here, we sorted all genes expressed in the liver ( N = 13.426) based on gene length and clustered them in bins of 500, revealing that increased dietary protein intake triggers GLTD as indicated by a statistically highly significant downregulation of longer genes in LCHP vs LPHC diets (Fig. 3H , p = 1.89E-12).

Notably, eight genes were consistently identified across both platforms (BAIAP2L2, EEF1A2, EPHA7, HNF1B, MMP24, PTHLH, SAA2, and VNN1) and were highly significant (hypergeometric test, p-value = 1.97 × 10− 12 , 89-fold enrichment over expected by chance), validating the consistency of our findings across different technological platforms (supplementary Table 2).

For all datasets, the correlation between online hits and offline replay content was highly significant ( χ 2 >50, p< 2 × 10 - 12 ).

There is a highly significant positive relationship (Spearman’s r = 0.75, p < 2E−12); between the number of humans in a county and the number of viral cases; however, the population-scaled viral cases do not have a strong relationship (Spearman’s r = 0.05, p = 0.03) with human populations ( Fig. 2 ).

Using all four cofactors and their interactions (sex, body weight, age and litter identifier), the F ratio associated with strain was 26.913, and while this value was highly significant ( p < 2E-12, 3 df) the corresponding estimate of narrow sense heritability ( h 2 ) was modest—approximately 0.11.

Both parental and sibling correlations were indeed found highly significant for effect 1, RTE T reg CD25 (ρ P = 0·73/ P = 2E‐12; ρ S = 0·70/ P = 5E‐8), indicating a high heritability.

The result is highly significant for worse overall performance of the 7XU plans (p = 2e-12).

Indeed, on average, the percentage contribution of such cells to the ICMs of each assayed and p38-Mapk14/11 inhibited group only represented 14.2%, 10.8% and 14.1% (when assaying for Gata6, Sox17 and Gata4, respectively) compared with an average of 36.9% in control embryo groups (when considered together across the three assayed conditions); PrE cell number reductions were associated with highly significant p -values (i.e. < 0.005, two-tailed Student's t -test; p = 2.21 × 10 −12 , 8.40 × 10 −7 and 2.54 × 10 −12 , when respectively assaying Gata6, Sox17 and Gata4).

As expected, there was a highly significant positive effect of age on number of diagnoses ( p =2.34E-12, Table 2 and Fig. 2 ).