Barely Significant
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“did not reach statistical significance”

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After age stratification, in participants younger than 60 years, we found that the association between often playing computer games and a lower risk of ACP did not reach statistical significance (HR 0.393, 95% CI 0.175-0.844; P =.02; Table S12 in Multimedia Appendix 1 ).
However, the associations for the vmPFC and left anterior insula did not reach statistical significance (pairwise correlations: left striatum, r = − 0.36, p = 0.02; right striatum, r = − 0.35, p = 0.03; left anterior insula, r = − 0.19, p = 0.23; right anterior insula, r = − 0.35, p = 0.02; vmPFC, r = − 0.22, p = 0.12).
1 A and graphical abstract), which did not reach statistical significance, but a 19% reduction (RR 0.81; 95% CI: 0.69 – 0.95, p = 0.02) when the analysis was restricted to 14 days from randomisation (5/11 trials, 1329 patients) ( Fig. 1 B).
LAG-3 levels were also elevated in total CD3+ T lymphocytes and CD8+ effector T cells, but it did not reach statistical significance in CD4+ T cells (MFI: 213.8 ± 16.7 vs. 151.3 ± 8.3, p = 0.02, 290.1 ± 23.5 vs. 188.7 ± 14.2, p = 0.005 and 176.7 ± 17.78 vs. 132.9 ± 6.3, p = ns, respectively) ( Figure 4 A,D).
AdAg85A vaccine i.n and i.m boosting to BCG-immunized animals further significantly enhanced it to 467 and 412 days, respectively although the differences between BCG and BCG/Ad i.m groups did not reach statistical significance ( Fig. 5 ; p = 0.02 BCG/Ad i.n compared to BCG alone; p = 0.12 BCG/Ad i.m compared to BCG alone).
This outcome, whose individual components did not reach statistical significance, occurred in 35.5% of patients on treatment vs. 38.5% in the placebo group [relative risk (RR), 0.90; 95% confidence interval (CI), 0.82–0.98; P = 0.02]; 16.4% of patients on treatment and 17.5% of patients in the placebo arm died of cardiovascular causes (RR, 0.93; 95% CI, 0.81 to 1.06); 27.4% of patients on treatment and 29.6% in the placebo group were hospitalized for HF (RR, 0.90; 95% CI, 0.81–1.00).
Heart failure therapy: the fifth card.
Eur Heart J Suppl · 2023 · PMC10120986
After adjusting for age and smoking status, flicker-stimulated retinal arteriolar calibre change from baseline was associated with diabetes mellitus ( β = − 0.80, p < 0.0001) and flicker-stimulated venular calibre change from baseline ( β = 0.34, p = 0.0008), but this association did not reach statistical significance with reactive hyperaemia index ( β = 0.22, p = 0.02).
46 Although the pooled effect size (Hedges’ g=0.07, 95% confidence interval −0.08 to 0.22, P=0.360) was small and did not reach statistical significance, there was notable variation across intervention types—most prominently in dialectical therapy (g=0.361, P=0.021).
The analysis revealed significantly elevated levels of IL-6, IL-8, and IL-10 in the infection group, while IL-17A did not reach statistical significance as depicted in the heatmap (21.26 pg/ml vs. 7.63 pg/ml, p = 0.0210; 20.38 pg/ml vs. 13.02 pg/ml, p = 0.0050; 10.99 pg/ml vs. 5.63 pg/ml, p < 0.001, respectively, Figure 5 ).
However, evaluating intrapatient change in radiolucent line width, the tobacco nonuser group had more radiolucent lines resolve by the latest follow-up in nearly all radiographic zones, although most differences did not reach statistical significance, except for anteroposterior zone 1 (−31% vs −19%, P = .022).