“highly significant”

This lead to the discovery of a highly significant association with the TNFSF15 gene, p = 1.71 × 10 -14 in a large replication sample.

As expected, the Nrf2/Keap1 pathway genes were highly significant (p = 1.8×10 −14 ).

The association was highly significant for white mothers ( P =1.8 × 10 −14 ) and for non-white mothers ( P =1.5 × 10 −6 ; Table 1 ).

Of these, 31 genes appeared in both lists, with the change occurring in the same direction, a highly significant convergence (Fisher Exact test p = 1.9 × 10 − 14 ; Fig. 1 a).

Venn diagram analysis identified 1,574 overlapping candidates that were both differentially expressed and differentially methylated ( Figure 4D ), a highly significant overlap (P < 1.9×10 −14 ).

Two linkage blocks within the Waxy locus (5034 bp in length) reflected an unusual LD decay within the gene, and the first block contained a highly significant T→G splice variant at 1 765 761 bp (−log( p ) = 13.72, β = −0.74) lying in 5′end of intron 1 (LOC_Os06g04200.1) (Figures 3 a and S4 a,b).

The multivariate analysis demonstrated that FH expression retained a highly significant effect on the angiogenesis score ( p = 1.97 × 10 −14 ), independent of age, tumor size, or molecular subtype. 3.3.

BS and TCB did not differ significantly among years (BS: χ 2 = 1.0, df = 6, P = 0.9847; TCB: χ 2 = 0.3, df = 8, P = 1), whereas ST showed a highly significant year effect (χ 2 = 63.1, df = 2, P = 1.984 × 10 −14 ).

We subjected the top 200 variant genes to GO (gene ontology) term analysis and found a highly significant over-representation of terms such as spermatogenesis ( p = 2E−14), mitosis ( p = 5E−6) and meiosis ( p = 1E−3).

The over-representation of human clinical isolates in the C clade was highly significant (P = 2.001×10 −14 , Fisher's exact test), and of the remaining 13 clinical isolates nine segregated within the E clade and four in the A clade.

Results: Logistic regression analysis showed a highly significant effect of the haplotype ranks in the outcome of a search in BMDW (p=2.25e-14).

Only one locus, IL23R , demonstrated true independence of the psoriasis SNP; the PsA-associated SNP rs12044149 remained highly significant ( P = 2.4×10 −14 ) after conditioning on the psoriasis SNP, rs9988642, and the addition of rs9988642 did not improve the model fit with LRT ( P = 0.21).

This polymorphism showed a highly significant risk effect on fibrogenesis, with an OR of 9.2 in the NAFLD/MASLD cohort ( p = 2.7 × 10 −14 ) [ 13 ].

The difference was highly significant (ANOVA F = 49.74, p = 2.7 × 10−14) and clinically meaningful, reflecting a reduction of nearly three days with earlier NPWT initiation (Table 1 , Figure 1 ).

This difference was further confirmed by a Mann–Whitney U test with continuity correction, which demonstrated a highly significant difference in absorbance distributions between the two strains ( W = 36,316, p = 2.846 × 10 −14 ).

This number suggests a highly significant association between UCSs and AS-NMD (Fisher’s exact test, P = 2.9 × 10 −14 ).

A notable example was the highly significant cASE observed in SLC30A8 (rs11558471; p = 2.9 × 10 −14 ), which showed colocalization with a well-established T2D-associated variant ( Figures 5F and 5G ; Table S5 ) for which there was no eQTL colocalization.

6 B ), along with the highly significant positive correlation (Pearson's correlation, r = 0.98; p = 3.1 × 10 −14 ; N = 19) between them, confirms the model's reliability as a KE estimator for any trajectory defined in either the hand space or the joint space, within the context of the current 2D movement setup.

The three-way interaction involving time as modelled by the B-splines, genotype and treatment was found to be highly significant ( P = 3.267e −14 ).

A GWAS for LSK cells revealed several suggestively associated loci, including those on chromosomes 2, 4, 6, and 18, as well as a highly significant (p = 3.7 × 10 −14 ) locus on chromosome 15 ( Figure 2 B; Table 1 ), where the lead SNP (rs31675052) is located approximately 100 kb downstream of Ly6f ( Figure 3 B).

A highly significant correlation was observed between SETD2 and H3K36me3 immunohistochemical staining ( P =3.8e-14, Cochran-Armitage test, Supplementary Figure S3a ), suggesting that absence of H3K36me3 staining is a good surrogate for SETD2 loss-of-function. 8 DNA damage was assessed by staining for phosphorylated his

For T1D, the white UK Biobank British PRS models was highly significant ( P = 3.8 × 10 −14 ) with outstanding predictive performance in white British ancestry; however, the predictive performance was significantly worse when transferred to individuals of African or South Asian ancestry.

HG was also highly significant ( p = 3.841 × 10 −14 ).

For example, we find that co‐regulation of transcripts and proteins from closeby genes is more common than for random protein pairs (Fig 1 B), and this enrichment is highly significant (3% versus 0.4%, P < 4 × 10 −14 ).

While these showed highly significant association ( p = 4.05×10 −14 for both markers) in the control group, in the temperature treated group neither marker was significantly associated after correction for multiple testing ( p = 0.039 for both markers).