“highly significant”

The combined analysis of all four studies including a total of n = 1,910 cases and n = 3,630 controls showed highly significant evidence for association between rs1739843 and idiopathic DCM (p = 5.28×10 −13 , OR = 0.72 [95% CI 0.65–0.78]).

The age x genotype within sex interaction was also highly significant ( p = 5·5 × 10 −13 ).

The comparison of the fixed effects of the rs181206[G] allele resulted in highly significant estimates: β ^ m u t a n t = -1.11 ( P = 5.52x10 -13 ) for IRF1 and β ^ m u t a n t = -1.28 ( P = 4.86x10 -10 ) for STAT1.

A pooled dataset, consisting of 19 studies with long-term clinical follow-up, also demonstrated a highly significant (p= 5.80 × 10 −13 ) inverse correlation between DICER and hypoxia.

Each of these additive effects were highly significant (F statistic > 60, d.f. numerator , = 1, d.f. residuals = 175, p < 6 x 10 −13 ; Fig 4 ; Table 1 ).

The most prominent peak was detected on chromosome 19 at position 45,281,163 bp, with a highly significant P-value of 6.03 × 10 –1 3 (-log 10 (P) = 12.22).

The coding region (CDS) of these genes also contained a highly significant enrichment for hexamer seed matches (p = 6.1E-13).

The overlap between early and late was highly significant ( p = 6.4e-13, Fisher test).

For example, we found highly significant functional enrichment among the interacting partners for the GO terms “cytoskeleton” (P value = 6.6 × 10 −13 ), “TFIID complex” (P value = 1 × 10 −14 ), and “proteasome” (P value = 6.6 × 10 −13 ) ( Haarer et al. 2011 ).

This difference in proportion Metazoan is highly significant (P = 6.91×10 −13 , Fisher's Exact Test); induced genes are also much more likely to be wasp-specific (31.3% induced, 16.3% other genes, Fisher's Exact Test P = 8.85×10 −7 ).

The ANOVA results revealed highly significant differences among treatments for both Tret1 ( p -value = 7.78 × 10− 13 ) and Tret1-like ( p -value = 1.32 × 10− 13 ), both far below 0.0001 significance p- value threshold, indicating that exposure to insecticides and acetone markedly affected gene expression.

Sylamer analysis using all 7-nt motifs complementary to seed regions of mouse miRNAs revealed a highly significant (P < 8 × 10 −13 ; Bonferroni corrected < 7 × 10 −10 ) enrichment for the 7-nt seed match of miR-451 (AACGGTT) in the 3′ UTRs of genes in a cohort of 588 genes, most of which were up-regulated in miR144/451 −/− erythroid precursors ( Fig. 4 B ).

For both models and both states, there are highly significant differences in importance values across the three classes of phenotypic impact (RF MN: P = 8.15 × 10 − 13 ; RF TX: P = 2.20 × 10 − 16 ; FFNN MN: P = 2.20 × 10 − 16 ; FFNN TX: P = 2.20 × 10 − 16 ).

The proportions were 0.962 ± 0.040 for AAV1-labeled neurons and 0.492 ± 0.066 for FluoroGold-labeled neurons, indicating a highly significant difference ( p = 8.6 × 10 –13 , Wilcoxon rank-sum test).

We observed that the tumor types with highly significant KDM7A-DT gain and amplification were highly aggressive, including hepatocellular carcinoma ( p = 8.8E-13), pilocytic astrocytoma ( p = 3.43E-10), melanoma ( p = 5.21E-10), prostate adenocarcinoma ( p = 5.16E-08), medulloblastoma ( p = 4.20E-07), and colorectal carcinoma ( p = 6.14E-04).

However, the death rate was 34% in co-infected ( n = 170) compared to non-co-infected patients ( n = 128), indicating a highly significant value ( p -value = 0.00000000000088).

Conversely, the variety has a very highly significant effect ( p = 9 × 10 −13 ) on the intercepts of these relationships.

The genotypes (RIL and accession) had a highly significant effect in both populations ( P -values ≤ 9.92e−13).

The survival difference is highly significant (log-rank p < 10 −12 , hazard ratio = 1.72, 95% CI: 1.58–1.89), annotated in the upper right of the panel.

The MUA response to visual stimuli (median 0.1 SD above baseline) was not significantly different from 0 (sign-rank test p = 0.6), while the responses to auditory (median 2.7 SD) and audio–visual stimuli (median 1.6 SD) were highly significant (sign-rank tests, p < 10 −12 and p < 10 −9 ).

Results The differences in the distribution of SE between the wake and N2, and wake and N3 were highly significant ( p < 10 − 12 for both comparisons), whereas the difference between the wake and REM states was not ( p = 0.12 ).

Furthermore, analyzing the sample similarity based on these cluster frequencies resulted in highly significant grouping of samples with the same diagnosis ( P < 10 −12 ; Fig. 3E ).

Indeed, we found the correlation between rankings of two reported lists was positive (Spearman’s correlation coefficient ρ = 0.68) and highly significant (p value < 10 −12 ).

The general lack of diagnostic specificity is also apparent in the Spearman's rank correlations (Table 4 and Supporting Information Tables 2 and 3), as for each pair of diagnoses, correlation coefficients across regions ranged between 0.42 and 0.82 and were highly significant (0.001 < P < 10 −12 ).

We found a highly significant ( p < 10 −12 ) positive ( R 2 > 0.51) correlation between levels of expression of 2071 transcripts whose expression was affected by both stimuli.