“highly significant”

To test this more formally, we assessed baseline pupil size in our a priori baseline time window −1 to 0 s and found a highly significant difference in pupil size preceding certain vs. uncertain choices ( β C > 0 , t = 6.9 , p ~ 10 − 12 , CI = 0.03 , 0.05 ) (Figure 2A , inset bar plots).

9B ) shows functions related to “Cellular Movement, Hematological System Development and Function, Immune cell trafficking and cell-mediated immune response”, with a highly significant score of 12 (p = 10 −12 ) (Fig. 9 ).

neurons 21 to 100) highly significant (t-test; p < 10 −12 ) ( Fig 7C , right).

In our HSA14 simulations, the presence of heterochromatin slightly reduces the absolute value of the correlation, which however remains highly significant (Spearman correlation r ≃ −0.83, p < 10 −12 ).

The difference in substitution scores between core and surface region is highly significant for both SVD and CSM ( P <1.0 −12 ) and significant for SVP ( P <1.0 −4 ), whereas it is not significant for SAP ( P <0.78).

Results The differences in the distribution of SE between the wake and N2, and wake and N3 were highly significant ( p < 10 − 12 for both comparisons), whereas the difference between the wake and REM states was not ( p = 0.12 ).

The Chi-Square test showed a highly significant correlation of all tests with the latent class (p < 10 12 or lower).

Of the 119 genes that were both represented in the MCF-7 dataset and increased in EGFR -mutant NSCLC cells, 44 (31%) were increased with P <0.05 in EGFR -transfected MCF-7 cells, which represented a highly significant overlap ( P <1E–12, one-sided Fisher's exact test, Fig. 2 E ).

Notably, a highly significant enrichment of RGAC motifs at NKAP-binding footprints (CIMS or CITS along with a 5-nucleotide flanking sequence) was identified by iCLIP-sequencing ( P < 10 −12 , Wilcoxon rank-sum test, Fig. 5g ), suggesting that NKAP preferentially binds the m 6 A core motif RGAC.

The general lack of diagnostic specificity is also apparent in the Spearman's rank correlations (Table 4 and Supporting Information Tables 2 and 3), as for each pair of diagnoses, correlation coefficients across regions ranged between 0.42 and 0.82 and were highly significant (0.001 < P < 10 −12 ).

The DEG group with stress-induced downregulation (blue) demonstrates a highly significant ( p < 10–12) positive correlation between PC1 and PC2.

Pearson correlations with PC[1] scores were highly significant ( P < 10 −12 ) for height ( R , 0.65), yield ( R , 0.56) and growth rate ( R , 0.62).

An unanticipated outcome was the finding of a highly significant (p < 1 × 10 −12 ) relationship with up- and down-regulated genes encoding effectors of the DNA damage response, including BRCA1 , CHK2 and RAD51 , among many others (Supplemental Fig.

The overrepresentation of mutations in subtelomeric regions is highly significant in O. tauri (10 vs. 94 mutations in subtelomeric versus nonsubtelomeric regions, Fisher exact test, P -value <10 −12 ), B. prasinos (8 vs. 24 mutations, Fisher exact test, P -value <10 −12 ) and M. pusilla (4 vs. 81 mutations, Fisher exact test, P -value <10 −4 ).

In this ANCOVA the effect of phenotype is not significant ( P = 0.09) while expression level is highly significant (P<10 −12 ).

Because this method allowed for the simultaneous quantification of many peptides per protein, the changes induced by both cell treatments were found to be highly significant ( P < 1 × 10 −12 and P < 1 × 10 −29 for eIF4G and eIF4A, respectively).

The direct comparison of all 1-kb regions reveals that this higher B in the X chromosome relative to autosomes is highly significant (Mann-Whitney U Test, P <1×10 −12 for complete and trimmed chromosomes), with all BGS models generating the same trend and level of significance.

The MUA response to visual stimuli (median 0.1 SD above baseline) was not significantly different from 0 (sign-rank test p = 0.6), while the responses to auditory (median 2.7 SD) and audio–visual stimuli (median 1.6 SD) were highly significant (sign-rank tests, p < 10 −12 and p < 10 −9 ).

Gene pathways up-regulated by age in all three tissues were complement genes, apoptosis and interferon gamma response pathway genes, albeit this upregulation was highly significant (hypergeometric test, p < 10 −12 – 10 −20 ) in the old kidney and less significant in the old liver and skeletal muscle ( Figure 2 ).

Furthermore, analyzing the sample similarity based on these cluster frequencies resulted in highly significant grouping of samples with the same diagnosis ( P < 10 −12 ; Fig. 3E ).

When we applied Fisher's exact test to gene sets identified by the different approaches ( Supplemental Figure S3A–C ), we always found highly significant overlap (more genes in common than expected by chance) between the SB Driver Analysis and GKC analysis methods ( P < 10 −12 ).

CC15 exhibited highly significant associations with both ant(4’)-Ia and lnu(A) ( P = 1.01E-12, OR = 583.8 for both).

A chi‐squared test confirmed a highly significant association between vector construct and co‐transformation frequency ( χ 2 (3) = 58.87, P = 1.03 × 10 −12 ).

A statistical analysis using the chi-square test of independence revealed a highly significant difference between the groups (χ 2 ≈ 43.6; P < 1.04 × 10 –12 ), confirming that a full stomach exerts a protective effect on the pars oesophagea and significantly reduces the risk of ulcerations.

Indeed, of the 1,734 KHSRP targets identified in Winzen et al, 43 245, or 14%, overlapped with the 1,589 ischemia-stabilized mRNAs, an overlap that was highly significant via normal approximation of exact hypergeometric probability (Representation factor: 1.5, p < 1.064e −12 ).