Although no one pathway was significantly enriched in the variant TP53 cohort over the wildtype cohort, KRAS signaling downregulation approached significance (freq = 15%; FDR = 0.09; Supplementary Fig.
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Results : Group*time interactions approached significance with large effect sizes on the vector of both dependent variables and in a univariate fashion on object control scores, but not locomotor scores.
None of the other comparisons between age groups approached significance (all p s > 0.446).
Some findings which approached significance should be considered for follow-up.
( 2012 ) and between-group differences for functioning and depression symptoms approached significance, in favour of the telephone condition (Kilbourne et al. , 2012 ).
While the difference in the duration of illness approached significance, it did not reach statistical significance.
Four of those analyses found no significant performance differences between participants with and without disabilities (Sellers et al., 2006 ; Ikegami et al., 2011 ; Oken et al., 2014 ; McCane et al., 2015 ), though a comparison of the highest difficulty level completed on a multi-level typing task approached significance for one study (Oken et al., 2014 ).
However, all three meta analyses were statistically non-significant, although the effects on emotional symptoms approached significance (ES = -0.47, 95% CI = -1.00 to 0.07).
Weight gain and feed intake were not compromised by reduced-CP diets with a numerical increase of 3.36% (3,197 versus 3,093 g/bird; P = 0.058) in feed intake, which closely approached significance.
25.9%, p = 0.017), which approached significance.
Instead, we found that the averaged spatial similarity across the −880 – −485 ms interval before the onset of the SFW (corresponding to 120–515 ms after the onset of SFW-1) remained larger for the within-pair sentences (R = 0.072 + /- 0.02) than the between-pair sentences (R = 0.063 + /- 0.03): t (25) = 1.81, p = 0.08 ( Figure 2—figure supplement 2 ), although in this subset analysis, the difference only approached significance due to the limited statistical power (on average there were only 40 within-pairs and 29 between-pairs after artifact rejection).
One found no difference between the interventional and control arms on total decisional conflict and decision-making types (i.e., uncertainty, informed, values, support, and effective), although total decisional conflict, and values and support decision-making approached significance (Schapira et al. 2019 ).
In addition, the presence of UPRORs was correlated with sizable decreases that approached significance in the Transfer (− 11 points, 95% CI − 30; 8.0), Child Satisfaction (-7.6 points, 95% CI − 25; 9.3), and Parental Satisfaction (− 11 points, 95% CI − 25; 3.9) domains.
The left temporal ROI approached significance ( P FDR =0.077).
The difference by sexual orientation approached significance, suggesting that gay couples were more likely than heterosexual couples to think it was important for their surrogate to have particular characteristics (gay couples = 85%, 35; heterosexual couples 68%, 52) [χ 2 (1) = 3.76, P =.07].
6 Association of this locus with sum of skinfolds, driven primarily by skinfold thickness at the triceps, approached significance in the cohort of 2-year olds, but this association was in the opposite direction to that observed in newborns.
One single VPA dose further reduced brain-specific RNA 13 C labeling to 1.15% (SD = 0.26), which closely approached significance by a “ P ” value of 0.072 using the more severe two-tailed “ t ” test.
Regression analysis confirmed that TXA administration had no independent association with platelet count, whereas the association with lower WBC approached significance but did not remain robust after adjustment (Table 4 ).
However, when looking at PD-L1 expression, comparing expression less than 1% or greater than or equal to 1% did not significantly impact pneumonitis events, but there were seven pneumonitis events (38.7%) at 1 year with PD-L1 expression less than 50% versus 2 pneumonitis events (10.5%) at 1 year with PD-L1 expression greater than or equal to 50% with a p value of 0.053 that approached significance.
The interaction (F = 2.78, p = 0.0678) and flatness differences approached significance, suggesting potential trends in group variability that warrant further study.
No factorial interaction approached significance.
In the early time-window, no main effects or interactions involving the critical condition factor reached or approached significance (all Fs < 2.3, P s > 0.12).
The effect of baseline TG on LDL-C appeared to reach significance (ie, the 95% CIs for the point estimates did not overlap for the two subgroups) in the ERN/LRPT alone group, and approached significance in the pooled SIMVA alone and pooled ERN/LRPT + SIMVA groups.
However, the predicted error values for TLV approached significance.
However, the labial alveolar bone height post-retraction (p = 0.061) approached significance, suggesting a trend towards differential bone remodeling, although the difference was not statistically significant.