“a suggestive trend”

Although the ANOVA comparing NfL changes among ATN groups revealed only a suggestive trend towards significance (likely due to the limited sample size), post hoc analysis demonstrated that the rate of increase was more pronounced in patients with ATN+ status compared to those with isolated A+.

For DEHP metabolites, there was a suggestive trend of increasing isoprostane levels with higher metabolite concentrations, but the associations did not reach statistical significance when metabolites were considered individually.

Baseline apathy showed a suggestive trend with incident MCI, which in our sensitivity analyses was explained by the twofold increased risk of developing nonamnestic MCI.

We found significant LOAD risk association for the minor allele of rs156697 in older subjects and a suggestive trend for delayed age-at-diagnosis.

Despite a suggestive trend of the ACLR–ALLR group toward a higher complication rate (OR = 1.56), the incidence of screw malposition, infection, pain, or arthrofibrosis was statistically comparable between ACLR and ACLR–ALLR procedures.

For Mo groups, there was a statistically significant trend for increased odds of below-reference sperm concentration and a suggestive trend for increased odds of below-reference sperm morphology.

However, arguing against such an association was our failure to detect, among patients with an ST131 or H 30R isolate, even a suggestive trend toward more severe disease or a greater likelihood of infection-associated clinical manifestations or persistence/recurrence.

No association between TSH levels and TgAbs was seen despite a suggestive trend ( Fig. 3 ).

ll association.[ 37 ] There also has been no consistent association between AS or diet beverages and pancreatic cancer after adjusting for relevant confounders, including sugar-sweetened beverages and obesity, which is confirmed by our meta-analysis; although, one case-control study did demonstrate a suggestive trend for AS and reduced odds of pancreatic cancer (adjusted OR 0.62, 95% CI: 0.37–1.04), which was significant for individuals at least 60 years old and also among those with caloric intakes ≥2100 calories/day (study-specific caloric intake threshold per Bosetti et al. ).[ 21 ] Notably, long-term consumption of sugar-sweetened but not artificially sweetened beverages has been associated with increased risk of cancer-related mortality.[ 60 ] While we excluded analyses of cancer-related mortality, no study in our search analyzed GI cancer-related mortality specifically.

The overall survival curves would thus no longer be considered statistically significantly different, although there would remain a suggestive trend.

89 Metabolomic profiling only revealed a suggestive trend of fecal L-Fucose in Atg16l1 ∆IEC mice at trimester 3, which may warrant further investigation due to the important role of fucosylation as a post-translational protein modification in Crohn’s disease and colorectal cancer. 26 , 90–92 We found consistent evidence for an increase in chitin-degradation in Atg16l1 ∆IEC pregnant mice in trimester 3 (day 18 after timed mating), both by higher abundance of the pathway in metagenomic data, as well as increased levels of its metabolite N-acetylglucosamine in the feces of these mice.

In our analyses, we found a suggestive trend for weaker TL–mortality risk associations in reptiles compared to birds that may have been driven by a single outlying study.

Given the sample size, we interpret this as a suggestive trend rather than a definitive association.

Our findings of a suggestive trend towards increased 2.5-year progression of MAC with exposure to outdoor PM 2.5 , if confirmed in additional well-powered studies with longer periods of follow-up, may provide insight into other potential underlying mechanisms linking air pollution to CVD morbidity and mortality.

Therefore, it should be interpreted as a suggestive trend rather than evidence of a protective effect.

In the exploratory cross-breed comparison, Hulunbeier sheep showed a suggestive trend toward enhanced expression of energy metabolism genes (ATP5MC2, ATP5PO, UQCRH) and genes encoding mitochondrial respiratory chain components relative to lowland Hu sheep.

Results showed associations of RA with the use of five specific pesticides reported at AHS enrollment, including 3 insecticides (toxaphene, fonofos, and carbary) and 2 herbicides (atrazine, and chlorimuron ethyl) with notable findings for two pesticides with widespread use, including a significant trend for increasing cumulative days mixing or applying atrazine, an agricultural herbicide, and a suggestive trend for carbaryl, an insecticide with residential and agricultural applications.

Then, the miRNAs that were either previously validated or showed a suggestive trend were quantified by RT‐PCR in an independent cohort.

The atypical neurotherapeutic chosen for strategic optimization, CANTOR (CM 30038; minaprine), showed low risk for cardiotoxicity, drowsiness, or weight gain in neurology patients plus a suggestive trend in AD patient cognitive improvement.

While this study showed no clear evidence for an improvement in pregnancy rates, a suggestive trend encourages us to consider a definitive study with livebirth productivity rate as the appropriate measure.

When the duration of aspirin use was divided into two subgroups (<5 years and ≥5 years), we observed a suggestive trend of decreasing risk of gastric cancer associated with increasing duration of aspirin use (RR = 0.95, 95% CI 0.76–1.14, for <5 years; RR = .67, 95% CI 0.56–0.79, for ≥5 years; Figure S2 ).

Results Among girls, we observed a suggestive trend of increased odds of breast and pubic hair development with higher Alu and LINE-1 methylation in 9-year-old blood, respectively.

There was a suggestive trend of having more enucleation or evisceration in eyes that had bacterial endogenous endophthalmitis (6 eyes, 37.5%) compared with fungal endogenous endophthalmitis (0 eye, 0%) but the difference failed to reach the level of statistical significance (chi-square test, P = 0.07).

In the present study, we also observed a suggestive trend for the IGF1R 3174 A allele to be associated with DWMI.

Sensitivity analysis for the degree of relatedness to rearing individuals indicated that in comparison to twins reared together, only those who were adopted to non-relatives had significantly higher levels of frailty, although there was a suggestive trend towards increasing frailty with increasing degree of relatedness.