“highly significant”

Analysis of Molecular Dynamics Trajectories for Effect of Mutation on the Protein Structure Among the significant mutations, we found S194L in the N protein to be highly significant ( p -value = 2.35481E-13) and exclusive to the mortality patients.

These results generally confirmed our RF inferences; for example, bio8 was still a highly significant ( P = 2.40 × 10 −13 ; Table S3 ) predictor after correcting for genetic relatedness.

We identified a highly significant enrichment of imprinted genes involved in the placental somatic duplications (21/1,180 duplicated genes vs 214/57,952 Ensembl genes; P = 2.67 × 10 −13 ) ( Table 4 ).

In this analysis, we identified a highly significant overlap P-value with a positive correlation between the DG of adult Cn mutants (mutants vs. controls) and the DG of infant mice (2-week-old vs. 1-month-old) ( P = 2.7 × 10 –13 ; Fig. 3 d and e, Additional file 2 : Table S5), indicating a significant similarity in the gene expression patterns between them.

Specific KEGG Signaling Pathways and Common Peptides Further evaluation of three highly significant pathways ( P < 2.7 × 10 −13 ) showed that the T cell receptor pathway, TNF signaling pathway, and NF-B signaling pathways shared common peptides that were significantly different between jejunal samples from chickens on the control diet compared to those on the supplemented diet Table 5 . shows the significant peptides within the T cell receptor pathway, TNF signaling pathway, and NF-κB signaling pathways.

Influence of Phylogeny and Disturbance-Induced Thaw on ARGs Although the abundance of ARGs increased with FPES disturbance levels (UD = 101, SD = 133, MD = 145), we found the number of CARD hits per isolate was highly significant by phylum (Kruskal-Wallis p = 2.8 × 10 −13 ; Figure 3 a) rather than FPES site (Kruskal-Wallis p = 0.083; Figure 3 b).

Correlation between Hong Kong Red List and four traits At the national scale, Spearman’s rank correlation indicated a weak but statistically significant positive association between China Red List status and habitat ( r s = 0.153, P = 0.0062; P < 0.05), and a negligible yet highly significant positive correlation with trade ( r s = 0.009, P = 2.956E-13; P < 0.001).

The reduction of RUNX1 expression in high-grade tumors is highly significant (p-value = 3×10 −13 for the Ivshina dataset and p-value = 2.5×10 −9 for the Lu dataset by linear regression model analyses).

The difference was highly significant ( p = 3∗ e −13 ).

Highly significant differences were also observed with PTPN14 ( p < 3.2e−13), SDC4 ( p < 3.2e−13), CKAP4 ( p < 3e−12), ADAM9 ( p < 3.3e−11), and PIK3CG ( p < 2.3 e−10).

The overlap between our data and all cancer types in TCGA was highly significant, both for miRNAs within a fusion transcript in at least one tumor (odds ratio 2.93, 95% CI [2.15–4.03], p = 3.29 × 10 −13 , Fisher’s exact test), for miRNAs recurrent in our data and with at least one fusion in TCGA (odds ratio 2.99, 95% CI [2.29–3.93], p < 2.20 × 10 −16 , Fisher’s exact test), as well as for miRNAs recurrent in both data sets (odds ratio 3.03, 95% CI [1.75–5.39], p = 2.62 × 10 −5 , Fisher’s exact test).

The linear correlation coefficient between the two mRNAs after log transformation was negative and highly significant ( r = −3.36, p = 3.34E-13).

Methylation changes within exons showed a weak but highly significant inverse correlation with changes in gene expression ( R = −0.043, P = 3.40 × 10 –13 ).

We found a highly significant main effect of stimulus modality on PSE shifts (Monkey M: β = 31.07, t (44) = 10.22, p = 3.412 × 10 −13 ; Monkey P: β = 6.044, t (44) = 8.457, p = 3.394 × 10 −9 ), as well as moderate evidence for an interaction between stimulus modality and self-motion amplitude (Monkey M: β = 733.5, t (44) = 3.016, p = 4.248 × 10 −3 ; Monkey P: β = 67.78, t (28) = 2.371, p = 0.02487).

We found that the protein products of genes within the WGCNA modules had highly significant functional interactions forming densely interconnected networks ( Fig. 14 A , mouseUP module, 1,136 nodes; average node degree, 8.2; PI enrichment p value = 3.56 × 10 −13 ; Figure 14 C , mouseDOWN module, 712 nodes, average node degree, 15; PI enrichment p value < 1.0 × 10 −16 ).

Rank correlation coefficients suggest that the coincidence between temperature- and retinal sensitivity is highly significant among TM2 variants (ρ = 0.37. p = 3.6 × 10 −13 ) but not among TM7 variants (ρ = 0.01, p = 0.79).

These differences were highly significant by one-sample ANOVA (F = 16.1, p = 3.84E-13).

Once again an F-test was performed, looking for an effect of disease status in the presence of age and study site and allowing for an interaction between disease status and age; the result was highly significant (p = 4 x 10 −13 ).

The PNPLA3 rs738409 risk allele (G) remained highly significant, even when the two APOC3 variants were included in the model ( P = 4.06 × 10 −13 ).

The data were analyzed using log transformation of GDF15 levels ( Figure 2b ) and a highly significant relationship with the reciprocal of pre-pregnancy BMI was apparent (standardized β=0.266, p=4.1×10 -13 , n=721).This relationship was replicated in the NIPTeR Study ( Figure 2c & d ; standardized β=0.280, p=1.5×10 -5 , n=231).

All R values shown in the scatter plots were highly significant for SC and BP choices (SC&BP-graded regions in Fig. 5 c: R = 0.17, p = 4.3 × 10 −13 and R = −0.15, p = 7.8 × 10 −12 ; SC/BP-graded regions in Fig. 5 d: R = 0.26, p = 3.3 × 10 −28 and R = −0.19, p = 2.0 × 10 −21 ; SC&BP-graded parietal region in Fig. 5 e: R = 0.17, p = 2.9 × 10 −6 and R = −0.16, p = 1.3 × 10 −6 ; two-tailed Spearman’s correlation).

We use PROPER to predict multicopy suppression in Escherichia coli , achieving highly significant overlap with published cases (hypergeometric p = 4.4e-13).

As noted in the main text, this relationship is highly significant (Spearman's rho = −0.20, p = 4.75e-13).

The difference was highly significant (Kruskal–Wallis χ 2 = 63.7, df = 4, p = 4.9 × 10 −13 ).

Overall ANOVA for N = 6 independent experiments shows that the overall changes due to the presence of the blockers is highly significant ( p < 5 × 10 − 13 ).