Barely Significant
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“borderline significance”

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In the literature

Also, as in previous studies, it is difficult to isolate the effect of smoking cessation alone, since smoking cessation was also associated with other characteristics that were of prognostic importance such as age, the type of index event, and (at a borderline significance level) previous vascular events.
This showed that reassortment rate was still significantly negatively correlated with d N /d S independent of the proportion of wild birds as host in all six internal segments (R: -0.79 to −0.44, P < 0.01; Additional file 2 : Table S3 column 5 and 7); and independently positively correlated with proportion of wild birds as host (R:-0.66 to −0.29, P < 0.07; Additional file 2 : Table S3 column 8 and 10) with borderline significance, thus both host and selective constraint are associated with reassortment rate.
However, when applying FDR correction for multiple testing, only galactinol (OR = 0.56; 95% CI: 0.40–0.78; p = 0.001; FDR = 0.075) and Pyrogallol (OR = 0.50; 95% CI: 0.32–0.77; p = 0.002; FDR = 0.104) retained borderline significance. All other metabolites lost statistical significance after FDR adjustment (FDR > 0.20).
Instead, GO terms ‘DNA or RNA binding’, p FDR = 1.97E–3; ‘unknown molecular function’, P FDR = 1.97E–3; ‘transferase activity’, P FDR = 2.6E–3; ‘transporter activity’, P FDR = 3.1E–3; ‘nucleic acid binding’, P FDR = 1.2E–2; ‘other binding’, P FDR = 1.2E–2, were obtained at borderline significance levels.
In the validation study [ 13 ], microarray data showed that high PITX2 methylation was significantly associated with early recurrence after prostatectomy in univariate analysis, and remained significant also in multivariate analysis together with Gleason score, tumor stage, and surgical margin status, whereas pre-operative PSA showed borderline significance.