“highly significant”

SNR Analysis ( Figure 4 ) : The repeated-measures ANOVA on IMU SNR revealed a highly significant main effect of filter type ( F 3,126 = 31.69 , p = 2.47 × 10 − 15 , η p 2 = 0.430 ) .

Indeed, the upstream regulator with the most highly significant association with the ISO-regulated gene cohort was determined through Ingenuity analysis to be CREB (p-value = 2.52E-15; z-score for activation = 4.157), confirming that transcriptome analysis of the cardiac RNA samples detected predicted and experimentally observed responses to ISO stimulation.

Interestingly, these SNP numbers are highly significant when compared to any random SNP set intersection with the GWAS catalog ( p -value < 2.537 × 10 −15 ).

Remarkably, functional analysis of HIF1A targets in the category of biological process showed highly significant enrichment of the GO terms response to unfolded protein ( P < 2.6∗10 -15 ), regulation of cellular response to stress ( P < 2.1∗10 -13 ), and protein folding ( P < 3.0∗10 -13 ) ( Figure 3 B , Supplementary Table 6 ).

Two-way ANOVA revealed highly significant main effects of both FSC gate (Df = 5, F = 20.06, p = 2.7e-15) and buffer (Df = 2, F = 20.14, p = 1.8e-8) as well as a significant interaction (Df = 10, F = 2.78, p = 0.004).

The p value of the network was highly significant ( p = 2.75 × 10 −15 ), suggesting significantly more interactions than expected.

The enrichment in deleterious NFKB1 variants of patients with CVID was selective and highly significant (P = 2.78 × 10 −15 ).

18 (−6.32 × 10 −16 ; bp 10993468) There were three other highly significant SNPs ( p < 3 × 10 −15 ) in chr. 4 (bp 85884362 to 85884367; solutions 2.167).

Our gene prioritization approach identified seven of 16 mtDNA depletion genes (Supplemental Table 13), consistent with a highly significant enrichment (one-sided p = 3.09 × 10 –15 ).

2014 ) confirmed a highly significant and consistent down-regulation of these genes in PRANCR -depleted keratinocytes ( P -value = 3.2 × 10 −15 ) ( Fig. 5 E).

Comparing all the data with respect to the 0 baseline, 169 mRNA were higher in BA but more than double that were higher in CH (345), a highly significant deviation from the null expectation of 50:50 equilibrium ( P =3.21 e −15 ; binomial test statistic).

However, our reanalysis revealed a highly significant difference (p = 3.3e −15 ) using the same statistical test as in 1 due to the numerous, large LPF on mysticete palates (Fig. 3 b–f, Fig.

A highly significant difference was observed between the two study areas ( p = 3.4 × 10 −15 ), and between the dry and wet seasons ( p = 0.005).

a sample-wide average of 0.262 (± 0.140) a highly significant difference (Mann-Whitney U Test, p -value = 3.5 × 10 −15 ).

The detected PKD2 variant is absent from the GnomAD and ClinVar databases, but we found its association with CKD highly significant (OR > 1000, p = 3.7 × 10 −15 ).

Considering our head (252 genes) and body (1,940 genes) datasets separately, and assuming 14,000 total genes in the Drosophila genome, the number of genes that intersect between our study and three or more other sets of age-related genes is highly significant (all p -values < 3.7 × 10 −15 ).

Detailed analyses of the gene expression network using publically-available ChIP-seq data ( http://genome.ucsc.edu/ENCODE/analyses ) revealed that there was a highly significant overrepresentation ( p = 3.8E−15) of MYC binding at the promoter regions among the positively correlated genes (29 of the 35 positively correlated genes), in relation to the negatively correlated genes (6 of the 67 genes) (Supporting Information Tables S3 and S4 ).

Replicates had highly significant Spearman rank correlation coefficients of 0.74–0.94 ( p = 4 × 10 −15 to 3 × 10 −24 ) per pair.

We found a highly significant proportion of RasD-dependent genes (36 out of 45; hypergeometric test; p = 4 × 10 −15 ) were also affected by nutritional history (>1.5 × increase or decrease in expression).

Early-onset PE had two highly significant gene modules: the yellow module (r = 0.73, p = 4e-15) with 112 DEGs enriched in biological processes related to gonadotrophin secretion and lipid storage, and the black module (r = −0.55, p = 5e-08) with 47 DEGs significantly enriched in chronic inflammation responses.

Indeed, we identified a highly significant QTL (-log 10 ( P -value) = 14.36) on chr10 across the 3 phenotypic datasets for Tuber Shape, which was detected both with SNP and haplotag markers ( Fig. 7 , Supplementary File 9 ).

Despite the spread attributable to differences in etiology, the association between EES groups appears highly significant, with Fisher’s exact test p—value = 4.4 × 10 −15 .

Comparing the number of diagnostic transitions observed 5′ and 3′ of the respective preferred crosslinking site, we found highly significant differences in CSD and ZKD crosslinking patterns (ZKD p = 4.7e-15; CSD p = 4.9e-06) ( Fig. 4D ).

This was shown by way of a simple one sample t-test, which for control plants indicated the distribution of response ratio across samples was not significantly different to 1 (theoretical mean for a distribution based on plants with no CO 2 response) at p < 0.05, whereas deviation from this limit among test plants was highly significant (p = 4.72e -15 ) ( S4 Fig ).

Because the correlation between the two ROIs was positive in every subject, the group-level statistic was highly significant (sign test, p < 5 x 10 −15 ).