“an increasing trend”

As shown in Figure 4 a,f, Bcl-2 showed a decreasing trend after 6b administration, and the ratio between the Bax/Bcl-2 proteins showed an increasing trend, indicating that 6b possesses the effect of promoting apoptosis (*** p < 0.001).

There was an increasing trend from the low-risk to the high-risk groups ( p < 0.001, Cochran–Armitage trend test).

From the low level to the high level of the TyG index, both treated as continuous variable and categorical variable, the incidence of UIA growth and UIA growth events had an increasing trend ( P <0.001; Tables S2 and S3 ).

An increasing trend in mean HbA1c was found in healthy and high-risk hosts (healthy hosts, 0.07 ± 0.02% [ P < 0.001]; high-risk hosts, 0.10 ± 0.03% [ P < 0.001]; Table 2 ).

PRAL, NEAP and DAL score were significantly different in DAL quartiles, with an increasing trend (p < 0.001).

Through trend test analysis, the clozapine serum concentration showed an increasing trend with increasing drug dose ( p < 0.001), and the C/D ratio showed a decreasing trend with increasing daily drug dose ( p < 0.001) (Table 3 ).

Generally, we found an increasing trend concerning crude seropositivity with advancing age ( p < 0.001); however, differences were only significant when comparing the older age group 60–69 (5.2%; 95% confidence interval (CI) 4.5–5.9%) to the younger age group 20–29 (2.6%; 95%-CI 1.8–3.5%) (Table 1 ).

Results In 1236 saliva samples from 903 boys aged between 11 and 16 years, salivary androgens except DHEA exhibited an increasing trend with an advancing age (ANOVA, P < 0.001), with salivary testosterone and A4 concentration showing the strongest correlation ( r = 0.55, P < 0.001 and r = 0.48, P < 0.001, respectively).

White OC mortality also followed an inverted V pattern, with an increasing trend immediately followed by a decreasing trend (AAPC = −1.26%, 95% CI: 0.51 to 2.01, and P = .001) (Fig. 5 B).

The model suggested an increasing trend in sCr levels during pregnancy in cases who later developed preeclampsia ( p < 0.001; Supplementary Fig. 1).

Figure 2 displays the Kaplan-Meier curves of cumulative incidence of diabetes according to quintiles of the ALT/HDL-C ratio, showing an increasing trend in cumulative incidence of diabetes with increasing quintiles of the ALT/HDL-C ratio (log-rank P < 0.001).

1 A], but not significant in subgroups; proportion of 30-day ART initiation showed an increase trend of 1.0% per month before treat-all (IRR = 1.010, 95% CI : 1.001–1.018; P = 0.030), and after treat-all showed an increasing trend of 0.8% per month (IRR = 1.008, 95% CI : 1.006–1.010; P < 0.001); by the end of 2019 (December 2019), proportion of 30-day ART initiation was not significantly different from the expected level (IRR = 1.044, 95% CI : 0.681–1.600; P = 0.844).

Results There was an increasing trend in Google queries for PRP and shoulder ( R 2 = 0.669, P < .001), elbow ( R 2 = 0.284, P < .001), hip ( R 2 = 0.648, P < .001), knee ( R 2 = 0.802, P < .001), ankle ( R 2 = 0.240, P < .001), and foot ( R 2 = 0.040, P = .009).

Regarding parental and family factors, mothers reported higher parenting stress ( p < 0.001), with an increasing trend over time ( p < 0.001).

The overall prevalence (per 100,000 persons) also showed an increasing trend, from 3065.76 (95% CI: 3051.68–3079.88) to 6296.38 (95% CI: 6277.02–6315.78), with an AAPC of 6.69% (95% CI: 6.45–7.03; p < 0.001) ( Fig. 1 a, Table 3 , Supplementary Table S2 ).

MDR-TB showed a decreasing trend (Z = −3.31, p < 0.01) while resistance to any first-line drugs showed an increasing trend (Z = 5.22, p < 0.001), from 1999 to 2013.

In contrast, the average menstrual cycle length exhibited an increasing trend ( P < 0.001, P -trend < 0.001), while both the average number of menstrual periods per year and the number of ovulatory cycles showed significant decreasing trends ( P < 0.005, P -trend < 0.005), with the Q4 group being significantly lower than the Q1 and Q2 groups.

There was an increasing trend for total treatment expenses from lower to higher RACHS categories (p < 0.001).

In a subanalysis of our postmatch data, we graphed the mortality stratified by age in patients with ICPM and without ICPM which showed an increasing trend of mortality with increasing age in each group (p<0.001) ( figure 2 ).

An increasing trend in all three types of obesity was observed with increasing education status ( P <0.001).

Brazil showed an increasing trend from 2017 to 2019 (annual percentage change [APC]: 0.98, p<0.001) and a stable trend from 2020 to 2022 (APC: 0.42, p<0.080).

There was an increasing trend in the prevalence of CKD with increasing age in all periodontal disease patients ( P <0.001).

In particular, an increasing trend in Lempel-Ziv complexity from REST to FAM and to OMM can be observed [ t (9) = −5.40, p = 0.001; t (9) = −14.46, p < 0.001; t (9) = −9.46, p < 0.001].

The RTI prevalence showed an increasing trend with the decrease in socioeconomic class where 82% of women belonging to the class V or lower socioeconomic group had RTI ( P <0.001) [ Table 4 ].

The results of the present study revealed an increasing trend in juniper growth with decreasing sea ice extent ( r = −0.59, 1901–2015, p < 0.001), particularly during notable recurrent periods of significant ice cover increases in 1907, 1935–1936, 1983–1984 and 2008, resulting in low growth.