11 Murray et al 11 demonstrated significantly less osteoarthritis in the porcine knee randomized to ACL repair with a bioactive scaffold compared with nonoperative healing and a strong trend toward less arthritis when compared with ACLR at 12 months.
32 , 33 A strong trend toward increased OS was also noted in melanoma BMs with high expression of PD-L1. 34 However, this correlation between PD-L1 expression and treatment response was not seen in a phase 2 trial of atezolizumab (a PD-L1 inhibitor) with carboplatin and pemetrexed in a cohort of patients with nonsquamous NSCLC with untreated BM, 35 suggesting it may not be universally applicable.
Statistical analysis revealed a strong trend for CRPC within the latter group ( Table 2 , upper panel).
In association with changing fertility, there is the longer life expectancy and lower death rates that translate into a strong trend of ageing of the world’s population.
Likewise, the high variability prevented to show a significant difference between IL-1 β and -6 mRNA levels assessed in patients at time 0 and after FU, although a strong trend to a reduction was observed ( Fig. 4 and 5 ).
While both sexes experienced improved analgesic effects during opiate use for pain relief, a KD was only efficacious in reducing opiate consumption in male mice, whereas the females exhibited a strong trend in reduction.
Even though 12 months old BDNF +/− -mice did not perform significantly worse than their wildtype littermates, our data still show a strong trend to an impaired learning performance in these animals at this age.
There was a strong trend for an increase in CD4 + thymocytes in the SLE mice that received the leptin antagonist ( Figure 4 G), so it may be that positive selection of DP thymocytes into a CD4 + or CD8 + thymocytes is impacted in some way.
Clec4e deletion in mice was associated with significantly less acute ischemic cardiac injury, reduced early neutrophil infiltration, and a strong trend toward smaller infarct size at 24 hours’ post–I/R injury.
The current no-mutation and EGFR cohorts had a strong trend to longer OS than the respective historic cohorts.
The mean scores for all individual questions consistently exceeded 4.5, which resulted in a strong trend of “strongly agree” responses among the participants.
We found a strong trend towards evidence of active macrophage infiltration in DCM.
Interestingly, in wild type mice, a volcano plot of the female/male ratio for peptide acetylation revealed a strong trend for higher lysine acetylation in females for nearly all the 2452 measured peptides ( Figure 1 c), with an average log2 fold increase of 4.2.
Whilst there was also a strong trend for better glycaemic control in the carvedilol group compared to the bisoprolol group, this did not quite reach statistical significance.
Multiple factorial analysis has suggested a strong trend towards a decrease in the incidence of AD with an increase in latitude ( Table 3 ), demonstrating dual roles of geography and economy.
While no significant associations of patient survival with AKR1B10 expression were observed, it is noteworthy that in the solid tumors where AKR1B10 is most highly over-expressed, namely liver cancer and squamous cell lung carcinoma, there is a strong trend for AKR1B10 over-expression predicting longer patient survival (Figure 3 C).
Additionally, Atf6 -/- mice showed a significant increase in LVID in diastole compared to Atf6b -/- mice and a strong trend towards increased LVID in diastole compared to Wt mice ( Fig 2 and Table 2 ).
The medical relevance was further supported by the fact that in contrast to placebo, remibrutinib showed a strong trend to increase the salivary flow rate, thereby modifying reduced salivary flow which is a cardinal symptom of SjS with important consequences for oral health. 25 26 This increase of the unstimulated flow was small in absolute terms, which may be due to the long average disease duration of patients in the study who may already have significantly destroyed salivary tissue which can no longer be regenerated.
In the VTA, SCH23390 administration induced a strong trend toward a reduction in c-Fos expression that did not reach statistical significance (R vs.
The lower overall survival probability of patients with low miR-9-2 expression revealed by Kaplan–Meier analysis suggests a strong trend towards prognostic significance ( Figure 6C ).
IFN-α as a monotherapy has fallen out of favor, as a phase III multinational trial between sunitinib and IFN-α demonstrated a strong trend toward a median overall survival advantage of sunitinib over IFN-α [ 33 ].
Even though there were more patients with three or more organ systems (including renal failure) failing in the glutamine group than in the control group [ 97 ], a strong trend toward increased mortality with glutamine remained after adjustment for this imbalance [ 98 , 99 ].
Oppositely, from April to December there is a strong trend towards decreased suitability, consistently reaching values of up to 100% from September to November.
The theoretical remaining sorption capacity (Table 2 ) did not follow a strong trend with hydrophobicity or actual sorbed mass in soil, implying that sorption is not simply explained by SOM content or compound hydrophobicity.
In Kaplan–Meier curve analysis, TACE patients with initial suPAR levels >5.94 ng/mL showed a strong trend toward an impaired OS, but statistical significance was not reached ( P = 0.086, Fig. 3a ).