“borderline significance”

Third, the difference in the primary outcome of all-cause death reached only borderline significance after adjustment with propensity score matching, and there is a possibility that the results were only due to chance.

IL-6 showed significantly higher levels for the patients compared to the healthy controls ( p -value < 0.01); sgp130 levels were also higher in the patients but this difference reached only borderline significance ( p -value 0.049), whereas sIL-6R levels did not differ significantly.

Recently, a meta-analysis on 18,766 women with median follow-up 5.6 years showed that by using bisphosphonates including zoledronic acid, the reductions in recurrence (RR 0.·94, 95% CI 0.87–1.01; 2p=0.08), distant recurrence (0.92, 0.85–0.99; 2p=0.03), and breast cancer mortality (0.91, 0.83–0.99; 2p=0.04) were of only borderline significance, but the reduction in bone recurrence was more significant (0.83, 0.73–0·94; 2p=0.004).

This borderline significance is likely an artefact of a smaller sample, and as such, we treat the level of education as a meaningful predictor of DKAS-I scores here.

Many of these transferable GWA-identified signals were observed in the Kuwaiti cohort at borderline significance, suggestive of association.

We did find a borderline significance for a higher proportion of total MUFA in the TT compared with the AT genotype in the android depot ( Table 2 ).

In the first case (best possible result, Supplementary Table 3 ), borderline significance could be obtained between groups and for interaction term, but without any significant progression of proBNPage over time.

While single-point analyses show limited associations, haplotype analysis reveals borderline significance for the AA haplotype across -592C/A and -1082A/G markers ( Silva et al., 1992 ; Hollander, 2012 ; Farouk et al., 2010 ).

This outcome indicates a possible advantage of the intervention, although the borderline significance underscores the necessity for further rigorous clinical trials.

Given the small effect sizes, the borderline significance at baseline, and multiple comparisons, integration of these metrics into screening or diagnostic algorithms should await confirmation in larger, multicenter, prospective studies that include contemporaneous biochemical profiling and reproducibility assessments.

Final model The final multivariable model of characteristics independently associated with high frustration included younger age, higher stress, more hours worked per week (borderline significance), medicine subspecialty, and higher reported percentages of patients with psychosocial and substance abuse problems (Table 4 ).

However, to avoid the well-recognized biases associated with univariate screening (e.g., potential omission of important confounders with borderline significance, overfitting, and exaggerated effect estimates), we also forced clinically essential variables (e.g., age) into the multivariable model regardless of their univariate p -value, and we considered clinical relevance from prior literature as an additional criterion.

A second finding is that village inhabitants who spend a significant amount of time outside the village seem to have a lower risk for HAT infection (regular work outside village, having family members in neighbouring villages, visiting cattle market (borderline significance)) whereas activities involving presence in the village during the entire day (working in household as main occupation) appear to carry a higher risk of HAT.

The prevalence of severe hypertension differed at borderline significance among genotype groups for G482S and significantly for +2962A/G.

Although current smoking was not significantly associated with physical activity, the results did indicate a lower risk for insufficient activity (borderline significance).

The clinical stage at diagnosis was the only clinicopathologic feature associated with the LMR, while tumor invasion depth showed borderline significance.

Correlations with borderline significance were found between gender and HRV parameters, whereas diastolic blood pressure, total cholesterol or triglyceride levels and use of calcium channel blockers did not show any significant correlation with them ( Table 2 ).

To assess the impact of missing covariates, we applied multiple imputation for missing BMI, education, cigarette smoking status, exercise, walking, histories of hypertension and diabetes data using PROC MI and PROC MIANALYSE. All analyses were performed using SAS 9.4, and we determined when a two-tailed p -value was less than 0.05 as the statistical significance and 0.05-<0.10 as borderline significance.

Similarly, the borderline significance of MA over glucocorticoids (GC) in pain reduction (MD = −2.42, 95% CI: −4.89 to 0.05) aligns with evidence that GCs exert short-term anti-inflammatory effects, whereas MA’s stromal vascular fraction promotes tissue regeneration through paracrine signaling [ 33 ].

Borderline significance was detected when examining the groups based on the absence or presence of pulmonary involvement.

Data were then finally reviewed, and any datapoints with borderline significance that were based on population frequencies <0.25% were removed.

Although none of the individual studies reported statistically significant differences in serious toxicities between patients with UC and central tumors ( 9 , 12 , 13 , 15 , 41 ), considering the small patient number of individual studies and borderline significance found in our subgroup comparisons, we support the notion that applying SBRT for UC tumors carries a greater risk of fatal toxicities than does applying it for central tumors.

After controlling for potential confounding variables, low bone mineral density was significantly associated with a higher risk of mortality, and the low appendicular lean mass had borderline significance.

In both the results section of the abstract and the second paragraph of the long results section, the authors note that a reduction of bronchopulmonary dysplasia occurred with borderline significance in favour of the nasal continuous positive airway pressure (CPAP) group.

The protective effect in the present study had borderline significance.