“highly significant”

The effects of instar, direction of photoperiod shift and their interaction were highly significant ( χ 2 = 63,27, d.f. = 5, p = 2.56 × 10 −12 , χ 2 = 125,87, d.f. = 1, p < 2.2 × 10 −16 , d.f. = 5, χ 2 = 14,18, p = 0.015, respectively).

As we observed in YPA, mRNAs encoding components of the mitochondrial electron transport chain (ETC) were highly significant targets of JHD2 -repression in YAR ( p < 2.6e-12, Supplementary Table 5 ).

This number of interactions is higher than the expected value (94), indicating that the network was not formed by chance, as supported by a highly significant p -value (PPI enrichment p -value = 2.67 × 10 −12 ).

Finally, a highly significant decrease in H 2 O 2 release was observed in Down Syndrome (DS) individuals (p<2.88×10−12).

Furthermore, individuals possessing at least one copy of the minor T allele of the IL6R SNP rs4537545 expressed higher levels of sIL6R than those homozygous for the major C allele (averages 42.84 ng/mL and 29.36 ng/mL, respectively, data not shown), and this difference was highly significant ( p = 2.98×10 −12 ).

All six models listed include cannabinoids with highly significant positive terms (from β-est. = 3.67 (2.77, 4.56), P = 3.06 × 10 –12 ) in model four) and in all six models the effect of cannabinoids is positive overall.

The test revealed a highly significant difference between the study areas ( p -value = 3.08 × 10–12).

Similarly, this association was also highly significant when only considering abundant variants with >9 sequences (p = 3.082 × 10 −12 ).

A chi-square analysis revealed a highly significant association between HbS positivity and thalassemia type ( P ≈ 3.1 × 10 −12 ), which aligns with the diagnostic role of HbS detection in sickle cell thalassemia.

In our meta-analysis, the direction of the association was not consistent across different cohorts and the lead SNP showed highly significant ancestral heterogeneity ( P = 3.23 × 10 –12 ).

S1 ), Chrs 1, 3, 5, and 10 were selected for closer inspection because these chromosomes each possessed one or three LD blocks with highly significant SNP associations (–log 10 ( P ) ≥ 11.49) with many traits (≥ 8) (Fig. 3 , Table S6 ).

Analysis of variance (ANOVA; marginal test with Satterthwaite degrees of freedom, Type III test of fixed effects) shows that there is a highly significant main effect of size (large/small) on duration thresholds ( F 1, 37 = 102.54, p = 3.25 × 10 −12 ).

A third event extended across positions 2661 and 2717, where TYLCV ( KJ830842 ) served as the major parent and an unidentified TYLCV isolate ( ON756218 ) as the minor parent, supported by a highly significant probability ( p = 3.30 × 10 −12 ).

For IgG, t-tests indicated highly significant elevations in case samples of ABPA ( p = 3.36 × 10−12), and SAAS ( p = 4.80 × 10−9); and control samples of HDM ( p = 2.81 × 10−14), and FA ( p = 0.001), with non-significant changes in RTI ( p = 0.193) and UTI ( p = 0.242).

This difference in prevalence was highly significant ( z = −6.949, SE = 2.807, p = 3.67 × 10 −12 ), with fin tissue being less effective in detecting Ranavirus .

A total of 53% of all mCpol systems are encoded in genomes also coding for systems centred on SMODS-domain enzymes (cGAS/DncV-like nucleotidyltransferases (CD-NTases)), a highly significant linkage ( P = 3.7 × 10 −12 ) indicative of functional coupling between them (Fig. 5b and Extended Data Fig. 9b,c ).

These differences were highly significant for both comparisons (two-sided Wilcoxon rank sum tests, P = 3.716 × 10 −12 , n = 21, Figure 1B ).

Statistical analysis using the Fisher's exact test showed a highly significant separation based on ER-status with p = 3.914e −12 .

In the combined sample, after adjusting for country of sampling, this sex difference is highly significant: males are on average more lightly pigmented than females by 1.57 M index units (95% CI = 1.14–2.01, p = 4×10 −12 ).

This 3.8 fold difference was highly significant (t-test, p = 4 X10 -12 ).

Overall, there were highly significant differences with medium to large effect size when comparing controls vs. patients (F(1) = 52.65, p = 4.05 × 10 −12 , ω 2 p = 0.15), visual areas (F(2) = 66.39, p = 2.88 × 10 −24 , ω 2 p = 0.3), and stimulus type (F(3) = 13.73, p = 2.27 × 10 −8 , ω 2 p = 0.11).

rs138213197 remained highly significant in this analysis ( P = 4.2×10 −12 , Table 1 ) and with an effect size substantially greater than that observed through any of the common variants and broadly similar to that previously reported in the literature (OR = 3.88, 95%C.I. 2.64–5.70).

The highly significant effect of relationship quality on MIPPE scores (p = 4.4e-12) demonstrates the scale’s discriminant capacity.

Overall, there was highly significant evidence of association between the minor allele at rs876498 and type 1 diabetes (OR 1.10 [95% CI 1.07–1.13]; P = 4.4 × 10 −12 ).

Comparison of this list with the top 20 genes from the original analysis ( Table 1 ) revealed 14 overlapping genes, a highly significant overlap ( p = 4.401E−12).