“highly significant”

Further inspection of GO revealed that this was due to the highly significant overrepresentation of genes for mitochondrial proteins (GO:0005739, P = 5 × 10 -15 ).

There was a highly significant association between childhood emotional abuse and NR3C1 methylation ( b =1.06; P =5.11 × 10 −15 ) showing that emotionally abused subjects had higher methylation status (0.135 (s.d.=0.03)) than non-emotionally abused subjects (0.098 (s.d.=0.03); Supplementary Figure S1 ).

Double-labelling with antibodies to Smo and to acetylated tubulin (which marks stable microtubules found in cilia) revealed a highly significant accumulation of Smo in the cilia of NIH-3T3 cells upon addition of ShhN ( Fig. 6 B,G; χ 2 =61.19, d.f.=1, n =157 cells, P =5.16×10 −15 ) whereas, in the absence of ShhN, cilia are largely devoid of Smo ( Fig. 6 A,G) ( Rohatgi et al., 2007 ).

3 C and F ), and in the full dataset, it remains highly significant even if interface size is included as a covariate with P = 5.9e −15 for the full dataset and P = 0.27 for the human dataset in an analysis of covariance (ANCOVA).

Notably, highly significant GO terms included skeletal system development (p = 6.1e-15), collagen fibril organization (p = 1.5e-15), extracellular matrix organization (p = 5.8e-13), and roof of mouth development (p = 4.7e-13).

We found that the sep-1(ts) mutant grown at permissive temperature showed a highly significant reduction in the number of apoptotic corpses (average of 2.4 ± 1.2 corpses; n = 53; p = 6.4 × 10 −15 ) at the “comma” stage of embryogenesis compared to that in wild type (N2) embryos (average of 4.4 ± 1.2; n = 121; Fig. 1B ).

The overall regression was found to be highly significant (R 2 = 0.641, F(7680) = 173.2, p < 6.4 × 10 −15 ).

This optimal model predicted PPB fraction in diet negatively affecting FCR ( p = 4 × 10 −7 , fraction of variance 0.12) with a highly significant interaction between time*diet type ( p = 7 × 10 −15 , fraction of variance 0.6).

Welch’s test confirmed a highly significant difference in mean pressure between groups, with higher values observed during intramuscular infusion, mean difference = 0.1430, t = 11.5990, p = 7.22 × 10 −15 , 95% CI: [0.1181, 0.1679].

First, as previously reported for various eukaryotes [ 63 , 64 ] most introns were inserted in phase 0 (40.2% of all introns) or phase 1 (38%), with a highly significant underrepresentation of intron insertions in phase 2 (21.8%; c 2 = 64.68, P = 8.98e -15 ; Figure 2a ).

Inversely, a statistically highly significant DEHP-induced decreased reads numbers (p = 9*10 −15 ) was observed in Tmem125 promoter region in MBDseq experiment in C57BL/6J controls (19.8±3.9) compared with DEHP300 (0.9±3.9%), ( Fig 5B ), consistent with a DEHP-induced decreased methylation levels recorded in pyrosequencing experiment in CpG 1 although not statistically significant (p = 0.7) in C57BL/6J controls (69±4%) compared to DEHP300 (65±10%), ( Fig 5C ).

However, for the Japanese cohorts, the difference between females and males was highly significant in the discovery stage ( P = 9.47E−15) and replication stage ( P = 2.71E−14) (Supplementary Table 2).

In contrast, the P3 tau peptide (residues 25-44) was less correlated to immunoassay measurements (cor = 0.78), yet still highly significant (p = 9.73e−15).

By Fisher's exact test, this enrichment is highly significant ( p -value = 1 × 10 −14 ) in comparison to the global data in which oxidation represents <5% of observed modifications ( Fig. 2 D ).

For the two metrics, the difference in performance is highly significant between each pair of models (p < 10 −14 ).

The overlap (25%, 57 genes) between the S2 cell screen (227 genes identified; Table S6 ) and our genome-wide study on Kc 167 cells (526 genes identified) was highly significant ( p < 1e −14 , Wilcox test).

PERMDISP analyses revealed significant within‐group variability at both class and ASV levels (bacteria: F = 8.98, p < 0.001; fungi: F = 7.59, p = 0.014; bacterial ASVs: F = 67.93, p = 0.000; fungal ASVs: F = 10.12, p < 0.001), while posthoc PERMANOVA confirmed highly significant temporal shifts, particularly in fungal classes and ASVs ( p < 1 × 10 −14 ) (Tables S2 and S3 ).

These contrasting trajectories were supported by statistical analyses: in cluster 1, differences between batches emerged as early as 2 hpi and remained highly significant thereafter ( P <1×10 −14 at 24 hpi); in cluster 2, divergence became significant from 8 hpi onward, with very big differences at 18 hpi and 24 hpi ( P <1×10 −10 and P <1×10 −65 , respectively); and in cluster 3, batches remained comparable until a pronounced difference appeared at 24 hpi ( P <1×10 −10 ) ( Fig. 4 ).

The results demonstrate a highly significant association between resistance and each of the five SNP markers tested from 10.01 to 10.63 Mb on chromosome 27 ( P < 10 –14 for each marker, SI Appendix , Table S4 ).

all β m being equal), which led to a highly significant deterioration of the likelihood function ( P value <10 −14 ).

A correlation analysis of the Spearman rho statistics between the two clusters is highly significant (rho = 0.39, p < 10 -14 ; using newborns declared as only one race, N = 162, rho = 0.41, p < 10 -14 ), indicating that similar trends exist in both groups.

Of the 871 SNPs with a C2 value above 60 (corresponding to a highly significant association, P < 10 −14 ), 867 were located in the middle of the X chromosome.

Focusing on the 1 Mb region surrounding each gene (and correcting for cancer type and CNA), 82 genes with FDR < 10% for each dataset overlapped between both results sets, a highly significant overlap ( p < 1E−14, one-sided Fisher’s exact test, Fig. 2 d).

HMGCR, although not listed as top five key drivers, was a highly significant key driver ( P < 10 −14 ).

This enrichment was highly significant ( P < 10 −14 , Fisher's exact test), suggesting that super-enhancers may indeed drive the high expression of numerous key EMT genes.