Like previously reported 30 , 31 , α-diversity analyses of 16 S data showed a clearly significant reduction in the diversity, evenness, and richness metrics associated with CD and UC samples compared to control samples (Supplementary Fig. 4b ).
Four proteins that were clearly significant at time point 1 but that did not pass the significance threshold at time point 2, and are of particular interest were FN1 ( P -value at t1: 4.82 × 10 −3 ; t2: 1.61 × 10 −1 ; t3: 4.37 × 10 −1 ), IGHA1 ( P -value at t1: 2.45 × 10 −3 ; t2: 1.21 × 10 −1 ; t3: 2.67 × 10 −1 ), IGHA2 ( P -value at t1: 1.11 × 10 −2 ; t2: 7.9 × 10 −1 ; t3: 1.25 × 10 −1 ), and KNG1 ( P -value at t1: 2.67 × 10 −3 ; t2: 8.29 × 10 −2 ; t3: 5.68 × 10 −1 ).
Additionally, intracellular production of ROS increased sometime after 2 h (clearly significant at the 24 h timepoint), which may link to the induction of autophagy and cross talk between the intrinsic apoptotic pathways.
However, although the numbers of patients are limited, the association between the detection of the three proteins and prognostic is clearly significant (Fig. 3c ).
Consistently, a greater knockdown extent of ANXA5 led to more clearly significant suppressions on in vitro malignant property and metastasis ability of Hca-P cells.
In both sexes, a clearly significant inverse association was seen between adiponectin and MRI-quantified liver fat content ( Fig. 2 and Table 2 ).
The relationships between the specific lactose consumption rate and the dilution rate were linear and clearly significant under both anaerobic and respiration-permissive conditions (observed F -test statistic F obs, AN = 656 > F 0.001,1,10 = 21 and F obs, RES = 1,072 > F 0.001,1,9 = 23, respectively), indicating that the maintenance coefficient was independent of the specific growth rate in both cases ( Fig. 4A ).
We observed a clearly significant reduction (~50%) in the transcript levels of COX1 in both KO cell lines.
The difference in GATA3 levels between control and PLC inhibitor treated embryos is small, but clearly significant.
While our data suggest an unfavorable survival outcome; we were not able to demonstrate a clearly significant prognostic correlation between high levels of sE-cad-positive exosomes and either histological subtypes or FIGO stages.
There is a clearly significant correlation with yield (r = −0.95), pH (r = −0.88) and Ntot (r = 0.71) on the PC2 axis.
MAG-SGB-based gene prevalences exhibited substantial and clearly significant positive correlations between environments, i.e., a gene that was widespread in species from one environment also tended to be widespread in species from other environments (Pearson r ≥ 0.840 and P < 0.001 for all environment pairs, Supplemental Fig.
Georgia’s ‘soft’ infrastructure for trade facilitation and logistics compares well with others in the Central Asia and South Caucasus region, but there are clearly significant gaps that need to be addressed (The World Bank 2020 ) 6 .
From model 2 , time differences (pre vs post weaning) were clearly significant, while treatment differences were barely significant.
The total length of all timeseries became 33 × 240 years, implying for inter-annual variations a lower bound of 2638 degrees of freedom for significance tests, and for decadal variations a lower bound of 607 degrees of freedom (we are not interested to determine the exact significance bound which has to be estimated by a suite of Monte Carlo simulations, as all relevant results are clearly significant and supported by physical understanding).
The power of the meta-analysis is very clear in that the confidence intervals for many of the outcome metrics from individual studies overlap 0, yet most of the important outcomes are clearly significant when all of the data is considered.
Increase of TBX5, HAND1 and HCN4 is observed at D5 but clearly significant at D10.
Benchmarking the Impact on Enrichment Methods Overrepresentation Analysis As illustrated by our results, pathway analogs from different pathway databases in several cases showed clearly significant rank differences ( Figure 3 ).
There are clearly significant differences between molecular characteristics of the well-characterized anti-PD-1 mAbs.
The phosphate buffer data cannot be simulated with the k 3 values obtained for the MES buffer data, indicating that this difference is clearly significant.
Pleiotropic defects are clearly significant for α/β lobes of the MB, phenocopied by RNAi, and even stronger upon Dg overexpression, showing that proper levels/timing of Dg are critical for axon/brain development.
The clusters are clearly significant: The mean Kullback–Leibler divergence between density profiles within the same cluster is one to two orders of magnitude smaller than the mean divergence between density profiles in different clusters ( Fig. 3 B ), and the density profiles cannot be explained by local sequence composition ( SI Appendix , Fig.
Reductions in mRNA level of mitochondrial proteins are often fairly small, but are clearly significant as recent proteomic studies in worms and mammals have discovered matching reductions in the ETC, ATP synthase, the tricarboxylic acid cycle and mitochondrial ribosomal proteins (Gomez-Serrano et al. 2017 ; Liang et al. 2014 ; Nishtala et al. 2013 ; Ori et al. 2015 ; Stauch et al. 2015 ; Walther et al. 2015 ; Xu et al. 2016 ).
However, the physiological attributes themselves were in a clearly significant positive correlation because of their longitudinal identical vectors.
While a few research groups have failed to observe positive results from action video game training on cognitive abilities (Owen et al., 2010 ; Boot et al., 2013 ; Kundu et al., 2013 ), meta-analyses indicate a clearly significant overall effect in the medium to large range on the association between AVG and cognitive development (Latham et al., 2013 ; Powers et al., 2013 ; Toril, 2014 ; Wang et al., 2016 ).