“highly significant”

Positive correlations between the differentially expressed genes The Pearson Correlation test performed between the 115 significantly changed transcripts in all 59 patient and control samples identified 54 highly significant correlations (threshold: r > 0.8 and P < 10 -14 , Additional file 5 , Table S4).

A correlation analysis of the Spearman rho statistics between the two clusters is highly significant (rho = 0.39, p < 10 -14 ; using newborns declared as only one race, N = 162, rho = 0.41, p < 10 -14 ), indicating that similar trends exist in both groups.

For the two metrics, the difference in performance is highly significant between each pair of models (p < 10 −14 ).

Focusing on the 1 Mb region surrounding each gene (and correcting for cancer type and CNA), 82 genes with FDR < 10% for each dataset overlapped between both results sets, a highly significant overlap ( p < 1E−14, one-sided Fisher’s exact test, Fig. 2 d).

2 B, the time required to curate each case demonstrates a leftward shift in the distribution for S-BCAW relative to MICAW, with a highly significant difference ( p = 1.07E-14).

We detected a small but highly significant association between the anhedonia PRS and the anhedonia phenotype scores (β = 0.0007, p = 1.17 × 10 –14 ).

The enrichment of expressed genes in the set of active promoters was highly significant ( P = 1.2 × 10 −14 ).

Highly significant differences were detected between calculations using Phylomatic and the unconstrained (t = -9.7575, df = 69, p-value = 1.271e-14; t = -14.686, Barocode only: df = 67, p-value < 2.2e-16), as well as the constrained (t = -12.365, df = 69, p-value < 2.2e-16; Barcode only: t = -17.857, df = 67, p-value < 2.2e-16) barcoding ML analyses ( Fig 5 ).

At α = 0.05, there were highly significant differences among the predicted genotypic effects ( P = 1.33e-14) when compared to the population mean (μ) (Supplementary Table 2 ).

The omnibus ANOVA demonstrated highly significant differences between groups (F = 32.52, p = 1.36 × 10 −14 ), confirming that complexity scores correspond to measurable differences in clinical effort and resource utilization ( Table 4 ).

After 24 hours, we quantified luciferase activity and found a highly significant effect of group (One-way ANOVA, F = 169.95; df = 4; p = 1.37 10 −14 , Figure 4 B).

Comparative analysis of the paired samples revealed highly significant overexpression of NDC80 mRNA in ccRCC samples from TCGA (p = 1.4e-14) and ICGC (p = 1.2e-11) ( Figures 2 B and 2C).

For sites within genes, MLV showed a highly significant bias in favor of integration near transcription start sites ( p = 1.4 × 10 −14 ).

Despite these conservative summaries, paired Wilcoxon signed-rank tests on the encounter-level differences demonstrated highly significant separation: median ΔP_event for censored levels exceeded that for onset levels (p ≈ 1.4 × 10 −14 ), and median W_event for censored levels similarly exceeded onset W_event (p ≈ 3.1 × 10 −11 ).

The results indicated a highly significant slower pace of potentially functional mutations ( P = 1.42 × 10 −14 ) ( Fig. 3 ).

When comparing measurements from two observers, they exhibited a highly significant correlation coefficient (r = 0.98, p = 0.143 × 10 −13 ).

The correlation of the probability estimates of the models from the hippocampus and frontal cortex was highly significant and of moderate strength ( ρ = 0.41, p = 1.5e−14; Additional file 1 : Fig.

Acquisitions of 14.5 min duration performed on anesthetized, spontaneously respiring animals, without gating and administration of contrast agent resulted in a highly significant correlation (R = 0.98, p = 1.5 × 10 −14 ) between the MRI-derived liver volumes and the post-mortem liver weights in hepatectomized, untreated mice. 1,4-bis [2-(3, 5-dichloropyridyloxy)] benzene (TCPOBOP), a synthetic agonist of the mouse constitutive androstane receptor and a potent activator of cytochrome P450 monooxygenase activity ( Halwachs et al., 2007 ) shown earlier to induce hepatocyte proliferation and hepatomegaly ( Ledda-Columbano et al., 2000 ), was then evaluated as test compound in the model.

This contribution was highly significant ( p = 1.5 × 10 −14 , F -test).

Their p values according to the GTEx data by the same selective expression measure (the proposed robust-regression z -score) were also highly significant based on the transcript-level selective expression, p = 1.5E−14 and 9.4E−12, respectively.

The most associated SNP, AX_91849634, was found on chromosome 3 with a highly significant p -value of ≤1.53 × 10 −14 .

Consistent identification of TGs across both sub-regions was observed, supported by highly significant overlaps for both upregulated (Hypergeometric test p = 1.6e-14) and downregulated ( p = 5.0e-17) genes, thereby underscoring the robustness of SCILD’s inference (Fig. 6i , Supplementary Table 3 ).

A highly significant relationship ( p = 1.61 × 10 −14 / p = 0.00, Table 6 ) was found between the P. minimum abundance estimates derived from amplicon sequencing data and the P. minimum -specific qPCR, while the relationships between microscope counts and qPCR and microscope counts and amplicon sequencing were not significant ( p > 0.05, Table 6 ).

Gene-based association analysis revealed a highly significant overlap between the two studies, with 15 shared genes among the 61 genes identified as significant in our GWAS (Supplementary Data 3 ; hypergeometric test P = 1.63 × 10 −14 ).

In contrast, the correlation between CD4 + and CD8 + T cell responses was highly significant in aggregate (R = 0.6756; p = 1.70 × 10 −14 ; Figure 2 F) and was significant for each of the individual antigen comparisons ( Figures 2 G–2I).