“an overall trend”

The global prevalence of HUA has increased significantly in recent years, with an overall trend of increase and rejuvenation [ 5 ].

Further, the sheer number of activated pathways and upregulated markers associated with inflammation and immune system activation is indicative of an overall trend, despite the potential for false positives.

While this intensity metric was useful to observe an overall trend, the accumulation of these compounds in a few sites that we observed in FLIM is not discernable here.

Additionally, there was an overall trend of SAR reduction in Bangkok and central regions, where human and financial resources were traditionally concentrated, and increase in northeastern regions, where the resources were traditionally scarce, over the eight years [ 10 , 32 ].

In summary, (1) HDC can control the generation and development of cracks to a large extent, and the cracks generated under chloride salt erosion are mostly fine cracks, which can slow down the diffusion rate of chloride ions; (2) Cl − reduces the erosive effect of sulfate on concrete; (3) With the increase in the number of wet and dry cycles in the sulfate environment, the compressive strength of HDC shows an overall trend of increasing and then decreasing, and its resistance to sulfate erosion with wet and dry cycles is significantly better than that of plain concrete; (4) Increasing the concentration of sulfate solution gradually increases the rate of the loss of compressive strength of HDC, and its compressive strength is gradually reduced, which gradually reduces the durability and bearing capacity of highly ductile concrete under dry and wet cycles, and sulfate erosion is the joint result of physical and chemical effects on HDC. 4.2.

In the current study, the fMRI time points were divided into two halves, which revealed an overall trend of decreased functional connectivity for the 11 domain-specific links from the 1 st to the 2 nd half.

In all cases, an overall trend to increase virulence and infectivity along time can be observed in the time-series data ( Figs 3 and 4 ).

Other up-regulated genes such as SERPINB7 (Megsin), TM4SF1 (a member of the tetraspanin family), VGF (nerve growth factor inducible), and DKK1 (an inhibitor of WNT signaling) were preferentially increased at the high dose; At the late time point (72 h), gene expression changes were smaller compared to the 48 h time point, indicating an overall trend to return to levels found in the control group at low dose, but still up-regulated at high dose, as observed for GDF15 and CDNK1A.

Transect 4, located landward of the southern jetty is seen to have a more significant change than the other transects, with an overall trend of accretion.

Although we observed an overall trend, significance was not reached, which may be due to the high variability with this staining that contains medium Aγ peptidergic nociceptors and medium to large Aβ mechanoreceptors as well as large Aα proprioceptors ( Figure 6 A,B).

Thus, although there is an overall trend to increase in the hippocampus and entorhinal cortex, it is not possible to conclude that miRNA changes observed in plasma are related to those observed in the brain since they lack global statistical significance. miR-181c-5p has neuronal pentraxin 1 (NPTX1) and neuronal pentraxin receptor (NPTXR) as potential targets.

The comprehensive evaluation revealed significant variability in salt tolerance among the sorghum germplasm, with an overall trend of normal distribution.

Figure 1 presents an overall trend in terms of CED size in each group.

We also observed an overall trend toward down‐regulation among the d = 1 genes, shown as orange dots (Figure 3 b).

As the mechanistic rationale for limus-eluting platforms is well established, we focus on the comparative findings: within this network meta-analysis, SES demonstrated favorable outcomes across TLR, BR, and MI, although these advantages should be interpreted as part of an overall trend rather than conclusive statistical superiority.

Future predictions from various models and emission scenarios indicate that, despite differing migration directions, there is an overall trend of movement toward higher latitudes in the southeast.

An overall trend toward favorable patient survival was also observed in the polyclonal group.

The serial echocardiographic evaluations conducted in patients without preexisting structural heart disease demonstrate an overall trend towards an improved cardiac function and a reduced myocardial thickening at 1-year follow-up.

HPX levels in subject plasma showed an overall trend of lowered expression in those with active cirrhosis compared to controls, with a “bounce back” effect seen as the protein levels are somewhat restored to control levels in the HCC subjects.

In Argentina, diversity appeared to decrease between 1989–1999 and 2000–2012 before increasing again in 2013–2019, with an overall trend of increased pathotype diversity over time (Table 2 ).

Regarding disease severity, there was an overall trend toward a higher risk of death for those with severe or critical diseases throughout all periods, except for period V.

Third, while this study describes an overall trend in the CS rate, we observed notable annual fluctuation, including a more pronounced increase in 2023.

As shown in Figure 4 a, increasing curcumin concentration from 0 to 200 μM in the photosensitization treatment resulted in no significant change in botrydial concentration after 11 days incubation at 26 °C, although there was an overall trend of decreasing dihydrobotrydial ( Figure 4 b).

There was an overall trend of up-regulation of protein expression in blood taken from the transiently ischemic limb during the RIPC protocol and this increase in the number of up-regulated peptides was cumulative with each cycle of the IR of the limb.

Figure 6 presents the EEG spectrogram for frontal and posterior electrodes, showing an overall trend of higher oscillatory activity in low frequencies over time.