[ 21 ] reported a decreased risk of breast cancer among European populations in the recessive model, with borderline significance (OR, 0.96, 95% CI, 0.92-1.00; OR, 0.90, 95% CI, 0.90-1.00, respectively), but not in Asians.
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“borderline significance”
In the literature
A study in Malawi on school-going children in the Cooking and Pneumonia sub-study found lower FVC z-scores in children with higher exposure households although this was a small difference with borderline significance (0.22 z-score), but not for any other lung parameters [ 71 ].
The second group of patients had a 50% higher risk of AKP, with borderline significance (PR = 1.5, CI: 1.0–2.3).
Attending training courses on the quality of endoscopy in the last 5 years was associated with better adherence to performance measures for both upper (OR 1.93, 95% CI: 0.94–3.94, p = 0.07) and lower (OR 1.96, 95% CI: 0.91–4.2, p = 0.08) GI endoscopy, with a borderline significance ( Tables 4 , 5 ).
Major surgery was associated with a significant increase in ALT levels at days 5 and 10 after the surgical procedure, whereas minor surgery was associated with a borderline significance at day 10 after surgery.
Further, PCE-exposed individuals were found to be at lower risk of overweight/obesity for three more items, with borderline significance.
Other differences with borderline significance in the CCR5 Δ32/wt genotype distribution included transmission route (16.1%, 11.8%, and 14.2% for homosexual, heterosexual and injection drug use (IDU) related transmissions, respectively, p = 0.07), female vs. male gender (9.7% and 15.7%, respectively, p = 0.08) and initiation of antiretroviral treatment (20.0% among treatment naive individuals vs. 13.0% among cART treated patients, p = 0.09).
Vietnamese mothers lacking confidence were more likely to feel that they were abusing their children, although this reached only borderline significance (5, 12%).
A borderline significance was observed for post-bronchodilator % predicted FEV1 with a difference in percentage points between the low and high vehicle density category of 11.4 percentage points.
Meanwhile, increases in SHBG and decreases in free testosterone showed borderline significance.
The IR of NMSC was 3.04 per 10,000 person-years in the DM cohort, which was 1.29 times higher than in the non-DM cohort with borderline significance.
Changes in M-MDSC proportion (p = 0.061) and TSH (p = 0.078) showed borderline significance ( Table 4 ).
In a follow-up validation study using two independent public datasets, the survival analyses also confirmed the conclusion, although Zhang's cohort just reach a borderline significance ( P log-rank = 0.015 and P log-rank = 0.088, Figures 2 H and 2 I) 39 , 40 .
On the other side, in the case of European cohorts, a borderline significance was observed with the same amount of egg consumption.
Therefore, despite the borderline significance, the interaction was further investigated.
The continuous risk of donor age increment on patient mortality was increased up to the 1st year (RR = 1.10, 1.12, and 1.15 at 90 days, 180 days, and 1 year, respectively), but declined to borderline significance at 3 and 5 years (RR = 1.10 and 1.08 at 3 and 5 years, respectively) ( Table 3 ).
A clinical trial with an expanded cohort would be instrumental to reaffirm the borderline significance observed in key parameters, including the Park score, RANO criteria, and the relationship between preoperative and postoperative tumor volume.
Elevated CRP levels did not significantly increase prescribing, except when no advice (C) could be given because the preliminary diagnosis and/or clinical indicators were lacking or unsure (borderline significance) (fully adjusted analysis: “no advice (C)”: aOR 1.82 (95% CI 1.01–3.27)) ( Figure 3 , Table 2 , Appendix 6 ).
However, some dimensions such as Personal Growth, Positive Relations, and Purpose in Life showed trends toward borderline significance in favor of female participants.
This association, however, diminished to borderline significance after adjusting for BMI.
Likewise, those seeking information several times a day (OR = 1.138, p < 0.001) and several times a week (OR = 1.108, p < 0.05 (borderline significance)) also exhibited significantly higher odds of holding such beliefs.
This borderline significance could be attributable to biological heterogeneity or limited statistical power, warranting further investigation in larger cohorts.
All statistically significant associations have a borderline significance level, which can most likely be explained by a small sample for this analysis.
The prevalence of meeting aerobic exercise guidelines was lower in cancer survivors, with a borderline significance.
For spina bifida, rates among Hispanics (PR: 0.64; 95% CI 0.56–0.74) declined 36% pre- to post-fortification and 34% among non-Hispanic white births (PR: 0.66 95% CI 0.60–0.72), but showed only borderline significance among non-Hispanic blacks (PR: 0.81; 95% CI 0.67–1.00) [ 73 ].