Given that a large part of the reservoir in PWH receiving ART is established at initiation of treatment ( 18 ), the interruption of the integration step by InSTIs is clearly significant, differentiating this family from other antiretroviral drugs, with wide-ranging implications for the viral reservoir, particularly in terms of its size, even years after initiation of ART ( 19 ).
46 All of these different parameters were clearly significant in interpreting a study 47 of the structural evolution of mesostructured PtRu NPs generated within a lyotropic liquid-crystalline template.
This translated into clearly significant relationships between the decreased level of glutamate and negative, cognitive, and general symptoms obtained in this endophenotype, and a significantly smaller relationship with positive symptoms.
The fact that the REC effect with the vocal-visual R-E mapping was clearly significant in Experiment 1 but not in Experiment 2 might be due to the lengthened R-E delay in Experiment 2 relative to Experiment 1.
The effect of VEGF was evident even at day 1 (but not statistically significant) but clearly significant by days 4 and 7.
The difference in GATA3 levels between control and PLC inhibitor treated embryos is small, but clearly significant.
There are clearly significant differences between molecular characteristics of the well-characterized anti-PD-1 mAbs.
The phosphate buffer data cannot be simulated with the k 3 values obtained for the MES buffer data, indicating that this difference is clearly significant.
We have to acknowledge, however, that overall no association between cereal fibre and risk for type 2 diabetes was detected in the EPIC-InterAct study, while such an association was observed in many other prospective cohort studies resulting in a clearly significant protective effect in a meta-analysis [ 28 ].
Of the respondents, slightly more than one third found the education clearly significant from the point of view of their professional development, and two thirds found it somewhat significant.
Additionally, intracellular production of ROS increased sometime after 2 h (clearly significant at the 24 h timepoint), which may link to the induction of autophagy and cross talk between the intrinsic apoptotic pathways.
The inappropriate use of antibiotics in human has been suggested as the cause of this alarming prevalence in the community, however, clearly significant associations between the presence of ESBL-E and antibiotic use is missing [ 21 , 22 ].
These were trends rather than clearly significant differences probably due to the limited number of studies available for inclusion.
While intragenic and overlapping miRNAs showed a clearly significant probability to target their host genes, near-gene miRNAs exhibited a significantly lower target probability for genes in their direct vicinity as compared to intragenic miRNAs for their host genes.
4 f) revealed a reduced Ca 2+ transfer in HFHSD cardiomyocytes, becoming clearly significant at 2 Hz (Fig. 4 g), and confirmed by a significant decrease in the area under curve (SD: 67.3 [45.7, 88.7] vs HFHSD: 45.4 [26.8, 58.3] a.u, n = 26–34 cells from N = 3 mice/group, p < 0.05).
There is a clearly significant correlation with yield (r = −0.95), pH (r = −0.88) and Ntot (r = 0.71) on the PC2 axis.
The power of the meta-analysis is very clear in that the confidence intervals for many of the outcome metrics from individual studies overlap 0, yet most of the important outcomes are clearly significant when all of the data is considered.
However, the lower but still clearly significant decrease in cortical tissue stiffness at greater distances from the injury site (that is, 500–1,000 μm, corresponding to regions A′, C′ and D′ in Fig. 2 ), particularly in those regions containing myelinated fibres of the cingulum (regions medial to the scar, Fig. 3 and Supplementary Table 4 ), was mostly accompanied by an upregulation of glial intermediate filaments ( Fig. 5b, c and Supplementary Fig. 4b, c ).
However, this risk was clearly significant when students noticed that teachers smoke almost daily or daily.
Admittedly, the use of large datasets makes most analyses yield either clearly significant or non-significant results, due to the large sample sizes, thus making the distinction between the practical relevance or meaningful effect size important to consider (e.g., ‘smallest effect size of interest’; Lakens et al. 2018 ), rather than the statistical significance itself.
Except for the last period, moderate grazing intensity tended to be associated with the greatest effort in walking compared with the other grazing intensities, an effect which became clearly significant in 2017 ( Table 4 ).
Nevertheless, results showed clearly significant differences concerning delirium incidence in a propensity score matched cohort.
There are two possible explanations for this clearly significant tendency for negative returns following the government’s interventions, rooted in two different, but somewhat related, reasons.
As the doctors and medical providers highly recommended continuous hydration, effects of these recommendations were clearly significant in the patients’ diets.
Hypertriglyceridemia has been observed from the 4th week of a cafeteria diet in hamsters [ 25 ] and after 8 weeks in rats [ 36 ]; however, hypercholesterolemia needs a longer treatment time to show clearly significant increases—around 13 weeks of a cafeteria diet [ 16 ].