Barely Significant
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“approached significance”

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approached significancep = 0.061.2× alpha
The direct effect of RFu on self-harm approached significance (path f : β = 0.11; p = 0.06), however, neither dimension of attachment insecurity significantly predicted RFu (path c : β = 0.11; p = 0.22; path d : β = 0.07; p = 0.36) or self-harm (path g : β = 0.02; p = 0.85; path h : β = 0.01; p = 0.90).
approached significanceP =0.061.2× alpha
However, when the sample was restricted to individuals who reported consuming alcohol within the 2 weeks preceding their scan ( n =31), the BD × AD interaction, signifying uniquely low levels of dACC glutamate/water in BD+AD (Cohen’s d for BD+AD vs HC=1.01), approached significance (F=3.83, P =0.06) and reached significance (F=4.21, P =0.05) once within-voxel gray matter/brain matter composition was statistically controlled; see Figure 2 .
approached significancep = 0.0601.2× alpha
a negative trendp = 0.0901.8× alphagold
In immunosuppressive treatment decisions, comorbidity burden showed a negative trend (β = −0.610, p = 0.090), suggesting reduced likelihood of therapy in patients with multiple comorbidities, while ANA positivity approached significance (β = 1.726, p = 0.060), indicating a possible increased propensity for treatment in this subgroup.