“highly significant”

We observed a highly significant increase in DFI with increasing age ( ρ = 0.57; p = 1.04 × 10 −15 ; Figure 1b ).

The eGWAS peak SNP was detected approximately 9 kb upstream of OsENT1 with a highly significant signal (− log P = 14.97) and was located within 50 kb of the GWAS peak SNP responsible for NRT_L (Fig. 3 A).

Results for lung cancer overall are less significant after PC adjustment, but there is still a highly significant result for the ATM −2307F association in LUAD ( P = 1.18 × 10 −15 for discovery and P = 2.22 × 10 −3 for replication (Table 1 ).

We found, for H3K4me1, a highly significant enrichment for blood u-tDMRs (mean: 9.7; P -value = 1.2 × 10 −15 t-test) and liver f-tDMRs (mean: 9.3; P -value <2.2 × 10 −16 ; t-test for regions with methylation difference <0).

[ 12 ] also showed a strong and highly significant association between SMPD1 variants with ≥ 56% loss of enzymatic activity and PD risk (OR 2.24, p = 1.25 × 10 -15 ).

When we tested the association between SOX2 positivity and RAD51 expression, we found it to be highly significant (p = 1.28 × 10 −15 ), suggesting a correlation between RAD51 expression and the putative self-renewing fraction ( Figure 1 F).

All loci produced highly significant linear regression models (maximum P -value = 1.3 × 10 −15 , minimum R 2 = 0.11).

the effect was much stronger than that of the two individual metabolites (Table 4 , ESM Table 19 ; both p ≥ 2.2 × 10 −16 , p gain = 2.2 × 10 11 ). Fasting pairwise metabolite ratios at baseline and incident type 2 diabetes Meta-analysis of the Cox regression results in two independent prospective studies (910 individuals with incident type 2 diabetes and 3367 control participants), with adjustment as shown in ESM Table 10 , shows a highly significant association between the ratio of valine to PC ae C32:2 and type 2 diabetes susceptibility (Table 5 ; HR Val_PC ae C32:2 1.57 [β 0.45 ± 0.06], p = 1.3 × 10 −15 ; the results for the crude models are shown in ESM Table 20 ).

Three highly significant pathways were identified by the Reactome analysis of these protein clusters: The citrate (TCA) cycle pathway ( p = 1.33 × 10 −15 and FDR = 3.46 × 10 −14 ), the mRNA metabolism/catabolism pathway ( p = 7.96 × 10 −8 and FDR = 3.60 × 10 −6 ), and the unfolded protein response pathway (UPR; p = 2.04 × 10 −13 and FDR = 1.35 × 10 −11 ) ( Figure 9 d). 3.3.

There was also a highly significant relationship between gender and the number of English-language publications (Kruskal–Wallis chi-squared = 68.37, p < 1.42 × 10 −15 ) and between disciplines and the number of English-language publications (Kruskal–Wallis chi-squared = 29.45, p < 6.35 × 10 −6 ).

Fisher’s exact test demonstrated highly significant enrichment of current FDA-approved psoriasis biologics at both D1 ( Figure 2 d) and D2 (data not shown) ( GSE54456 : P = 1.42E-15 and 9.62E-7, respectively; GSE121212 : P = 5.13E-12 and 1.56E-6, respectively).

On the contrary we found a mild (1.98%) but highly significant ( P -value = 1.5 × 10 −15 , paired t -test) decrease in the average occupancy at nucleosome +1 in AGO2 knock-down cells (data not shown).

This difference was particularly marked in the aortic arch, where 72% of aneurysms were saccular, compared to the predominance of fusiform aneurysms in other regions of the aorta, a highly significant difference ( p = 1.57 × 10 −15 ).

Cross-sectional association of TFMs and thyroid functional status with eGFR Table 2 shows the cross-sectional associations of various thyroid traits on eGFR (mL/min/1.73 m 2 ). For TFMs added singularly to the regression model, FT3 (pmol/L) showed a highly significant positive association with eGFR (per 1 pmol/L increase of FT3, eGFR was 2.99 mL/min/1.73 m 2 higher; P = 1.6e–15).

Upstream regulators identified in the model included a highly significant activation of the rapamacyn-insensitive companion of mTOR (RICTOR) by Meth exposure ( p = 1.68 × 10 −15 ), and disorders assigned to cancer ( p = 3.2 × 10 −11 ), organismal injuries ( p = 3.2 × 10 −11 ), endocrine system disorders ( p = 8.83 × 10 −11 ), and metabolic disease ( p = 4.3 × 10 −9 ).

Our analyses showed a highly significant increase in effect size to develop childhood maltreatment across PRS quantiles in the PGC1.5 target sample, with a variance explained of r 2 = 0.0025 ( p = 1.8 × 10 −15 ).

Of these genes, 224 were differentially expressed in common among the two MR diets ( Figure 3 G), resulting in a highly significant overlap (p < 1.9 × 10 −15 , hypergeometric test).

Multiple Regression Analysis Multiple regression analysis yielded an overall highly significant result ( F = 7.97, df = 13,1154, p = 1.96 × 10 −15 , multiple R 2 = 0.082).

Upon analyzing the overlap between differential ATAC-seq and differential MyoD binding, we observed a total overlap of 253 differential peaks, which represents a highly significant portion of total differential ATAC-seq and MyoD peaks ( P = 2e-15) (Fig. 3g ), suggesting that Matr3 depletion simultaneously perturbs open chromatin regions and MyoD binding.

Indeed, we found a mild yet highly significant correlation between changes in gene expression in Chaserr –/– mEFs and the distance to the TTS of the closest tandem upstream gene (Spearman R = 0.2, P < 2 × 10 −15 ), with the effect observed mostly when the distance was shorter than ~6 kb (Fig. 4e ).

The highly significant uncertainty coefficients (adult retina: U = 0.34, p = 2 × 10 −15 ; developed organoid: U = 0.25, p = 1 × 10 −12 ) suggest correspondence between the transcriptome-based cell types and known marker-defined cell types.

The difference between the species was highly significant ( p = 2.1 × 10 −15 , t -test).

This proportion is smaller than the 11/14 match observed for the actin gene family ( Supplementary Figure S2 ), but is still highly significant ( P = 2.2 × 10 −15 , see ‘Materials and Methods’ section).

This enrichment is highly significant ( P = 2.2 × 10 −15 ), and when the direction and magnitude of gene expression changes in our CB19 data or the previously published doxorubicin treatment were compared with each other, the correlation was also highly significant ( P = 1.4 × 10 −14 ), indicating that both p53-activated and p53-repressed genes change in similar directions and magnitudes in CB19-treated cells and doxorubicin-treated cells ( Fig. 7A ).

The probability of this overlap is highly significant, p < 2.270e-15.