However, like Myc high -only tumors, and quite unlike Myc low -only tumors, Myc high /Myc low chimeric tumors were invasive, angiogenic, and predominantly normoxic, exhibiting little necrosis and displaying a strong trend toward increased cellularity ( P = 0.054) ( Fig. 2 C – F and SI Appendix , Fig.
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However, pyruvate and butyrate showed a strong trend for reduced SRC (ANOVA p = 0.054, 0.082 respectively), less so for succinate (0.134) as the data were variable.
After adjusting the Cox proportionate hazards model for age, sex, insulin‐dependent diabetes, hypertension, renal impairment, chronic obstructive lung disease, and congestive heart failure, a strong trend for lower long‐term survival of patients with a higher IFT score was demonstrated (adjusted hazard ratio: 0.6; 95% CI: 0.4‐1.0; P = 0.054; Figure 2 ). 4.
When adjusted for CCS and age at V1, years between first and final CCS measurement, years of education and medication, there was a strong trend for a difference between adropin tertiles ( F 2,446 = 2.931, P = 0.054; estimated marginal mean ± SE of ∆CCS for 1st, 2nd, and 3rd adropin tertiles, − 0.298 ± 0.059, − 0.253 ± 0.057, and − 0.104 ± 0.059, P = 0.065 between 1st and 3rd adropin tertiles).
This effect of HFD was found in the medial ARC ( F (1,27) = 4.55, p = 0.043 x ), and a strong trend was found in the medial VMH ( F (1,25) = 4.29, p = 0.054 y ).
ECOG 0–1 was positively correlated with survival on univariate analysis (p < 0.001); age ≤59 years showed a strong trend ( p = 0.054).
In the WIV vaccination group, depletion of CD4 or CD8 T cell did not significantly alter the weight loss compared with mock depletion but a strong trend toward less weight loss was observed in mice depleted for CD4 T cells as compared to non-depleted mice of this group ( P = 0.054, Figure 6A , WIV).
Interestingly, in females, a 2-way ANOVA revealed a main effect of exposure ( Figure 2B : F (1, 16) = 8.198, p < 0.05) and an exposure × week interaction ( F (2, 32) = 5.07, p < 0.05), with a strong trend toward a main effect of week ( F (2, 32) = 3.208, p = 0.054).
Importantly, a significant increase in the activation of CD4 + T cells was found in the aortic root ( Figure 5f, p = 0.03) and a strong trend towards increased activation was similarly observed in the aorta ( Figure 5k, p = 0.054).
In multivariate analysis, high tumour CIN% was not an independent predictor for RFS (HR: 1.28, 95% CI: 0.74–2.209) but for OS there was a strong trend that did not reach statistical significance (HR: 1.76, 95% CI: 0.99–3.13, P =0.054).
Expression of several SASP markers showed a positive correlation to p16 INK4a levels despite no correlation to age: insulin‐like growth factor binding protein 3 ( IGFBP3 , r 2 = .0971, p = .018), matrix metalloproteinase 1 ( MMP‐1 , r 2 = .1247, p < .01), and a strong trend for MMP‐13 ( r 2 = .0667, p = .054).
The number of 4HNE-positive cells, indicative of oxidative injury, was significantly higher in High V T lambs within the periventricular white matter compared to UVC (p<0.001) and showed a strong trend to be greater than Prot V T lambs (p = 0.054).
This continued until day 34 as a strong trend ( P = 0.0542) towards an increased body weight in birds fed HTM compared to birds fed STM.
Capillary branchpoints improved 1.50-fold, and tip cell formation showed a strong trend toward recovery (10.13-fold, p = 0.0542) (Fig. 6f and Supplementary Fig. 13a, b ).
The Stimulation Group shows a strong trend toward a slower increase in AF burden over time compared with the Sham Group ( P = .0545 for group and time interaction) when time is modeled linearly as a continuous variable in the mixed model.
The pelabresib plus ruxolitinib arm also had a strong trend toward improved TSS50 at 24 weeks ( P = .0545), which was evident across all TSS domains.
Significant deeper crypts were measured in birds fed SH and Li1 (192.93 and 189.22 μm) as well a strong trend towards deeper crypts with Li2 (177.99 μm; p = 0.0547).
Following cocaine exposure, D1R-MSNs were significantly different from their untreated counterparts at select current injections (2-way repeated measures ANOVA, F 8,224 = 3.635, p = 0.0005), and there was a strong trend towards a main effect (2-way repeated measures ANOVA, F 1,28 = 4.021, p = 0.0547); significant differences were observed at 120–180 pA injections (Fig. 4 C, E).
Cell density assessed by DAPI nuclear staining showed a strong trend towards a higher cell density in Ki67 high BM ( p = 0.0548, Fig. 4 , Table 1 ).
Male mice from Poly IC injected mothers showed a strong trend towards normal behavior ( Fig. 3B ; t (6) = 2.38, p = 0.0548).
This motif was found in 50% and 0% of cases with STAT3 ‐mutated and ‐non‐mutated PRCA, respectively, suggesting a strong trend towards enrichment in STAT3 ‐mutated PRCA ( p = 0.0549) (Figure 4D,E ).
For total movement time, there was a main effect of housing (Figure 2b , F(1,29) = 14.89, p = 0.0006), a strong trend towards a main effect of PLX3397 treatment (Figure 2b , F(1,29) = 4.000, p = 0.0549), and an interaction between factors (Figure 2b , F(1,29) = 3.946, p = 0.0565).
Remarkably, there was a strong trend for accelerated tumor growth rates in the HFD-chow FMT mice ( Figure 1 E,F, AUC for tumor growth rate p = 0.0549).
Also, we observed a strong trend toward smaller current density compared with WT Na V 1.2N for Na V 1.2N-S1336Y (−113.7 ± 26.9 pA/pF, n = 10, P = 0.0549).
At this time, there was an overall effect of Drug (F 2,48 = 5.724, p < 0.001) with a strong trend for an Age effect (F 1,48 = 3.876, p = 0.055) and Age × Drug interaction (F 2,48 = 3.171, p = 0.051).