“a strong trend”

The pathways analysis outcome between 10 weeks and 6 weeks old 5xFAD mice showed a clear upregulation of immune system related pathways such as interferon-gamma signalling pathways and a strong trend for altered B and T cell activation pathways and interleukin pathways in the 10 weeks old 5xFAD mice (p = 0.055, p = 0.071, respectively) which goes along with the alteration of cytokines we detected in 10-week old 5xFAD brains.

RT-qPCR confirmed significant reduction of FC-induced RNA increase in Top3β-KO mice for Arc, Egr1 , and Npas4 ( p < 0.05); and a strong trend of reduction for c-fos ( p = 0.055) (Supplementary Fig. 6a-d ).

A priori planned comparisons using one-tailed paired t-tests revealed significantly higher scores for dilemmas with humanized than neutral persons on the H scale (H umanized : M = 60.7, SE = 2,5, N eutral : M = 56.2, SE = 2.5, T(53) = 2.36, p = 0.011), a strong trend towards higher scores on the PD scale for dilemmas with H umanized persons (H umanized : M = 59.5, SE = 3.3, N eutral : M = 56.0, SE = 2.6, T(53) = 1.63, p = 0.055), and a weaker trend towards higher scores on the EC scale (H umanized : M = 56.4, SE = 2,5, N eutral : M = 53.8, SE = 2.5, T(53) = 1.30, p = 0.099).

INF-2 data set, the effect of CCL3L CN remained significant ( P =0.01; OR=0.38) and although CCL3 Hap-A1 lost significance upon adjustment for the effect of CCL3L CN, it maintained a strong trend ( P =0.055; OR=0.42).

While this was highly statistically significant compared to preoperative values in terms of Swing Speed, Print Area at WPO2 showed also a strong trend with p = .055.

Interestingly, whilst Aβ 1-40 remains predominant in the slice tissue, the Aβ 1-42 :Aβ 1-40 ratio is significantly higher in slice tissue when compared to the culture medium ( p < 0.0001), with a strong trend for this difference to increase with the age of the slice (p = 0.055) .

The Variable group showed a strong trend toward a positive correlation ( r = 0.37, p = 0.055), but there was no correlation in the Constant group ( r = –0.23, p = 0.24).

However, there was a strong trend toward greater likelihood of TP53 alterations in nonresponders (Fisher’s exact test P = 0.055).

Following repeated defeats, no significant differences in avoidance behavior between treatment groups were observed; however, there was a strong trend for hamsters treated with the low dose of the probiotic to spend significantly more time avoiding a caged opponent compared to placebo-treated hamsters ( p = 0.055) (Fig. 1 b).

Post-hoc tests also showed a strong trend for adaptation to matching stimuli to produce different effects on response as a function of IOCD than adaptation to conflict ( t (15) = 2.1, p = 0.055, Cohen’s d = –0.52).

There were no significant differences in the expression of p-eNOS ( p = 0.41) or total eNOS ( p = 0.15), though there was a strong trend towards a decreased p-eNOS to eNOS ratio ( p = 0.055) in the HYP group compared to NOR.

Although no individual DRN subregion showed a significant effect of social treatment, there was a strong trend in the DRD (Least Significant Difference post hoc test, p = 0.055), but not for other regions ( p > 0.2 for the DRL, DRV, and PDR).

A similar picture was noted in the case of CD8 + T cell reactivity ( Figures 7 C and 7D), where the CD8-E MP recapitulated the reactivity observed with the MPs of larger numbers of predicted peptides (CD8-A+B), with a strong trend (p = 0.0551 by Mann-Whitney) toward more reactivity than the EC class II pool.

In the SOURCE XT registry [ 72 ], the presence of CAD at baseline was associated with a strong trend towards higher 1-year mortality after Edwards SAPIEN XT valve implantation, (HR 1.22; 95% CI (1.00–1.49), p = 0.0552).

Similarly, RNAscope showed a strong trend for an increase in SPP1 in microglia in the CA1 ( P = 0.0553) and molecular layers ( P = 0.0537) of the hippocampus, and a numeric but non‐significant increase in C1qa gene expression in all three hippocampal regions measured (Figure S25D‐J ).

Conversely, in bilateral IPC, a strong trend towards a positive correlation between activity and hit rate was evident in e4+ (p = 0.0559); this was not present in e4- (-ve correlation, p = 0.563).

ANCOVA analysis assessed with body mass showed that the 12 hours of average energy expenditure in the first dark cycle elicited a strong trend ( P = 0.056) of restoration by DCA during sepsis ( Figure 6I ).

Survival analysis (Mantle-Cox test) showed that protection by oral ivermectin gave a strong trend ( P = 0.056, P (trend) = 0.006).

The ATP-linked OCR for healthy pregnancy was significantly decreased compared with the preeclamptic pregnancy ( P <0.01) group; there was a strong trend toward a decrease ( P =0.056) compared with the non-pregnant group ( Figure 2 B).

When we combined subjects with acute DILI from the US DILIN cohort and those with ALF due to drugs other than Apap, to AIH, or to acute hepatitis B [which groups are biologically and patho-physiologically more similar to the acute DILIN subjects], we found a total of three analytes that were significantly different between those who died vs those who lived, namely, serum albumin, IL-6 and IL-8, and one analyte that showed a strong trend towards significance, namely, RANTES (p = 0.056).

This difference was significant for BA.5 (p = 0.032), BN.1 (p = 0.0079), BQ.1 (p = 0.032), BQ1.1 (p = 0.016), XBB.1(P=0.032), and a strong trend for WT (p = 0.056), BA.1 (p = 0.056), and BF.7 (p=0.056).

The only effect of alcohol was a strong trend of reduced accuracy for Incong trials under S‐Stroop, 85.5% (alcohol) versus 89.5% (placebo), F (1, 14) = 4.33, p = 0.056.

We observed a strong trend toward a more advanced disease at diagnosis among patients with detectable CH by MSKCC-IMPACT ( Cerami et al., 2012 ; Gao et al., 2013 ; Fig. 1 A , P = 0.056, one-sided Fisher’s exact test comparing patients with local [stages 0, 1, and 2] and advanced [stages 3 and 4] disease, and Table 1 ).

In beta band a significant relationship was found between BCmax and RT changes (r(48) = − 0.34, p = 0.017), whereas in alpha band, a strong trend to significance was found between FC and RT changes (r(48) = 0.28, p = 0.056) (Fig. 2 ).

CL significantly increased O2 consumption in all stimulated states (T, p < 0.020, all ), and there was a strong trend detected in the basal state (T, p = 0.056, trend ).